EPLAZYME CAP

Apixaban, the active ingredient in Apityzer capsules, is a selective and direct Factor Xa inhibitor. It exerts its anticoagulant effect by specifically blocking the active site of Factor Xa, thereby interrupting the intrinsic and extrinsic pathways of the coagulation cascade. By inhibiting Factor Xa, apixaban prevents the conversion of prothrombin to thrombin and subsequently inhibits the formation of fibrin clots. This mechanism helps prevent excessive blood clotting, making it useful in various thromboembolic disorders. The targeted action of apixaban on Factor Xa provides a predictable anticoagulant response and offers a safer alternative to traditional anticoagulants, as it has a lower potential for drug interactions and a reduced risk of bleeding complications.

Apityzer

Apixaban

Direct Factor Xa inhibitor.

Capsule

1

In the case of an overdose of Apityzer Capsules, it is important to recognize the signs and act promptly. Symptoms may include severe dizziness, fainting, difficulty breathing, and an irregular heartbeat. If you suspect an overdose, contact a healthcare professional or poison control center immediately. Quick action is essential, as overdoses can lead to serious health complications. It is crucial to keep medications out of reach of children and follow the prescribed dosage to prevent such incidents.

In the case of a missed dose of Apityzer Capsule, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication and ensure the best treatment outcome. It is recommended to set reminders to help you stay on track with your medication schedule.

To take Apityzer Capsule, swallow the capsule whole with a full glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, ensuring you do not crush, chew, or break the capsule to maintain its effectiveness.

Here are the circumstances where Apityzer Capsule should not be administered:

• Allergic reactions • Individuals with a known allergy to the active ingredient or any of the excipients in the capsule should avoid its use.
• Pregnancy • Contraindicated in pregnant women as it may cause harm to the developing fetus.
• Breastfeeding • Not recommended for breastfeeding mothers due to potential risks to the infant.
• Liver impairment • Should not be used in patients with severe liver disease or impaired liver function.
• Bleeding disorders • Contraindicated in individuals with active bleeding disorders or a history of bleeding problems.
• Recent surgery • Avoid use in patients who have undergone recent surgery or will undergo surgery soon.
• History of blood clots • Not suitable for individuals with a history of blood clots or thromboembolic disorders.
• Heart disease • Should not be used in patients with severe heart conditions or uncontrolled hypertension.

The side effects of Apityzer Capsule may include:

• Dry mouth
• Dizziness
• Headache
• Nausea and vomiting
• Diarrhea or constipation
• Fatigue and drowsiness
• Skin rashes or itching
• Difficulty sleeping

Following are the precautions and warnings for Apityzer Capsule:

• Not suitable for individuals with known allergies to any of its active or inactive ingredients.
• Should be used with caution in patients with liver or kidney disease, as dosage adjustments might be necessary.
• May cause drowsiness or dizziness, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Alcohol consumption should be avoided as it may increase the risk of side effects.
• Elderly patients may be more sensitive to the medication's side effects, requiring closer monitoring.
• Not recommended for children and adolescents under 18 years old without medical advice.
• Always inform your doctor about all medications you are currently taking to avoid potential drug interactions.

Following are the drug interactions for Apityzer Capsule:

• Concomitant use with Apixaban may increase the risk of bleeding. Regular monitoring is advised.
• Cytochrome P450 3A4 Inhibitors (e.g., Ketoconazole, Ritonavir). These drugs can increase the concentration of Apixaban, potentially leading to increased bleeding risk.
• May decrease Apixaban levels, reducing its effectiveness.
• Concurrent use may further increase the risk of bleeding.
• Similar to antiplatelet agents, NSAIDs can also enhance the risk of bleeding.
• The combination may have additive effects on coagulation, requiring close monitoring.
• Herbal supplements like Ginkgo biloba or garlic, These may increase bleeding risk.

Following are the food interactions for Apityzer Capsule:

• Grapefruit consumption should be limited as it can increase the levels of the drug in the blood, potentially leading to an increased risk of side effects.
• Alcohol intake should be avoided as it may enhance the sedative effects of the medication, causing excessive drowsiness and impaired coordination.
• Caffeine-rich beverages like coffee and energy drinks might interfere with the medication's action, leading to reduced effectiveness.
• High-fat meals may delay the absorption of the drug, potentially affecting its onset of action.
• Dairy products, particularly milk, can potentially decrease the absorption of the medication when consumed simultaneously.
• Consuming spicy foods may increase the risk of stomach irritation and worsen side effects such as heartburn or indigestion.
• Foods rich in vitamin K, like leafy greens, can potentially reduce the medication's effectiveness, especially in anticoagulant therapy.

The proper storage and disposal of Apityzer Capsules are crucial for maintaining their effectiveness and safety. Store the capsules in a cool, dry place, preferably at room temperature, away from direct sunlight and moisture. Keep the medication in its original container, tightly sealed, to ensure it remains protected from external contaminants. Avoid storing near heat sources like ovens or radiators as extreme temperatures can impact the medicine's quality. Always check the expiration date, and if the capsules are no longer needed or have expired, do not flush them or pour them down the drain. Consult a pharmacist or healthcare professional for guidance on safe disposal methods. Keep all medications securely stored and out of children's reach to prevent accidental consumption.

Here are the quick tips for Apityzer Capsule:

• Store capsules in a cool, dry place away from direct sunlight and moisture.
• Swallow the capsule whole with a full glass of water for easier swallowing.
• Take the capsule at the same time each day to maintain consistent blood levels.
• Avoid crushing, chewing, or breaking the capsule for optimal absorption.
• Inform your doctor if you have any allergies or medical conditions before taking this medication.
• Do not share this medication with others, even if their symptoms are similar.
• Contact your doctor if your symptoms persist or worsen while taking this medication.