Ebixa (20mg) 28 Tablets

Memantine, a 20mg tablet, primarily acts as an N-methyl-D-aspartate (NMDA) receptor antagonist. Its mechanism of action involves binding to and modulating the NMDA receptors in the brain, which are crucial for synaptic plasticity and neuronal communication. By blocking the excessive activation of NMDA receptors, memantine helps regulate the abnormal glutamate signaling associated with neurodegenerative diseases. This modulation of glutamate activity is thought to contribute to the therapeutic effects observed in conditions like Alzheimer's disease. Memantine's action aims to improve cognitive function and slow down the progression of symptoms by restoring a balance in neurotransmission and reducing excitotoxicity, which is the damage caused by overstimulation of neurons.

NMDA receptor antagonist.

Tablet

The following are the uses of Memantine 20mg Tablet:

• Used for treating moderate to severe dementia related to Alzheimer's disease.
• Used to improve memory, awareness, and the ability to perform daily functions.
• Used to regulate glutamate, an essential brain chemical for learning and memory.
• Used to delay the worsening of Alzheimer's symptoms, improving quality of life.
• Used to enhance cognitive function and slow cognitive decline.
• Used for patients with moderate to severe Alzheimer's who are unable to take other medications.
• Used as part of a comprehensive treatment plan, often combined with supportive care.
• Used under medical supervision, with regular monitoring to ensure effectiveness and manage side effects.

To be taken as per doctor's prescription

In the case of an overdose of Memantine 20mg Tablets, it is important to recognize the potential symptoms and take appropriate action. An overdose may lead to an increase in the severity of side effects, such as confusion, dizziness, and even hallucinations. If a person has taken an excessive amount of the medication, it is crucial to seek medical assistance promptly. Contact a healthcare professional or emergency services, who can provide guidance on the necessary steps to address the situation effectively.

In the case of a missed dose of Memantine 20mg Tablet, it is important to take the dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss several doses, contact your healthcare provider for advice on how to safely resume your medication and maintain its effectiveness. It is generally recommended to take the missed dose within a few hours of the scheduled time for optimal results.

To take Memantine 20mg Tablet, swallow the tablet whole with a glass of water, preferably with or after a meal, once a day as directed by your healthcare professional; do not crush, chew, or break the tablet, as it is designed to be taken orally and should not be modified.

Here are the conditions or situations when Memantine 20mg Tablet should not be used:

• Avoid using this medication if you are allergic to Memantine or any other similar medications.
• Not recommended for individuals with severe kidney disease or kidney failure.
• Should not be given to patients with severe liver impairment.
• Contraindicated in patients with a history of seizures or epilepsy.
• Do not use this medication to treat dementia caused by conditions other than Alzheimer's disease.
• Not suitable for children and adolescents under 18 years of age.
• Avoid if you have a history of recent heart attack or unstable heart conditions.

The side effects of Memantine 20mg Tablet may include:

• Dizziness
• Headache
• Confusion
• Constipation
• Nausea and vomiting
• Loss of appetite
• Increased agitation or anxiety
• Sleep disturbances

Following are the precautions and warnings for Memantine 20mg Tablet:

• Patients with severe renal impairment or undergoing hemodialysis should not take this medication without consulting a healthcare professional, as dosage adjustments may be necessary.
• It should be used with caution in individuals with a history of seizures, as it may increase the risk of seizures.
• Patients with a history of urinary tract infections or urinary incontinence should exercise caution, as these conditions may worsen.
• Memantine may cause dizziness or drowsiness, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Patients with a history of hypertension should have their blood pressure monitored regularly during treatment.
• This medication should be used with caution in individuals with a history of psychiatric disorders, as behavioral changes may occur.
• Pregnant and breastfeeding women should consult their doctor before taking Memantine, as the risks and benefits should be carefully evaluated.

Following are the drug interactions for Memantine 20mg Tablet:

• Memantine may interact with amantadine, ketamine, and dextromethorphan, leading to increased side effects and toxicity.
• It can decrease the effectiveness of quinolone antibiotics like ciprofloxacin and levofloxacin.
• Anticonvulsants such as phenytoin, carbamazepine, and valproic acid may have reduced efficacy when used with Memantine.
• Memantine can enhance the effects of sedatives and hypnotics, including benzodiazepines and opioids, potentially causing excessive drowsiness.
• Drugs that increase urine pH (e.g., sodium bicarbonate) may decrease the elimination of Memantine, increasing its levels in the body.
• NMDA receptor antagonists like ketamine or dextromethorphan can have additive effects when combined with Memantine.
• Memantine may reduce the effectiveness of anticholinergic medications used in treating gastrointestinal disorders.

Following are the food interactions for Memantine 20mg Tablet:

• Avoid consuming alcohol as it may impair your thinking or reactions, and could worsen side effects like dizziness and confusion.
• Grapefruit and grapefruit juice should be consumed with caution as they can increase the blood levels of Memantine, potentially leading to increased side effects.
• Avoid taking herbal products like St. John's Wort, as it may affect the metabolism of Memantine.
• Do not consume foods high in tyramine (aged cheeses, cured meats, fermented foods) as Memantine may interact with these, causing a potential increase in blood pressure.
• Caffeine intake should be monitored as it can enhance the stimulating side effects of Memantine, leading to restlessness and insomnia.
• There's no need to take Memantine with food, but it can be taken with a glass of water to aid in swallowing the tablet.
• Maintain a consistent level of hydration while on Memantine therapy to avoid potential side effects related to dehydration.

Memantine 20mg Tablets should be stored in a secure and dry location, preferably at room temperature, away from excessive heat, direct sunlight, and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. It is crucial not to store them in the bathroom or kitchen, as these areas may expose the medication to humidity and temperature fluctuations. Always check the expiration date, and if the tablets are no longer needed or have expired, proper disposal is essential. Avoid flushing them down the toilet or sink; instead, consult a pharmacist or healthcare professional for guidance on safe disposal methods. Keep the medication away from children to prevent accidental consumption, ensuring the safety of your household.

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Following are the quick tips for Memantine 20mg Tablet:

• Ensure you have a proper diagnosis for the prescribed condition before starting this medication.
• Take the tablet as directed by your doctor, typically twice daily.
• Swallow the tablet whole with a glass of water; do not crush or chew it.
• Maintain a consistent daily routine for taking the medication.
• Do not stop taking the tablet suddenly without consulting your doctor.
• Inform your doctor about all medications you are currently taking to avoid potential interactions.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.