Eczemus (0.1%) 10g Skin Ointment

Tacrolimus ointment, when applied topically, primarily exerts its therapeutic effects by inhibiting calcineurin, a crucial enzyme in the immune system. This mechanism is selective, targeting activated T cells. Upon inhibition, the production of interleukin-2, a significant cytokine, is reduced, leading to a decrease in T-cell proliferation and subsequent immune response suppression. This localized immunosuppression helps manage skin conditions by reducing inflammation and the overactive immune response associated with these disorders.

Immunosuppressant ointment.

Ointment

The following are the uses of Tacrolimus Ointment:

• Used for treating moderate to severe atopic dermatitis (eczema) in adults and children over 2 years old.
• Used for reducing inflammation and suppressing the immune response in the skin.
• Used for relieving itching and improving skin texture and appearance.
• Used for managing skin conditions when other treatments have been ineffective.
• Used for preventing flare-ups and maintaining control of symptoms.
• Used for short-term and intermittent treatment, not as a long-term solution.
• Used for adjunct therapy with other treatments for optimal results.

In the case of an overdose of Tacrolimus Ointment, it is important to remain calm and take appropriate actions. Contact a healthcare professional or a poison control center immediately for guidance. They will provide specific instructions based on the severity of the overdose. Prompt medical assessment is crucial to determine the necessary treatment, which may include supportive care and management of symptoms. Quick action can help mitigate potential adverse effects and ensure the best possible outcome.

In the case of a missed dose of Tacrolimus Ointment, it is important to apply the medication as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra ointment to make up for the missed dose, as this may increase the risk of side effects. If you miss multiple doses or are unsure about how to proceed, contact your healthcare provider for guidance on managing your medication schedule effectively. They can provide specific instructions tailored to your treatment plan.

To use Tacrolimus Ointment, clean and dry the affected skin area, then apply a thin layer of the ointment to the skin as directed by your healthcare provider, typically twice a day, or as instructed, gently rubbing it in until it is evenly distributed.

Following are the conditions/situations when Tacrolimus Ointment should not be used:

• Must not be used on skin areas with viral infections such as herpes, chickenpox, or shingles.
• Contraindicated in individuals with a known allergy or sensitivity to Tacrolimus or any of the excipients in the ointment.
• Not recommended for use on skin areas with bacterial or fungal infections; proper treatment for the infection should be administered first.
• Avoid using on skin with perioral dermatitis or any other inflammatory skin conditions without a doctor's advice.
• Do not use on skin that is broken, severely damaged, or has open wounds.
• Tacrolimus Ointment is not to be used near the eyes or on eyelids due to potential eye irritation.
• Should not be applied on skin areas with skin cancer or suspected skin cancer lesions.
• Not suitable for individuals who have a history of skin reactions to sunlight (photosensitivity).

The possible side effects of Tacrolimus Ointment are:

• Burning or itching at the application site
• Skin redness or irritation
• Skin dryness or peeling
• Acne or pimples
• Allergic reactions (skin rash, hives, itching)
• Increased sensitivity to sunlight
• Skin infection (symptoms may include redness, swelling, pain, or oozing)
• Headache

Following are the precautions and warnings for Tacrolimus Ointment:

• Avoid using Tacrolimus Ointment on skin that is sunburned, severely dry, or irritated. Ensure the skin is clean and dry before application.
• This medication should not be used in individuals with a known allergy or sensitivity to Tacrolimus or any of its ingredients.
• Tacrolimus Ointment is for external use only. Do not apply it near the eyes, mouth, or open wounds.
• Caution should be exercised when using Tacrolimus Ointment on the face, as it may cause increased sensitivity to sunlight. Avoid excessive sun exposure and use sunscreen when outdoors.
• Do not cover the treated area with airtight dressings or bandages, as this may increase the absorption of the medication.
• Children and elderly patients should use Tacrolimus Ointment with caution and under medical supervision, as they may be more sensitive to its effects.
• Inform your healthcare provider if you have any skin conditions or are using other topical medications to avoid potential interactions or adverse effects.

Following are the drug interactions for Tacrolimus Ointment:

• Tacrolimus Ointment may interact with other topical immunosuppressive medications, such as corticosteroids, potentially increasing the risk of skin irritation or delayed wound healing.
• Concurrent use with other immunosuppressive drugs (e.g., oral tacrolimus, cyclosporine) can increase the risk of systemic immunosuppression, leading to a higher susceptibility to infections.
• Tacrolimus Ointment may interact with drugs that are metabolized by the CYP3A4 enzyme, as tacrolimus is metabolized by this enzyme. Drugs like ketoconazole, erythromycin, or grapefruit juice may increase tacrolimus levels, increasing the risk of systemic side effects, such as nephrotoxicity or neurotoxicity.
• Use of Tacrolimus Ointment with other medications that increase the risk of infections (e.g., corticosteroids, certain cancer therapies) should be carefully monitored to avoid further suppressing the immune system.
• Caution is advised when using Tacrolimus Ointment with topical medications that contain alcohol, as they may cause skin irritation or enhance the absorption of tacrolimus.
• Tacrolimus Ointment should not be combined with UV light therapy or tanning beds, as these can increase the risk of skin cancers due to immune system suppression.
• Use with other topical products that may cause skin irritation, such as exfoliating agents or alcohol-based solutions, may increase the risk of skin reactions or discomfort.
• When used with other dermatologic treatments (e.g., topical antibiotics, antifungals), the combined effect may increase the risk of skin irritation or dryness.

Following are the food interactions for Tacrolimus Ointment:

• Avoid consuming grapefruit and grapefruit juice as they can interfere with the absorption of Tacrolimus, leading to unpredictable blood levels and potential side effects.
• Alcohol application on the skin is not recommended as it can increase skin sensitivity and irritation, especially when used with Tacrolimus Ointment.
• Dairy products may interact with Tacrolimus, as some studies suggest that calcium-rich foods can reduce the absorption of the drug. Consider spacing out the intake of dairy and Tacrolimus applications.
• Foods rich in potassium, like bananas and oranges, might need monitoring. Tacrolimus can increase potassium levels, and high potassium intake may require adjustments.
• Avoid excessive consumption of salt and processed foods. High sodium intake can affect skin conditions and interact with the efficacy of Tacrolimus.
• Limit caffeine intake as it can impact blood flow to the skin, potentially influencing the absorption and effectiveness of Tacrolimus Ointment.
• Certain vegetables like kale, spinach, and broccoli, which are high in vitamin K, may require attention. Tacrolimus can affect blood clotting, and vitamin K-rich foods might need monitoring.
• Consult your healthcare provider regarding any herbal supplements or alternative medicines, as some may interact with Tacrolimus, affecting its efficacy.

Tacrolimus Ointment should be stored with care to ensure its effectiveness and safety. Keep the ointment in a cool, dry place, preferably at room temperature, away from excessive heat, direct sunlight, and moisture. It is crucial to store it in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. Pay close attention to the expiration date, and avoid using the ointment if it has expired. When it's time to dispose of the ointment, do not flush it down the toilet or pour it into any water source. Instead, follow local guidelines for pharmaceutical waste disposal or consult your pharmacist for appropriate methods to ensure safe and environmentally friendly disposal. Keep the ointment out of children's reach to prevent accidental contact or ingestion.

Following are the quick tips for Tacrolimus Ointment:

• Apply a thin layer as directed by your doctor, typically twice a day, to affected areas.
• Wash your hands before and after application to maintain hygiene.
• Gently clean the affected skin before applying the ointment.
• Use the ointment consistently to achieve the best results, even if symptoms improve.
• Avoid covering the treated area with bandages or tight clothing to allow the skin to breathe.
• Do not use more than the prescribed amount, and follow the treatment duration advised by your doctor.
• Store the ointment at room temperature, away from direct sunlight and moisture.