ENTSTA 10MG TAB

Entacapone's primary mechanism of action is as a selective and potent inhibitor of the enzyme catechol-O-methyltransferase (COMT). It works by blocking the action of COMT, which is responsible for breaking down dopamine, a neurotransmitter in the brain. By inhibiting COMT, entacapone prolongs the effects of dopamine in the brain, particularly in the areas involved in movement control. This inhibition leads to increased levels of dopamine in the synaptic cleft, enhancing dopaminergic neurotransmission. Specifically, entacapone prevents the degradation of levodopa, a dopamine precursor, allowing for more levodopa to be converted into dopamine. This mechanism is particularly beneficial in the treatment of Parkinson's disease, as it improves the effectiveness of levodopa therapy by increasing the duration and magnitude of dopamine response, thereby improving motor symptoms and overall motor function.

Entacapone

Catechol-O-methyltransferase (COMT) inhibitor.

Tablet

The following are the uses of Entacapone Tablet:

• Used for treating Parkinson's disease by boosting the effects of levodopa, improving muscle control.
• Used to enhance dopamine action in the brain, aiding movement and reducing stiffness.
• Used to manage motor fluctuations in Parkinson's patients, providing more consistent symptom control.
• Used to prolong the effectiveness of each levodopa dose, reducing the frequency of medication.
• Used to improve daily living activities and quality of life for Parkinson's patients.
• Used as an adjunct therapy, working alongside other medications for better overall management.
• Used to reduce "wearing off" symptoms, ensuring stable treatment outcomes.

In the case of an overdose of Entacapone Tablets, individuals may experience symptoms such as nausea, vomiting, abdominal pain, and increased muscle movements. The severity of these symptoms can vary depending on the amount ingested. It is important to promptly seek medical advice if an overdose is suspected. Treatment for overdose may involve supportive care and management of symptoms, ensuring the patient's safety and well-being. Prompt action and medical guidance are essential in such situations.

In the case of a missed dose of Entacapone Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, consult your healthcare professional for advice on how to get back on track with your medication regimen safely. It is crucial to maintain a consistent medication routine for optimal treatment results.

To take Entacapone Tablets, swallow the tablet whole with a full glass of water, usually three to four times a day, approximately 30 minutes before meals or as directed by your healthcare professional, ensuring adherence to the prescribed dosage.

Following are the conditions or circumstances when Entacapone Tablet should not be taken:

• Avoid using if you have a known allergy or hypersensitivity to Entacapone or any other related compounds.
• Not suitable for individuals with severe liver disease or impaired liver function.
• Should not be taken if you have a history of severe skin reactions or rashes to similar medications.
• Contraindicated in patients with a history of neuroleptic malignant syndrome (NMS), a rare but serious side effect of certain medications.
• Avoid using Entacapone if you have a history of low blood pressure or orthostatic hypotension.
• Not recommended for individuals with a history of certain eye conditions, such as narrow-angle glaucoma.
• Discontinue use if you experience involuntary movements (dyskinesia) as a side effect.

The side effects of Entacapone Tablet may include:

• Nausea and vomiting
• Diarrhea
• Dizziness or lightheadedness
• Headache
• Sleep disturbances (insomnia or vivid dreams)
• Muscle stiffness or twitching
• Urinary tract infections
• Confusion or hallucinations (more common in elderly patients)

Following are the precautions and warnings for Entacapone Tablet:

• This medication is intended for patients with Parkinson's disease and should not be used by individuals without this condition.
• Patients with a history of liver or kidney disease should exercise caution and inform their healthcare provider, as Entacapone may require dosage adjustments in such cases.
• Entacapone can cause drowsiness or dizziness; patients should avoid driving, operating heavy machinery, or engaging in activities that require mental alertness until they know how the medication affects them.
• It may cause involuntary movements (dyskinesia); if this occurs, patients should seek medical advice.
• Elderly patients may be more sensitive to the effects of Entacapone, and dosage adjustments might be necessary.
• Patients with a history of melanoma or other skin cancers should be monitored closely, as Entacapone may increase the risk of developing new skin cancers.
• This medication may cause urine to turn dark in color, which is a harmless side effect.

Following are the drug interactions for Entacapone Tablet:

• Iron supplements can reduce the absorption of Entacapone, leading to decreased effectiveness. Separate the doses by at least 2-3 hours.
• When combined with Levodopa/Carbidopa, Entacapone may increase the risk of involuntary movements (dyskinesia). Close monitoring is necessary.
• The risk of adverse cardiovascular events may be elevated when Entacapone is used with Catechol-O-methyltransferase (COMT) inhibitors.
• Taking Entacapone with Metoclopramide may reduce the effectiveness of Entacapone due to its effects on gastric emptying.
• Entacapone can interact with certain antipsychotic medications, increasing the risk of neurological side effects and movement disorders.
• Caution is advised when using Entacapone with drugs that increase the risk of bleeding, as it may enhance this effect.
• Some medications metabolized by the liver may have their blood levels affected by Entacapone, potentially requiring dosage adjustments.

Following are the food interactions to consider with Entacapone Tablet:

• Grapefruit juice should be consumed with caution as it may affect the metabolism of Entacapone, potentially leading to increased levels in the body.
• High-protein meals can reduce the absorption of Entacapone, so it is best to take the medication on an empty stomach or with a low-protein meal.
• Avoid excessive caffeine intake as it may interact with Entacapone, potentially causing increased nervousness and restlessness.
• Alcohol may increase the risk of side effects and should be consumed in moderation or avoided while taking Entacapone.
• Foods rich in tyramine, such as aged cheeses, cured meats, and certain types of beer, should be limited as they may interact with Entacapone and increase blood pressure.
• Avoid high-fat meals as they can delay the absorption of Entacapone, potentially reducing its effectiveness.
• Consult your healthcare provider about any specific dietary restrictions or recommendations, especially if you have a history of gastrointestinal issues.

Entacapone Tablets should be stored in a cool, dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Protect the tablets from light and moisture by keeping them in their original container, tightly sealed. Avoid storing them in the bathroom or kitchen, as these areas can be prone to temperature fluctuations and humidity. Always check the expiration date, and do not use the medication if it is past this date. For disposal, do not throw the tablets into the garbage or flush them down the toilet. Instead, follow local guidelines for medication disposal or consult your pharmacist for advice on how to safely and responsibly dispose of unused or expired Entacapone Tablets. Keep the medication away from children and pets to prevent accidental ingestion.

Following are the quick tips for Entacapone Tablet:

• Always take the tablet as directed by your physician.
• Maintain a consistent medication schedule by taking it at the same time each day.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• You can take it with or without food, but be consistent with your choice.
• If you experience nausea, taking it with food may help alleviate this side effect.
• Ensure you stand up slowly from a sitting or lying position to prevent dizziness.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.