Eflogen (11.5%) 15g Cream

Eflornithine cream works by inhibiting the enzyme ornithine decarboxylase (ODC), which plays a crucial role in the growth and proliferation of hair follicles. When applied topically, eflornithine penetrates the skin and reaches the hair follicles, where it blocks the activity of ODC. This enzyme is responsible for converting ornithine into putrescine, a polyamine that is essential for cell growth and division. By inhibiting ODC, eflornithine disrupts the production of putrescine, which, in turn, slows down the growth of unwanted facial hair. The reduction in putrescine levels leads to a decrease in hair follicle activity and ultimately results in slower hair growth. This mechanism specifically targets the hair follicles without affecting the surrounding skin, making it an effective treatment for unwanted facial hair in women.

Eflornithine

Ornithine decarboxylase inhibitor

Cream

The following are the uses of Eflornithine Cream:

• Used for treating unwanted facial hair in women.
• Used for reducing excessive hair growth caused by hormonal imbalances.
• Used for managing hirsutism, a condition of male-pattern hair growth in women.
• Used for cosmetic purposes to improve skin appearance and texture.
• Used for long-term hair removal when applied consistently over time.
• Used for slowing down hair growth rate, resulting in finer and less noticeable hair.
• Used for providing a non-invasive alternative to laser hair removal or electrolysis.
• Used for helping to boost self-confidence and overall well-being related to unwanted hair concerns.

Follow these dosage instructions:

• Take as per doctor's Prescription.
• Apply the cream on the affected site at least once daily.
• Your doctor will determine the treatment length based on your symptom severity.

In the case of an overdose of Eflornithine Cream, it is important to note that it is typically well-tolerated when applied topically. However, if a large amount is accidentally ingested, symptoms such as nausea, vomiting, or dizziness may occur. Promptly contact a healthcare professional or a poison control center for guidance. They will provide specific instructions for managing the situation, which may include inducing vomiting or administering activated charcoal to prevent further absorption.

In the case of a missed dose of Eflornithine Cream, it is important to apply the cream as soon as you remember. However, if it is almost time for your next scheduled application, skip the missed dose and continue with your regular schedule. Do not apply extra cream to make up for the missed dose. It is generally recommended to apply the cream twice a day, with an interval of at least 8 hours between applications. If you frequently miss doses, it's best to consult your healthcare provider for advice on how to adjust your treatment plan.

To apply Eflornithine Cream, clean and dry the affected area, then apply a thin layer of cream as directed by your healthcare provider, typically twice a day, ensuring you massage it gently into the skin for optimal absorption.

Here are the conditions and situations when Eflornithine Cream should not be used:

• Avoid using this cream if you have an allergic reaction to eflornithine or any other ingredients in the cream.
• Do not use if you have open wounds, cuts, or irritated skin in the area of application.
• Contraindicated for individuals with severe renal (kidney) impairment.
• Not recommended for children under 12 years of age.
• Do not use on skin conditions like eczema, psoriasis, or severe skin inflammation.
• Avoid using Eflornithine Cream if you are pregnant or breastfeeding, as the effects on the baby are not well established.
• Do not use this cream on areas other than the face, as it is specifically approved for unwanted facial hair.
• Not suitable for individuals with a history of hypersensitivity to any topical medications.
• Do not use this cream if you have recently had any facial treatments like chemical peels, laser therapy, or dermabrasion.

The side effects of Eflornithine Cream may include:

• Skin irritation or redness at the application site
• Burning or stinging sensation
• Itching or rash
• Dry skin
• Acne or pimples
• Skin discoloration
• Increased hair growth (hypertrichosis) in rare cases
• Allergic reactions (such as swelling, hives, or difficulty breathing)

Following are the precautions and warnings:

• Eflornithine Cream is for external use only and should be applied only to the affected areas of the skin. Do not ingest or apply to the eyes, mouth, or other mucous membranes.
• Perform a patch test on a small area of skin before using the cream to ensure you don't have an allergic reaction. Discontinue use if redness, itching, or irritation occurs.
• This cream is not recommended for use on open wounds, cuts, or severely inflamed skin.
• Avoid using Eflornithine Cream in combination with other topical medications without consulting a healthcare professional.
• Wash your hands thoroughly before and after applying the cream to avoid accidental contact with sensitive areas.
• Keep out of reach of children and pets. Store at room temperature, away from direct sunlight and heat.
• Consult a doctor if you are pregnant, planning to become pregnant, or breastfeeding, as the effects of Eflornithine Cream during these periods are not well-studied.
• Do not use this cream for conditions other than those prescribed by your healthcare provider, and do not exceed the recommended dosage.

Following are the drug interactions for Eflornithine Cream:

• No known interactions with other topical medications have been reported, but concurrent use with other topical treatments should be done cautiously.
• Eflornithine cream should not be used in combination with other hair removal methods like waxing, as it may increase skin irritation.
• Avoid using it with abrasive or harsh skin care products that may cause skin damage.
• It is advisable to consult a doctor before using any other medications or creams on the face while using eflornithine cream.
• The effectiveness of eflornithine may be reduced when used with products containing sulfur, resorcinol, or salicylic acid.
• Topical retinoids may increase the absorption of eflornithine; use with caution and monitor for increased side effects.
• Limited data suggests that eflornithine cream can be used with oral contraceptives without significant interactions.

Following are the food interactions for Eflornithine Cream:

• Eflornithine cream should be used with caution if you regularly consume foods rich in histamine or tyramine, such as aged cheeses, cured meats, and certain types of fish, as it may affect the breakdown of these substances in the body.
• Avoid consuming excessive amounts of caffeine while using the cream, as it may interact with the medication's effects on the central nervous system.
• There is no direct interaction between Eflornithine and specific food items, but maintaining a healthy and balanced diet is recommended for overall skin health.
• The cream is for external use only, so food interactions are generally not a concern.
• Eflornithine does not significantly interact with the metabolism of most nutrients, so dietary restrictions are not typically necessary.
• Consuming a diet rich in antioxidants and vitamins may support skin health and complement the use of Eflornithine cream.
• Avoid applying the cream immediately after consuming spicy foods, as skin sensitivity may be heightened.

Eflornithine Cream should be stored in a secure and controlled environment, specifically in a cool and dry place at room temperature, ideally between 68°F and 77°F (20°C and 25°C). Protect the cream from exposure to direct sunlight, heat, and moisture to maintain its stability and effectiveness. Always keep the medication in its original container, tightly sealed, to prevent contamination. It is crucial to check the expiration date before each use and discard any expired or unused cream properly. For safe disposal, avoid flushing it down the toilet or pouring it into drainage systems. Instead, consult your pharmacist or healthcare professional for appropriate disposal guidelines in your area. Ensure that the cream is kept out of the reach of children and pets to prevent accidental exposure or ingestion.

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Following are the quick tips for Eflornithine Cream:

• Consult your healthcare professional before using the cream, especially if you have any skin conditions.
• Apply a thin layer to the affected area as directed by your doctor.
• Ensure the cream is completely absorbed before coming into contact with clothing to prevent staining.
• Wash your hands thoroughly after application to avoid accidental contact with eyes or sensitive areas.
• Avoid applying the cream to broken or irritated skin.
• Do not use on skin that is sunburned or exposed to extreme cold or wind.
• Store the cream at room temperature, away from direct sunlight and moisture.