Efemoline (1/0.25mg) 5ml Eye Suspension

Naphazoline and Phenylephrine are both sympathomimetic amines that primarily act as selective alpha-adrenergic receptor agonists. When administered, these compounds bind to alpha-adrenergic receptors in the blood vessels of the nasal mucosa, leading to vasoconstriction. This mechanism reduces blood flow to the nasal passages, resulting in decreased congestion and inflammation. Naphazoline primarily targets alpha-1 and alpha-2 adrenergic receptors, while Phenylephrine has a higher affinity for alpha-1 receptors. The vasoconstriction effect helps to relieve symptoms of nasal congestion and provides temporary relief from nasal discomfort.

Decongestant

Suspension

The following are the uses of Naphazoline, Phenylephrine 1mg Syrup/Suspension:

• Used for temporarily relieving nasal congestion due to colds, allergies, sinusitis, and other respiratory issues.
• Used for reducing nasal swelling and irritation.
• Used for providing temporary relief from nasal discomfort and stuffiness.
• Used for promoting easier breathing through the nose.
• Used for treating symptoms of non-allergic rhinitis.
• Used for clearing nasal passages before medical procedures or examinations.
• Used for alleviating congestion associated with sinus headaches.
• Used for controlling excessive nasal secretions.

In the case of an overdose of Naphazoline and Phenylephrine 1mg Syrup/Suspension, individuals may experience symptoms such as severe drowsiness, dizziness, rapid heartbeat, high blood pressure, and in extreme cases, loss of consciousness. Immediate medical attention is necessary, and patients should be closely monitored for any signs of respiratory depression, especially in children. Prompt treatment and supportive care can help manage the symptoms and prevent potential complications.

In the case of a missed dose of Naphazoline and Phenylephrine 1mg Syrup/Suspension, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. It's important to adhere to the prescribed frequency of doses, typically every 4-6 hours, and consult your healthcare professional if you have any concerns or if you miss multiple doses.

To administer Naphazoline and Phenylephrine 1mg Syrup/Suspension, shake the bottle well, measure the prescribed dose with an accurate measuring device, and administer it orally, following the dosage instructions provided by your healthcare professional, typically once or twice a day, regardless of meals, and adhering to the recommended dosage for your specific needs.

Here are the conditions or situations when Naphazoline and Phenylephrine 1mg Syrup/Suspension should not be used:

• Avoid using if you have an allergy or sensitivity to Naphazoline, Phenylephrine, or any other similar decongestant medications.
• Not suitable for individuals with narrow-angle glaucoma or those who have recently undergone certain eye surgeries.
• Contraindicated in patients with severe cardiovascular diseases, including uncontrolled high blood pressure, coronary artery disease, and cardiac arrhythmias.
• Should not be used in patients with severe kidney disease or those on dialysis.
• Not recommended for individuals with an overactive thyroid (hyperthyroidism).
• Avoid using if you have a history of urinary retention or difficulty urinating.
• Do not use in patients with diabetes, as it may affect blood sugar control.
• Contraindicated in patients who have taken monoamine oxidase inhibitors (MAOIs) within the last 14 days.
• Not suitable for infants or young children, unless specifically prescribed by a pediatrician.

The side effects of Naphazoline and Phenylephrine 1mg Syrup/Suspension may include:

• Increased heart rate
• High blood pressure (hypertension)
• Nervousness or anxiety
• Dizziness or lightheadedness
• Headache
• Nausea and vomiting
• Dry mouth
• Nasal irritation or dryness

Following are the precautions and warnings for Naphazoline, Phenylephrine 1mg Syrup/Suspension:

• Do not use this medication if you have a known allergy to Naphazoline, Phenylephrine or any other ingredients in the syrup.
• Individuals with high blood pressure, heart disease, diabetes, or thyroid problems should use with caution and under medical supervision.
• Avoid using the syrup if you have narrow-angle glaucoma or urinary retention.
• This medication may cause drowsiness or dizziness, so avoid driving or operating heavy machinery until you know how it affects you.
• Consult a doctor if you have a history of respiratory problems, as this medication may worsen breathing difficulties.
• Pregnant and breastfeeding women should seek medical advice before using this syrup.
• Do not exceed the recommended dosage, as overuse may lead to a rebound effect and worsen symptoms.

Following are the drug interactions for Naphazoline and Phenylephrine 1mg Syrup/Suspension:

• Should not be used with monoamine oxidase inhibitors (MAOIs) due to potential severe hypertension.
• Concomitant use with other alpha-adrenergic agonists or imidazolines may result in increased blood pressure.
• Drugs metabolized by CYP450 enzymes, particularly CYP2D6, may have altered metabolism when used with phenylephrine.
• Can interact with tricyclic antidepressants, increasing cardiovascular effects.
• Beta-blockers may reduce the effectiveness of naphazoline and phenylephrine.
• Sympathomimetic agents like amphetamines or cocaine can enhance cardiovascular effects.
• Antihypertensive medications may have reduced efficacy when combined with this syrup.

Following are the food interactions for Naphazoline and Phenylephrine 1mg Syrup/Suspension:

• Grapefruit and grapefruit juice consumption should be avoided as they may interfere with the breakdown of the medication, leading to increased side effects.
• Alcohol intake should be minimized or avoided as it can cause additional nasal congestion and may also enhance the sedative effects of the medication.
• Spicy foods are best avoided as they can trigger a histamine response, potentially increasing nasal symptoms and reducing the effectiveness of the medication.
• Hot beverages like coffee or tea may cause vasodilation, which could counteract the vasoconstricting effect of the medication.
• Dairy products, especially those high in histamine, might exacerbate nasal congestion and should be consumed in moderation.
• Chocolate contains compounds that can dilate blood vessels, potentially increasing nasal congestion and reducing the medication's efficacy.
• Preserved or processed foods with high sodium content can contribute to fluid retention and may make nasal congestion worse.
• While not a food, smoking should be avoided as it irritates the nasal passages and can reduce the effectiveness of the medication.

Naphazoline and Phenylephrine 1mg Syrup/Suspension should be stored in a secure and controlled environment, preferably in a designated medicine cabinet or storage area. Keep the medication away from direct sunlight, heat, and moisture, as these conditions can degrade the quality of the syrup. Always ensure the bottle is tightly sealed after each use to maintain its integrity. When disposing of the medication, do not pour it down the drain or flush it; instead, follow local guidelines for pharmaceutical waste disposal, which may involve returning it to a pharmacy or a designated collection site. It is crucial to keep this medication out of the reach of children and pets to prevent accidental ingestion, and always consult a healthcare professional or pharmacist for specific instructions on storage and disposal if you have any concerns. Proper handling and disposal are essential to ensure safety and environmental responsibility.

Following are the quick tips for Naphazoline, Phenylephrine 1mg Syrup/Suspension:

• Always follow the prescribed dosage and duration provided by your healthcare professional.
• Shake the bottle well before each use to ensure a consistent mixture.
• Administer the syrup with a measuring cup or oral syringe for accurate dosing.
• Avoid consuming citrus fruits or juices immediately after taking the medication.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Do not freeze the medication as it may affect its effectiveness.
• Dispose of any unused or expired medication safely.