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Epicar (200mg) 50 Tablets
- Manufacturer Adamjee Pharmaceuticals (Pvt.) Ltd.
- Generic Name Carbamazepine
Healthwire Pharmacy Ratings & Reviews (1500+)
Product Information
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Description
Carbamazepine is an anticonvulsant that works by stabilizing hyperexcited nerve membranes. It primarily blocks voltage-gated sodium channels, preventing the propagation of abnormal electrical activity in the brain, thus reducing seizure frequency and intensity.
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Ingredients
Carbamazepine -
Drug Class
Anticonvulsant
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Dosage Form
Tablet
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Uses
This medication is used for:
• Prophylaxis of manic depressive psychosis unresponsive to lithium
• Epilepsy
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Dosage
Carbamazepine dosage for the indication of epilepsy and bipolar disorder, with long-term duration:
- Adults - 200-400 mg twice daily. Max - 1,600 mg/day.
- Children - (6-12 years) 100-200 mg twice daily, (<6 years) 10-20 mg/kg/day.
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In case of Overdose
Overdose can lead to severe neurological and gastrointestinal symptoms. Immediate medical attention is required.
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Missed Dose
If you miss a dose, consume as soon as you remember. If it is close to the next feeding, skip the missed dose. Do not double up on doses.
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How To Use
Taken orally with food, typically in divided doses. Follow the prescribed dosage and frequency.
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When Not to Use
Carbamazepine should not be used if:
- Hypersensitivity
- Severe liver impairment
- Concurrent use with MAO inhibitors
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Side Effects
Unraveling the side effects lurking behind this product are the following:
• Gastric upset
• Ataxia
• Fatigue
• Headache
• Visual disturbances
• Weight gain
• Raised liver function tests (LFTs)
• Diplopia
• Dry mouth
• Drowsiness
• Dizziness
• Edema
• Rarely hyponatremia
• Blood dyscrasias
• Rashes
• Toxic epidermal necrolysis
• Hair loss
• Acute renal failure
• Lymph-node enlargement
• Cardiac conduction disturbances
• Angioedema
• Pancreatitis
• Hepatitis
• Cholestatic jaundice
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Precautions & Warnings
It should be used with caution in patient with Severe CVS disease. Hepatic or renal disorders. Elderly. Perform liver function tests and check blood count regularly. Glaucoma, previous psychosis, mixed seizures. Maintain adequate intake of vit D. Risk of serious skin reactions.
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Drug Interactions
The drug interactions with carbamazepine include:
- CYP3A4 Inducers (e.g., rifampin) – Can decrease carbamazepine levels.
- CYP3A4 Inhibitors (e.g., ketoconazole) – Can increase carbamazepine levels.
- Other Anticonvulsants (e.g., phenytoin) – Can alter carbamazepine levels.
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Food Interactions
For Carbamazepine, food interactions that should be considered are:
- Taking with food may help reduce gastrointestinal side effects.
- Avoid grapefruit juice as it may increase drug levels.
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Storage/Disposal
Carbamazepine should be stored at room temperature, away from light and moisture. Keep it in its original container and out of reach of children. Dispose of expired or unused Carbamazepine according to local disposal guidelines or through a drug take-back program.
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