Emglif-M (12.5/1000mg) 14 Tablets

Metformin primarily works by reducing glucose production in the liver through the inhibition of gluconeogenesis and glycogenolysis. It enhances insulin sensitivity, allowing cells to utilize glucose more effectively. On the other hand, Empagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, acts by blocking glucose reabsorption in the proximal tubules of the kidneys. This mechanism increases glucose excretion in urine, thereby lowering blood glucose levels and improving glycemic control. The combined effect of these two drugs provides a synergistic approach to managing blood sugar levels in patients with type 2 diabetes.

SGLT2 inhibitor, Biguanide.

Oral

The following are the uses of Metformin 1000mg, Empagliflozin 12.5mg Tablet:

• Used for managing type 2 diabetes
• Used to control blood sugar levels
• Used to improve insulin sensitivity
• Used to reduce glucose production in the liver
• Used to increase glucose absorption by muscles
• Used to lower the risk of cardiovascular complications
• Used as part of a comprehensive diabetes treatment plan

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• For empagliflozin 12.5mg, the recommended dosage is one tablet once a day.
• For metformin 1000mg, the recommended dosage is two tablets of 500mg once a day.
• The recommended dosage for empagliflozin and metformin is subject to change depending on individual age, gender, and disease severity. Hence, consult a doctor for guidance.

In the case of an overdose of Metformin 1000mg and Empagliflozin 12.5mg tablets, individuals may experience symptoms such as nausea, vomiting, diarrhea, and abdominal pain. The severity of these symptoms can vary depending on the amount ingested. It is important to seek medical advice promptly, as healthcare professionals may recommend specific treatments to manage any adverse effects. Timely intervention can help prevent potential complications and ensure the well-being of the individual.

In the case of a missed dose of Metformin 1000mg, take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. For Empagliflozin 12.5mg, if you miss a dose, take it as soon as you remember, but if it's close to your next dose, skip the missed dose and resume your regular dosing schedule. It is important not to double the dose to compensate for the missed one. Consult your doctor if you frequently miss doses or have concerns about managing your medication.

To take Metformin 1000mg and Empagliflozin 12.5mg tablets, swallow one tablet daily as directed by your healthcare provider, preferably with a meal to enhance absorption, and follow the prescribed dosage instructions provided by your doctor.

Following are the conditions or situations when Metformin 1000mg and Empagliflozin 12.5mg Tablet should not be taken:

• Should not be used in individuals with a known allergy to Metformin, Empagliflozin, or any of the tablet's components.
• Contraindicated in patients with severe kidney disease or those with a history of diabetic ketoacidosis.
• Not suitable for individuals with a history of a serious allergic reaction to any other SGLT2 inhibitor.
• Should not be used if you have a severe infection, severe dehydration, or are experiencing diabetic ketoacidosis.
• Contraindicated during pregnancy and breastfeeding.
• Not recommended for individuals with type 1 diabetes.
• Avoid if you have a scheduled surgery or any procedure with contrast dye.

The side effects of Metformin 1000mg and Empagliflozin 12.5mg Tablet may include:

• Nausea and vomiting
• Diarrhea or stomach pain
• Metallic taste in the mouth
• Increased urination
• Genital yeast infections
• Low blood sugar (hypoglycemia)
• Fatigue and weakness
• Dizziness or lightheadedness

Following are the precautions and warnings for Metformin 1000mg, Empagliflozin 12.5mg Tablet:

• This medication should not be used in patients with a known allergy to Metformin or Empagliflozin or any other ingredients in the tablet.
• Patients with kidney or liver disease should use this medication with caution as it can affect kidney function. Regular monitoring is advised.
• Alcohol consumption should be avoided or limited while taking this medication as it may increase the risk of lactic acidosis.
• Patients with a history of diabetic ketoacidosis should not use this medication, and it should be temporarily discontinued if undergoing any radiologic studies using iodinated contrast materials.
• Elderly patients may be more susceptible to the side effects of this medication, especially kidney-related issues.
• Patients should be aware of the symptoms of lactic acidosis and seek medical attention if experienced.
• This medication may cause dehydration, leading to a drop in blood pressure; caution is advised, especially in hot weather or during exercise.
• Consult a healthcare professional if you have any concerns or pre-existing medical conditions before starting this medication.

Following are the drug interactions for Metformin 1000mg, Empagliflozin 12.5mg Tablet:

• Diuretics, especially those that inhibit the renin-angiotensin-aldosterone system, may increase the risk of hypoglycemia when used with Metformin.
• Empagliflozin may cause volume depletion, so caution is advised when using it with other diuretics or antihypertensive agents.
• Non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the blood pressure-lowering effect of Empagliflozin.
• Drugs that affect kidney function or reduce blood flow to the kidneys may impact Empagliflozin's elimination.
• Insulin or insulin secretagogues may increase the risk of hypoglycemia when used with Metformin.
• Certain contrast agents used in imaging procedures may lead to acute kidney injury when used with Metformin and Empagliflozin.
• Corticosteroids and beta-2 agonists may increase blood glucose levels, reducing the effectiveness of Metformin and Empagliflozin.
• Drugs that affect the gastrointestinal tract, such as proton pump inhibitors, may alter the absorption of Metformin.

Following are the food interactions for Metformin 1000mg and Empagliflozin 12.5mg Tablet:

• Alcohol consumption should be limited as it can increase the risk of lactic acidosis with Metformin, and may also affect blood glucose levels.
• Avoid high-sugar foods and beverages as Empagliflozin can cause increased urination and lead to dehydration.
• Maintain a balanced diet with consistent carbohydrate intake to manage blood sugar levels effectively.
• Grapefruit and grapefruit juice should be avoided as they can affect the metabolism of Empagliflozin, altering its effectiveness.
• Avoid high-potassium foods like bananas, oranges, and tomatoes if you have kidney issues, as Empagliflozin can increase potassium levels.
• Monitor salt and sodium intake, especially with processed foods, as Empagliflozin can lead to low blood pressure and electrolyte imbalances.
• Ensure adequate fluid intake to prevent dehydration, especially during exercise or in hot weather.
• Consult a healthcare professional for personalized dietary advice, especially if you have specific dietary restrictions or preferences.

Metformin 1000mg and Empagliflozin 12.5mg tablets should be stored in a cool, dry place, preferably at room temperature, ensuring protection from light and moisture. The original packaging should be tightly sealed to maintain its integrity and prevent contamination. Avoid storing in bathrooms or near heat sources, as temperature fluctuations can impact the medication's effectiveness. Dispose of any unused or expired tablets responsibly, refraining from flushing them or pouring them down the drain. Consult your pharmacist for guidance on proper disposal methods, and keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Metformin 1000mg, Empagliflozin 12.5mg Tablet:

• Consult your doctor for the right dosage and duration of medication.
• Take the tablet as directed, usually once or twice daily with meals.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Maintain a consistent medication schedule for better control.
• Do not skip doses; if you miss one, take it as soon as you remember, unless it's almost time for the next dose.
• Inform your doctor about all the medications you are taking to avoid potential interactions.
• Regularly monitor your blood sugar levels as advised by your healthcare provider.

When taking Empagliflozin and Metformin HCl, you may not need specific lab tests unless your doctor deems them necessary based on your health condition and symptoms. However, it is essential to undergo regular monitoring and lab tests as prescribed by your doctor to ensure that the medications are effective in managing your blood sugar levels and to detect potential risks or complications. These tests are designed to complement the treatment process and offer insights into critical aspects of your health, such as blood sugar control, kidney function, liver function and potential electrolyte imbalances. By undergoing these tests, you make sure that any necessary adjustments can be made in your treatment plan, ensuring optimal care and management of your diabetes. Lab tests like the Hemoglobin A1c (HbA1c) test help determine average blood sugar levels and assess how well your blood sugar is controlled. Fasting Blood Sugar (FBS) and Postprandial Blood Sugar (PPBS) tests offer insights into how your body processes glucose before and after meals. Kidney function tests like serum creatinine, urine analysis, and protein levels ensure that Metformin is not causing kidney damage. Meanwhile, liver function tests like bilirubin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) help confirm that Metformin is being processed correctly and not causing liver damage. Finally, electrolyte level tests help mitigate the risk of imbalances, which can affect nerve and muscle function in people with diabetes.