Eplarox-150 (150mg) 10 Tablets

Roxithromycin 150mg Tablet, a semi-synthetic macrolide antibiotic, exerts its bactericidal effect by primarily inhibiting bacterial protein synthesis. It achieves this by binding to the 50S subunit of the bacterial ribosome, thereby preventing the translocation of aminoacyl-tRNA and hindering the formation of peptide bonds essential for protein assembly. This interference in protein synthesis specifically targets bacterial cells as it selectively binds to the distinct ribosomal subunits found in bacteria, leading to their growth inhibition and eventual death. Roxithromycin's mechanism of action is particularly effective against a broad spectrum of bacteria, including Streptococcus pneumoniae, Haemophilus influenzae, and Mycoplasma pneumoniae, making it a valuable therapeutic agent in the treatment of various respiratory tract infections.

Macrolide antibiotic.

Tablet

The following are the uses of Roxithiromycin 150mg Tablet:

• Used for treating bacterial infections, particularly respiratory tract infections like pneumonia and bronchitis.
• Used for effectively treating acute sinusitis, ensuring quick relief.
• Used for managing skin and soft tissue infections, promoting healing.
• Used for preventing and controlling chest infections in those prone to recurrent issues.
• Used for improving respiratory health and reducing inflammation.
• Used for treating mild to moderate infections caused by susceptible bacteria.
• Used for providing targeted relief from bacterial infections with minimal side effects.
• Used for supporting the immune system's fight against bacterial pathogens.

In the case of an overdose of Roxithromycin 150mg Tablets, the primary concern is the potential for gastrointestinal side effects. Symptoms may include nausea, vomiting, diarrhea, and abdominal pain. It is important to contact a healthcare professional or seek medical advice immediately if an overdose is suspected. Prompt medical intervention can help manage these symptoms and prevent any potential complications. Treatment may involve supportive care and monitoring to ensure the patient's well-being.

In the case of a missed dose of Roxithromycin 150mg Tablet, it is important to take the medication as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently forget doses, consider setting an alarm or asking a family member to remind you to take your medication at the correct time. It is crucial to maintain a consistent dosing routine for the medication's effectiveness.

To take Roxithromycin 150mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, either with or without food, as directed by your healthcare professional.

Following are the conditions when Roxithromycin 150mg Tablet should not be taken:

• Avoid if you have a known allergy or hypersensitivity to Roxithromycin or any other macrolide antibiotics.
• Do not take if you have a history of liver problems or jaundice caused by previous Roxithromycin use.
• Contraindicated in individuals with severe kidney impairment or those on dialysis.
• Should not be used in patients with a prolonged QT interval or a history of irregular heart rhythms.
• Not suitable for children weighing less than 40 kg.
• Avoid if you have myasthenia gravis, as it may worsen muscle weakness.
• Do not use if you are taking certain medications that may interact with Roxithromycin, such as ergot alkaloids or certain anti-arrhythmic drugs.

The side effects of Roxithromycin 150mg Tablet may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Skin rash or itching
• Dizziness
• Headache
• Altered taste
• Fatigue

Following are the precautions and warnings for Roxithromycin 150mg Tablet:

• This medication should be used with caution in patients with liver or kidney disease, as it may require dosage adjustments or close monitoring.
• Roxithromycin may cause prolonged QT intervals, so it should be used with caution in patients with a history of heart disease or those taking other medications that can affect heart rhythm.
• Patients should inform their doctor about all medications they are currently taking, especially those that may interact with Roxithromycin, such as antacids, ergotamine, and certain antiarrhythmic drugs.
• Avoid excessive exposure to sunlight or UV rays while taking this medication, as it may increase photosensitivity.
• Do not take Roxithromycin if you have a history of allergic reactions to macrolide antibiotics.
• Patients with myasthenia gravis should exercise caution as Roxithromycin may worsen muscle weakness.
• This medication may cause diarrhea, and in rare cases, it can be a sign of a new infection. Consult a doctor if diarrhea becomes severe or persistent.
• Roxithromycin should be used during pregnancy and breastfeeding only if clearly needed and under the supervision of a healthcare professional.

Following are the drug interactions for Roxithromycin 150mg Tablet:

• May interact with antacids containing aluminum or magnesium, reducing Roxithromycin's absorption. It is recommended to take Roxithromycin at least 2 hours before or after antacids.
• Roxithromycin can increase the concentration of certain statins (e.g., simvastatin, lovastatin), potentially leading to an increased risk of muscle-related side effects.
• The effectiveness of oral contraceptives may be reduced when taken with Roxithromycin, due to altered metabolism. Additional contraceptive methods are advised during treatment.
• Ergot alkaloids (e.g., ergotamine, dihydroergotamine) can interact with Roxithromycin, potentially causing ergotism, a serious condition affecting blood vessels and nerves.
• Warfarin and other anticoagulants may have their effects enhanced by Roxithromycin, increasing the risk of bleeding. Regular monitoring of coagulation parameters is necessary.
• Digoxin levels may be increased when used with Roxithromycin, leading to potential digoxin toxicity. Monitoring of digoxin levels is recommended.
• Roxithromycin can affect the metabolism of various medications, including benzodiazepines, ciclosporin, and theophylline, potentially altering their effectiveness and side effect profile.

Following are the food interactions for Roxithromycin 150mg Tablet:

• Avoid grapefruit and grapefruit juice as they can increase the levels of the drug in the blood, leading to potential side effects.
• Alcohol consumption should be minimized or avoided as it may increase the risk of liver-related side effects.
• High-fat meals can delay the absorption of Roxithromycin, so it is best to take the medication on an empty stomach.
• Dairy products like milk, cheese, and yogurt may reduce the absorption of the medicine, so it's advisable to separate them by a few hours.
• Avoid black carrot juice as it may reduce the effectiveness of the medication.
• Consuming foods rich in calcium, magnesium, and aluminum (antacids) close to taking the medicine may decrease its absorption.
• Vitamin K-rich foods like leafy greens might interfere with the medication's effect on blood clotting.
• There is no significant interaction with caffeine, but excessive consumption may cause nervousness and insomnia.

Roxithiromycin 150mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring it stays below 25°C. Protect the tablets from direct exposure to sunlight and moisture to maintain their integrity. Keep the medication in its original container, tightly sealed, to prevent contamination. Avoid placing the tablets in the bathroom or near heat-emitting appliances as temperature fluctuations can impact their effectiveness. When disposing of unused or expired tablets, do not flush them or pour them down the drain. Consult a pharmacist or healthcare professional for guidance on proper disposal methods. Additionally, exercise caution to keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Roxithromycin 150mg Tablet:

• Take the medicine as directed by your doctor; follow the prescription carefully.
• Complete the full course of medication, even if you feel better before it's finished.
• Swallow the tablet whole with a full glass of water; do not crush or chew.
• Take it on an empty stomach, at least 1 hour before or 2 hours after a meal.
• Avoid consuming grapefruit or grapefruit juice during treatment.
• Inform your doctor about all medications you're taking to prevent potential interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.