Epuram (250/25/75mg) 40 Tablets

L-Arginine Monohydrochloride and L-citrulline work synergistically to enhance nitric oxide production in the body. L-Arginine is a precursor to nitric oxide, and when it is converted to L-citrulline in the urea cycle, it releases nitric oxide in the process. L-citrulline, in turn, can be recycled back to L-arginine, ensuring a continuous supply of this amino acid for nitric oxide synthesis. This increase in nitric oxide production leads to vasodilation, which improves blood flow and oxygen delivery to tissues. The mechanism involves the activation of nitric oxide synthase enzymes, which catalyze the conversion of L-arginine to citrulline, releasing nitric oxide as a byproduct. This process plays a crucial role in maintaining cardiovascular health and supporting various physiological functions.

L-Arginine Monohydrochloride 250mg, L-citrulline 75mg

Nitric oxide precursor

Tablet

The following are the uses of L-Arginine Monohydrochloride 250mg, L-citrulline 75mg Tablet:

• Used for improving blood flow and circulation
• Used to enhance exercise performance and muscle recovery
• Used for managing high blood pressure and cardiovascular health
• Used to support immune function and wound healing
• Used for treating erectile dysfunction and male infertility issues
• Used to improve kidney function and remove waste from the body
• Used to enhance protein synthesis and muscle growth

In the case of an overdose of L-Arginine Monohydrochloride 250mg and L-citrulline 75mg tablets, symptoms may include severe gastrointestinal distress, such as nausea, vomiting, and diarrhea. It can also lead to increased blood flow, resulting in headaches, dizziness, and potential cardiovascular issues. Seek medical advice promptly, and inform the healthcare professional about the specific substances and quantities involved in the overdose.

In the case of a missed dose of L-Arginine Monohydrochloride 250mg and L-citrulline 75mg Tablet, it is generally advised to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Avoid taking a double dose to make up for a missed one, as this may increase the risk of side effects. Consult your healthcare provider if you frequently miss doses or are unsure about how to manage missed doses.

To take the L-Arginine Monohydrochloride 250mg and L-citrulline 75mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Following are the conditions/situations when L-Arginine Monohydrochloride 250mg and L-citrulline 75mg Tablet should not be taken:

• Contraindicated in individuals with a known allergy to L-Arginine, L-citrulline, or any other ingredients in the formulation.
• Not suitable for patients with a history of recent heart attack or unstable angina.
• Should be avoided in people with severe liver or kidney disease.
• Not recommended for individuals with herpes virus or who have recently suffered from herpes outbreaks.
• Should not be used by patients with low blood pressure or those taking medications to lower blood pressure, as it may cause further drops in blood pressure.
• Contraindicated in individuals with gastrointestinal bleeding or those taking blood-thinning medications.

The side effects of L-Arginine Monohydrochloride 250mg and L-citrulline 75mg Tablet may include:

• Gastrointestinal issues such as nausea, vomiting, and diarrhea.
• Headaches and dizziness.
• Skin flushing or redness.
• Stomach pain or discomfort.
• Changes in blood pressure (either increase or decrease).
• Allergic reactions such as rash, itching, or swelling.
• Increased risk of bleeding, especially in individuals with bleeding disorders.
• Liver issues, including elevated liver enzymes.

Following are the precautions and warnings for L-Arginine Monohydrochloride 250mg, L-citrulline 75mg Tablet:

• This medication should be used with caution in patients with a history of gastrointestinal issues, as it may cause stomach upset, nausea, or diarrhea.
• Not suitable for individuals with a known allergy to L-arginine or L-citrulline, and immediate medical attention should be sought if an allergic reaction occurs.
• Patients with liver disease should exercise caution and consult a healthcare professional before use, as L-arginine may affect liver function.
• Those with a history of herpes outbreaks should be cautious, as L-arginine may potentially trigger or worsen outbreaks.
• Diabetic patients should monitor their blood sugar levels regularly, as L-arginine may affect glucose metabolism.
• Not recommended for children or adolescents without medical supervision, as safety and efficacy in this age group are not well-established.
• Pregnant and breastfeeding women should consult their doctor before taking this medication, as its effects on fetal development and nursing infants are not fully understood.

Following are the drug interactions for L-Arginine Monohydrochloride 250mg and L-citrulline 75mg Tablet:

• May interact with medications that lower blood pressure, such as nitrates and alpha-blockers, leading to a significant drop in blood pressure.
• Use with sildenafil or similar phosphodiesterase-5 (PDE5) inhibitors may increase the risk of hypotension and cardiovascular events.
• L-arginine can affect blood sugar levels, so caution is advised when used with diabetes medications.
• It can also interact with certain antibiotics, such as rifampin, and may decrease their effectiveness.
• The absorption of L-citrulline can be influenced by proton pump inhibitors (PPIs) and H2-receptor blockers, potentially reducing its effectiveness.
• L-arginine may interact with anticoagulants, increasing the risk of bleeding. Monitoring is recommended.
• Consult a healthcare professional before using L-arginine with herbal supplements like Ginkgo biloba or garlic, as it may affect blood clotting.

Following are the food interactions for L-Arginine Monohydrochloride 250mg and L-citrulline 75mg Tablet:

• L-Arginine and L-Citrulline can be affected by a high-protein diet, which may impact their effectiveness. It's advisable to maintain a balanced diet.
• Avoid excessive consumption of high-arginine foods like red meat, poultry, fish, and dairy products, as it can lead to increased arginine levels in the body.
• Consuming foods rich in citrulline, such as watermelon, cucumber, and pumpkin seeds, can naturally boost citrulline levels, potentially affecting the medication's efficacy.
• Grapefruit and grapefruit juice should be consumed cautiously as they may interfere with blood pressure regulation due to their impact on nitric oxide production.
• Alcohol may negatively impact the effectiveness of L-Arginine and L-Citrulline, potentially reducing their absorption and overall benefits.
• Caffeine may interact with L-Arginine, affecting blood pressure and heart rate, so monitor intake of coffee, tea, and energy drinks.
• Maintaining a healthy diet with a variety of fruits, vegetables, and whole grains can support the overall benefits of these supplements.
• Always consult a healthcare professional for personalized advice regarding diet and medication interactions.

L-Arginine Monohydrochloride 250mg, L-citrulline 75mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. It is crucial to keep the tablets in their original packaging, tightly sealed, to maintain their integrity and prevent contamination. Avoid exposing the medication to extreme temperatures, such as in the bathroom or near heating devices, as this can compromise its effectiveness. Regularly check the expiration date, and for proper disposal of unused or expired tablets, consult a pharmacist or healthcare professional for guidance. Keep the medication securely stored, away from children, to prevent any accidental consumption.

Following are the quick tips for L-Arginine Monohydrochloride 250mg, L-citrulline 75mg Tablet:

• Consult your doctor for the correct dosage and duration, tailored to your specific needs.
• Swallow the tablet whole with a full glass of water to aid in swallowing.
• Maintain a consistent schedule for taking the tablet, preferably at the same time each day.
• Ensure you complete the full course of medication as prescribed by your doctor.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Do not crush or chew the tablet; it is designed to be swallowed whole.
• Inform your doctor if you have any pre-existing medical conditions or are taking other medications.