ENTAMIZOLE SUP

Diloxanide Furoate acts by interfering with the metabolic pathways of certain parasitic protozoa, primarily amoebas. It selectively inhibits the enzyme fumarate reductase within the parasite, disrupting its energy production and leading to its death. On the other hand, Metronidazole exerts its effect by disrupting the DNA structure of susceptible organisms, particularly anaerobic bacteria and protozoa. It is believed to enter the cells of these organisms and cause damage to their DNA, leading to cell death.

Antiprotozoal

Tablet

The following are the uses of Diloxanide Furoate, Metronidazole Tablet:

• Used for treating intestinal amoebiasis
• Used to eliminate amoebic cysts in the intestine
• Used to treat infections caused by anaerobic bacteria and certain parasites
• Used for gastrointestinal infections, particularly in the colon
• Used for infections such as bacterial vaginosis and trichomoniasis
• Used for inflammatory conditions like ulcerative colitis and Crohn's disease
• Used for skin and soft tissue infections

In the case of an overdose of Diloxanide Furoate or Metronidazole Tablets, the severity of symptoms can vary. For Diloxanide Furoate, symptoms may include gastrointestinal disturbances and, in severe cases, central nervous system effects. Metronidazole overdose can lead to nausea, vomiting, and a metallic taste in the mouth, along with more serious neurological symptoms such as seizures or peripheral neuropathy. Prompt medical evaluation is necessary to manage potential complications and provide appropriate treatment.

In the case of a missed dose of Diloxanide Furoate, take the missed dose as soon as you remember. If it's almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. For Metronidazole Tablet, if you miss a dose, take it as soon as you remember. However, if it's close to the time for your next dose, skip the missed dose and continue with your regular dosing regimen. Do not double the dose to make up for a missed one for either medication.

To take Diloxanide Furoate and Metronidazole Tablets, swallow the tablets whole with a full glass of water, preferably during or after a meal, following the dosage instructions provided by your healthcare professional, ensuring you complete the full course of medication as prescribed.

Following are the conditions/situations when Diloxanide Furoate and Metronidazole Tablet should not be used:

• Not recommended for individuals with a known allergy to either Diloxanide Furoate or Metronidazole or any other similar antibiotics.
• Contraindicated in patients with a history of blood disorders or central nervous system diseases.
• Should not be used in patients with severe liver impairment.
• Not suitable for individuals with a history of seizures or epilepsy.
• Avoid in patients with a history of peripheral neuropathy.
• Must not be used in patients with a known sensitivity to any of the tablet's components.
• Contraindicated during the first trimester of pregnancy and in breastfeeding mothers.
• Not recommended for children under 12 years of age.
• Avoid in patients with a history of porphyria.
• Should not be used in patients with a history of severe kidney disease.

The side effects of Diloxanide Furoate and Metronidazole Tablet may include:

• Nausea and vomiting
• Metallic taste in the mouth
• Dry mouth
• Loss of appetite
• Dizziness
• Headache
• Darkening of urine
• Diarrhea

Following are the precautions and warnings for Diloxanide Furoate, Metronidazole Tablet:

• Do not take this medication if you have a known allergy to Diloxanide Furoate or Metronidazole or any other ingredients in the tablet.
• Patients with liver or kidney disease should use this medication with caution as it may require dosage adjustments.
• Avoid alcohol consumption while taking this medication, as Metronidazole can cause severe reactions when combined with alcohol.
• This medication may cause dizziness or lightheadedness, so avoid activities that require alertness until you know how it affects you.
• Do not take this medication if you are pregnant or breastfeeding without consulting your doctor, as it may harm the fetus or infant.
• Inform your doctor if you have any other medical conditions, especially gastrointestinal disorders, as this medication may worsen certain conditions.
• Diloxanide Furoate, Metronidazole Tablet should be used with caution in children, and the dosage should be determined by a healthcare professional.
• Do not share this medication with others, even if they have similar symptoms, as it may be harmful to those for whom it has not been prescribed.

Following are the drug interactions for Diloxanide Furoate and Metronidazole Tablet:

• Alcohol consumption should be avoided as it may cause a disulfiram-like reaction, leading to nausea, vomiting, and abdominal discomfort.
• Concomitant use with anticoagulants like warfarin may require monitoring of international normalized ratio (INR) due to potential changes in anticoagulant effects.
• Metronidazole may decrease the effectiveness of oral contraceptives, requiring additional contraceptive measures.
• It can interact with lithium, increasing lithium levels and the risk of lithium toxicity.
• Drugs metabolized by the liver may have altered effects when taken with Metronidazole, as it can affect liver enzymes.
• Diloxanide Furoate may reduce the absorption of other medications, especially those requiring an acidic environment for absorption.
• Caution is advised when combining with other antibiotics, as it may increase the risk of antibiotic-associated colitis.

Following are the food interactions for Diloxanide Furoate and Metronidazole Tablet:

• Alcohol consumption should be avoided during and for at least 24 hours after completing the treatment with Metronidazole to prevent a disulfiram-like reaction, which can cause symptoms like flushing, nausea, and increased heart rate.
• Grapefruit and grapefruit juice should be avoided as they may interfere with the metabolism of Metronidazole, potentially leading to increased side effects.
• Dairy products like milk, yogurt, and cheese can reduce the absorption of Metronidazole, so it is best to take the medication at least an hour before or two hours after consuming dairy.
• Diloxanide Furoate is generally well-tolerated, but to ensure optimal absorption, it is advisable to take it on an empty stomach, at least one hour before or two hours after meals.
• Avoid consuming high-fat meals while taking Diloxanide Furoate, as it may slow down the absorption of the medication.
• There are no specific food restrictions for Diloxanide Furoate, but maintaining a balanced diet and staying hydrated is recommended during treatment.
• Avoid caffeine-containing beverages like coffee, tea, and energy drinks, as they may aggravate gastrointestinal symptoms while taking Metronidazole.

Diloxanide Furoate and Metronidazole Tablets should be stored in a dry and cool environment, preferably at room temperature, ensuring protection from light and moisture. These tablets should be kept in their original packaging, tightly sealed, to maintain their integrity and effectiveness. When disposing of any unused or expired medication, it is crucial to avoid flushing them down the toilet or pouring them into drains. Instead, consult a pharmacist or healthcare professional for appropriate disposal methods to prevent environmental contamination. Always keep medicines away from children to prevent accidental ingestion, and remember to check the expiration date before use. Proper storage and disposal practices are essential to maintain the quality and safety of these medications.

Following are the quick tips for Diloxanide Furoate and Metronidazole Tablet:

• Consult a doctor for prescription and dosage instructions.
• Swallow the tablet whole with water; do not crush or chew.
• Take the medication at evenly spaced intervals for consistent benefits.
• Complete the full course of treatment, even if you feel better early on.
• Avoid alcohol consumption while using Metronidazole to prevent adverse reactions.
• Store in a cool, dry place, away from sunlight and moisture.
• Inform your doctor of any allergies or medical conditions before use.