Epilim EC200 (200mg) 100 Tablets

Sodium valproate 200mg tablets primarily exert their therapeutic effects through multiple mechanisms of action in the brain. The primary mechanism is believed to be the enhancement of gamma-aminobutyric acid (GABA) activity, an inhibitory neurotransmitter in the central nervous system. Sodium valproate inhibits GABA transaminase, an enzyme responsible for breaking down GABA, leading to increased GABA levels in the brain. This increased GABA activity helps to reduce excessive neuronal firing and stabilize over-excited neural networks, resulting in anticonvulsant, mood-stabilizing, and migraine-preventive effects. Additionally, sodium valproate may block sodium channels, inhibit T-type calcium channels, and modulate the release of excitatory neurotransmitters, further contributing to its therapeutic actions.

Anticonvulsant/Mood Stabilizer

Tablet

The following are the uses of sodium valproate 200mg Tablet:

• Used for controlling and preventing seizures in various types of epilepsy.
• Used for treating manic episodes in bipolar disorder, helping to stabilize mood.
• Used as a migraine prophylactic to reduce the frequency and severity of migraine attacks.
• Used for treating acute manic or mixed episodes in bipolar disorder, providing short-term relief.
• Used for managing certain types of seizures, such as absence seizures and complex partial seizures.
• Used as a long-term treatment to help prevent the recurrence of manic episodes in bipolar disorder.
• Used in combination with other medications to enhance seizure control in complex epilepsy cases.

In the case of an overdose of Sodium Valproate 200mg tablets, symptoms may include extreme drowsiness, loss of consciousness, respiratory depression, and even coma. The severity of the overdose depends on the amount ingested. It can lead to a rapid decrease in blood pressure, causing dizziness and fainting. Nausea, vomiting, and abdominal pain may also occur. Prompt medical attention is necessary, and individuals should seek emergency care if they suspect an overdose, especially if they experience any of these symptoms.

In the case of a missed dose of sodium valproate 200mg Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to restart the medication or adjust the dosage accordingly. It is important to maintain a consistent medication routine for optimal effectiveness.

To administer the sodium valproate 200mg tablet, take the prescribed dose orally with a full glass of water, preferably with food to reduce the risk of gastrointestinal discomfort. Swallow the tablet whole without crushing or chewing unless directed otherwise by a healthcare professional.

Here are the conditions or situations when Sodium Valproate 200mg Tablet should not be used:

• Must not be taken by individuals with a known allergy to sodium valproate or any of its ingredients.
• Contraindicated in patients with liver disease, severe liver impairment, or active liver disease.
• Should not be used by individuals with a known urea cycle disorder.
• Not suitable for patients with a personal or family history of hepatic porphyria.
• Contraindicated in patients with mitochondrial disorders, especially mitochondrial polymerase γ (POLG) mutations.
• Should not be used by women who are pregnant or planning to become pregnant, unless the potential benefits outweigh the risks.
• Not recommended for individuals with a history of pancreatitis.
• Should be avoided in patients with a history of thrombocytopenia or other blood disorders.
• Contraindicated in patients with a history of hypersensitivity reactions to anticonvulsant drugs.

The side effects of Sodium Valproate 200mg Tablet may include:

• Nausea and vomiting
• Weight gain
• Tremors or shaking
• Hair loss
• Dizziness or drowsiness
• Stomach pain or indigestion
• Weakness or fatigue
• Skin rashes or itching

Following are the precautions and warnings for Sodium Valproate 200mg Tablet:

• This medication should be used with caution in patients with liver or kidney disease, as it may require dose adjustments.
• Regular monitoring of liver function is necessary, and immediate medical attention should be sought if symptoms of liver problems occur.
• Sodium Valproate can cause pancreatitis, so watch for symptoms like severe abdominal pain, nausea, and vomiting.
• It may cause dizziness and drowsiness, so patients should avoid driving or operating machinery until they know how the medication affects them.
• Patients with a history of brain disorders or seizures should inform their doctor, as this medication may affect their condition.
• Inform your doctor about all medications you are taking to avoid potential drug interactions.
• Sodium Valproate may cause behavioral changes, and patients should be monitored for mood swings, depression, or suicidal thoughts.

Following are the drug interactions for Sodium Valproate 200mg Tablet:

• Carbapenem antibiotics (like Imipenem) may decrease the effectiveness of Sodium Valproate, possibly leading to breakthrough seizures.
• Combining with Aripiprazole may increase the risk of extrapyramidal symptoms.
• Concomitant use with other central nervous system (CNS) depressants (e.g., benzodiazepines, barbiturates) can enhance sedation and respiratory depression.
• Sodium Valproate may reduce the plasma levels of Lamotrigine, potentially decreasing its efficacy.
• It can increase the concentration of Lorazepam, enhancing its sedative effects.
• The effectiveness of oral contraceptives may be reduced, increasing the risk of unintended pregnancy.
• Topiramate may increase the clearance of Sodium Valproate, potentially reducing its therapeutic effect.

Following are the food interactions for Sodium Valproate 200mg Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as they can alter the metabolism of sodium valproate, potentially leading to increased drug levels in the body and a higher risk of side effects.
• Alcohol intake is not recommended as it can enhance the sedative effects of sodium valproate, increasing the likelihood of dizziness, drowsiness, and impaired coordination.
• High-protein meals may reduce the absorption of sodium valproate. It is advisable to maintain a consistent diet to ensure stable drug levels.
• Fatty foods can delay the absorption of sodium valproate, potentially affecting its effectiveness.
• Avoid consuming large amounts of caffeine, as it can increase the metabolism of sodium valproate, leading to reduced drug levels.
• Certain high-carbohydrate diets may impact the absorption of sodium valproate. Consult your healthcare provider for dietary advice.
• Avoid excessive salt intake as sodium valproate contains sodium, and high sodium levels can have health implications.
• Always consult your healthcare provider for specific dietary recommendations and adjustments while taking sodium valproate.

Sodium Valproate 200mg Tablets should be stored in a cool and dry place, preferably at room temperature, away from direct sunlight and moisture. Keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain their integrity. Avoid exposing the medication to extreme temperatures, including heat sources like ovens or radiators, as this can impact its effectiveness. When disposing of unused or expired tablets, do not flush them or pour them down the drain. Instead, consult a pharmacist or healthcare professional for appropriate disposal methods to ensure environmental safety. It is crucial to keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Sodium Valproate 200mg Tablet:

• Take the tablet as directed by your doctor; do not alter the dosage without medical advice.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Take it consistently at the same time each day to maintain stable blood levels.
• It can be taken with or without food, but taking it with food may reduce stomach upset.
• Avoid alcohol consumption while on this medication as it can increase side effects.
• Inform your doctor about all medications you're taking to prevent drug interactions.
• Store the tablets at room temperature, away from moisture and light.