Epicetam (500mg/5ml) 1 Ampoule Injection

Levetiracetam's mechanism of action is primarily believed to involve binding to synaptic vesicle protein 2A (SV2A) in the brain, although the exact process through which it exerts its antiseizure effects is not fully understood. This binding is thought to modulate neurotransmitter release and inhibit neuronal hyperexcitability, thereby stabilizing abnormal electrical activity in the brain. By interacting with SV2A, Levetiracetam may help reduce the frequency of seizures, making it effective in managing certain types of epilepsy. This mechanism highlights a unique approach to controlling seizures compared to other traditional antiepileptic medications.

Levetiracetam 500mg

Anticonvulsant

Injection

The following are the uses of Levetiracetam 500mg injection:

• Used for treating epilepsy and reducing the frequency of seizures.
• Used for managing partial-onset seizures, both alone and in combination with other medications.
• Used for controlling seizures in adults and children with certain types of epilepsy.
• Used for improving seizure control when other medications are not effective.
• Used for reducing the occurrence of seizures associated with specific neurological conditions.
• Used for providing rapid control of seizures in emergency situations.
• Used for facilitating the transition from oral to intravenous medication during medical procedures.

One injection per day is recommended. Follow your doctor's instructions.

In the case of an overdose of Levetiracetam 500mg injection, it is important to recognize the potential symptoms, which may include extreme drowsiness, weakness, and coordination difficulties. Prompt medical attention is necessary, and healthcare professionals should be informed about the suspected overdose. They will closely monitor vital signs and may administer supportive care to manage any adverse effects. Treatment may involve symptomatic and supportive measures to ensure the patient's safety and well-being.

In the case of a missed dose of Levetiracetam 500mg injection, it is important to administer the medication as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed and to determine if any adjustments to your treatment plan are necessary. Always store the medication as directed and keep a record of any missed doses.

To administer Levetiracetam 500mg injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and slowly inject the medication into the muscle, ensuring the entire dose is delivered before withdrawing the needle.

Here are the conditions or situations when Levetiracetam 500mg injection should not be used:

• Should not be administered to patients with a history of hypersensitivity or allergic reactions to Levetiracetam or any of the excipients in the formulation.
• Contraindicated in patients with severe kidney disease or those on dialysis, as dosage adjustments are necessary.
• Not recommended for patients with a history of liver impairment or active liver disease.
• Should be avoided in patients with a history of blood disorders or a significant decrease in white blood cell count.
• Not suitable for patients with a history of psychiatric disorders, unless closely monitored by a healthcare professional.
• Should not be used in patients with a history of respiratory depression or severe respiratory conditions.
• Contraindicated during breastfeeding, as Levetiracetam may pass into breast milk and potentially harm the nursing infant.

The side effects of Levetiracetam 500mg Injection may include:

• Dizziness and weakness
• Fatigue and drowsiness
• Headache
• Behavioural changes, such as aggression, anger, or depression
• Nausea and vomiting
• Skin rash or itching
• Loss of appetite
• Impaired coordination

Following are the precautions and warnings for Levetiracetam 500mg Injection:

• This medication should not be administered to individuals with a known hypersensitivity or allergy to Levetiracetam or any of its excipients.
• Levetiracetam may cause dizziness or drowsiness; patients should avoid driving, operating heavy machinery, or engaging in activities requiring mental alertness until they know how the medication affects them.
• Caution is advised in patients with a history of kidney or liver disease, as dosage adjustments may be necessary.
• Regular monitoring of kidney function and liver enzymes is recommended during long-term treatment.
• Patients with a history of mental health disorders, including depression or suicidal thoughts, should be closely monitored while on this medication.
• Levetiracetam should be used with caution in elderly patients, as they may be more susceptible to side effects.
• It is important to inform your healthcare provider about all medications you are currently taking to avoid potential drug interactions.
• This medication should be used during pregnancy and breastfeeding only if the potential benefits outweigh the risks, and under the supervision of a healthcare professional.

Following are the drug interactions for Levetiracetam 500mg injection:

• Phenytoin, carbamazepine, and other enzyme-inducing antiepileptic drugs may decrease levetiracetam levels, possibly requiring dosage adjustments.
• Levetiracetam may increase the concentration of primidone and phenobarbital, which could lead to enhanced side effects.
• Concomitant use with warfarin may increase the risk of bleeding, so monitoring of INR (International Normalized Ratio) is recommended.
• The effectiveness of hormonal contraceptives may be reduced, so alternative methods are advised.
• Levetiracetam can increase the effects of alcohol and other CNS depressants, such as benzodiazepines, leading to enhanced sedation and impaired motor skills.
• Digoxin levels may be increased, requiring monitoring and potential dosage adjustments.
• Probenecid may reduce the renal clearance of levetiracetam, potentially increasing its concentration in the body.

Following are the food interactions for Levetiracetam 500mg injection:

• Avoid consuming alcohol during the treatment with Levetiracetam as it may increase the risk of side effects and affect the central nervous system.
• Grapefruit and grapefruit juice should be consumed with caution as they can influence the metabolism of the drug, potentially altering its effectiveness.
• Levetiracetam can be taken with or without food, but maintaining a consistent routine is advisable to ensure optimal absorption.
• No significant interactions have been reported with specific foods, allowing patients to continue their regular diet.
• It is advisable to stay well-hydrated during the treatment period to support overall health and medication effectiveness.
• Avoid caffeine or reduce its intake as it may exacerbate certain side effects such as nervousness, tremors, and sleep disturbances.
• Always follow the dietary recommendations provided by your healthcare professional for the best outcomes.
• Consult your doctor or pharmacist if you have any concerns about potential food interactions.

Levetiracetam 500mg injection should be stored in a controlled environment, preferably in a cool and dry place at room temperature (between 20-25°C). Protect the injection from light and moisture by keeping it in its original packaging until use. Ensure the medication is stored away from heat sources like radiators or direct sunlight, as temperature fluctuations can impact its effectiveness. Always check the expiration date, and never use the injection if it is expired. When disposing of the medication, do not flush or pour it down the drain; instead, follow local guidelines for pharmaceutical waste disposal or consult a healthcare professional for guidance on proper disposal methods. Keep the injection out of children's reach to prevent accidental exposure.

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Following are the quick tips for Levetiracetam 500mg injection:

• Ensure the injection is administered by a trained healthcare professional.
• Verify the patient's identity and confirm the prescribed dosage before injection.
• Inject the medication slowly, as directed, to minimize discomfort.
• Use a clean, dry injection site and practice proper injection technique.
• Rotate injection sites to reduce the risk of skin irritation.
• Do not mix Levetiracetam with other medications unless instructed by a doctor.
• Report any side effects or changes in health status to your healthcare provider promptly.
• Store the injection at room temperature, away from direct sunlight and moisture.