Eumovate (0.05%) 100g Ointment

Clobetasone butyrate ointment primarily exerts its therapeutic effects through its potent anti-inflammatory and immunosuppressive properties. When applied topically, clobetasone butyrate binds to intracellular glucocorticoid receptors in various skin cells, including lymphocytes, macrophages, and mast cells. This binding triggers a series of cellular events that result in the suppression of multiple inflammatory pathways. It inhibits the production and release of pro-inflammatory mediators such as cytokines, prostaglandins, and leukotrienes, which are responsible for the signs and symptoms of inflammation. By reducing the activity of these immune cells and inflammatory substances, clobetasone butyrate effectively alleviates itching, redness, and swelling associated with various skin conditions.

Clobetasone Butyrate

Corticosteroid ointment.

Ointment

The following are the uses of Clobetasone Butyrate Ointment:

• Used for treating various skin conditions like eczema, psoriasis, and dermatitis.
• Used for reducing inflammation and itching associated with skin allergies.
• Used for managing skin reactions caused by insect bites or contact with irritants.
• Used for relieving symptoms of skin rashes and hives.
• Used for treating scalp conditions such as seborrheic dermatitis.
• Used for providing relief from redness, swelling, and discomfort in affected areas.
• Used for long-term management of chronic skin disorders under medical supervision.
• Used for preventing flare-ups and maintaining skin health in specific conditions.

In the case of an overdose of Clobetasone Butyrate Ointment, it is important to recognize the signs and take appropriate action. Symptoms may include a burning or itching sensation at the application site, redness, or an exacerbation of existing skin conditions. If ingested, gastrointestinal discomfort, nausea, or vomiting may occur. Promptly seek medical advice if you suspect an overdose, and provide healthcare professionals with details regarding the amount and timing of the application to ensure proper treatment and management.

In the case of a missed dose of Clobetasone Butyrate Ointment, it is important to apply the medication as soon as you remember. If it is almost time for your next dose, skip the missed one and continue with your regular schedule. Do not apply extra ointment to make up for the missed dose, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or asking someone to help you remember to apply the ointment as prescribed. Consult your healthcare provider if you have any concerns or if you miss multiple doses.

To apply Clobetasone Butyrate Ointment, clean and dry the affected skin area, then gently apply a thin layer of the ointment, rubbing it in completely, usually once or twice a day, or as directed by your healthcare provider.

Following are the conditions when Clobetasone Butyrate Ointment should not be applied:

• Must not be used if you are allergic to Clobetasone Butyrate or any other similar corticosteroids.
• Avoid using on skin with bacterial, fungal, or viral skin infections unless directed by a doctor.
• Do not use on skin that is broken or has open wounds.
• Not suitable for children under 12 years of age without medical advice.
• Should not be used to treat acne, rosacea, or perioral dermatitis.
• Avoid applying on skin that is thin, fragile, or lacking elasticity.
• Do not use on skin with a history of sensitivity or adverse reactions to corticosteroids.
• Contraindicated for individuals with certain skin conditions like psoriasis or dermatitis without medical supervision.

The side effects of Clobetasone Butyrate Ointment may include:

• Thinning of the skin
• Stretch marks
• Burning or stinging sensation
• Skin irritation or redness
• Acne at the application site
• Excessive hair growth in the treated area
• Allergic reactions (skin rash, itching, swelling)
• Increased blood pressure (if used for a prolonged period)

Following are the precautions and warnings for Clobetasone Butyrate Ointment:

• Avoid using Clobetasone Butyrate Ointment on the face, especially around the eyes, unless directed by a healthcare professional.
• Prolonged use or application to large areas of the skin should be avoided without medical supervision.
• Do not use this ointment on skin infections or open wounds.
• It is not recommended for children under 12 years of age unless prescribed by a doctor.
• If irritation or allergic reactions occur, discontinue use and consult a healthcare provider.
• Do not use occlusive dressings over the treated area as this may increase the risk of side effects.
• Consult a doctor if the condition does not improve or worsens after a few days of treatment.
• Keep out of reach of children and pets.

Following are the drug interactions for Clobetasone Butyrate Ointment:

• Using other topical corticosteroids or calcineurin inhibitors like tacrolimus or pimecrolimus simultaneously can increase the risk of skin atrophy and other local adverse effects.
• The absorption of Clobetasone Butyrate can be enhanced by occlusive dressings, increasing the risk of systemic side effects.
• Combining with oral corticosteroids may lead to an increased risk of systemic corticosteroid side effects.
• Clobetasone Butyrate may interact with drugs that affect the CYP3A4 enzyme, potentially altering its metabolism.
• It may decrease the effectiveness of live vaccines due to its immunosuppressive properties.
• Anticoagulants such as warfarin may have their effects potentiated, increasing the risk of bleeding.
• Prolonged use with other drugs that suppress the immune system could result in an increased susceptibility to infections.

Following are the food interactions to consider with Clobetasone Butyrate Ointment:

• Avoid consuming excessive amounts of vitamin A-rich foods like liver, fish oils, and certain supplements, as Clobetasone Butyrate can interact with vitamin A, increasing the risk of vitamin A toxicity.
• Limit your intake of foods high in calcium, such as dairy products, as calcium can potentially interact with the absorption of Clobetasone Butyrate.
• Grapefruit and grapefruit juice should be avoided as they may interfere with the metabolism of certain medications and potentially affect the effectiveness of Clobetasone Butyrate.
• Alcohol may not directly interact with Clobetasone Butyrate, but it can worsen skin conditions and impair wound healing, so it's advisable to limit alcohol consumption during treatment.
• Avoid spicy foods, as they may cause skin irritation and exacerbate skin conditions that Clobetasone Butyrate is used to treat.
• While not a direct food interaction, staying well-hydrated is essential when using Clobetasone Butyrate Ointment to support overall skin health.
• Consult your healthcare provider for personalized advice regarding any specific dietary restrictions or recommendations during treatment with Clobetasone Butyrate Ointment.

Clobetasone Butyrate Ointment should be stored in a cool and dry place, preferably at room temperature, ensuring it is not exposed to direct sunlight or extreme heat. Keep the ointment in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. It is crucial not to store it in the bathroom or near any heat-emitting appliances, as temperature fluctuations can impact its effectiveness. Always check the expiry date before application, and dispose of any remaining ointment after the expiration date. When discarding the ointment, do not flush it down the toilet or pour it into any water source; instead, consult your pharmacist or healthcare provider for appropriate disposal methods to protect the environment. Keep the medication away from children to prevent accidental contact or ingestion.

Following are the quick tips for Clobetasone Butyrate Ointment:

• Clean and dry the affected skin area before applying the ointment.
• Apply a thin layer of the ointment to the skin, gently rubbing it in.
• Wash your hands after applying, unless your hands are the treated area.
• Avoid applying the ointment near the eyes, mouth, or open wounds.
• Do not cover the treated area with bandages or dressings unless directed by your doctor.
• Inform your doctor if your condition doesn't improve or worsens after a few days of treatment.
• Store the ointment at room temperature, away from direct sunlight and moisture.