Erdos (150mg) 20 Capsules

Eplerenone is a selective aldosterone antagonist, primarily targeting the mineralocorticoid receptor (MR) in various tissues. Its mechanism of action involves blocking the binding of aldosterone to the MR, which is responsible for mediating the effects of aldosterone in the body. By competitively inhibiting aldosterone's action, eplerenone reduces sodium reabsorption and potassium excretion in the distal nephron of the kidneys, leading to increased sodium and water excretion, and decreased potassium excretion. This results in a reduction of blood pressure and alleviation of symptoms associated with conditions like hypertension and heart failure. Moreover, eplerenone's selectivity for the MR minimizes its impact on other steroid hormone receptors, contributing to a more targeted therapeutic effect.

Eplerenone 150mg

Mineralocorticoid receptor antagonist.

Capsule

The following are the uses of Eplerenone 150mg Capsule:

• Used for treating high blood pressure, especially when other medications have not been effective.
• Used to manage hypertension and improve heart health.
• Used to reduce the risk of heart complications after a heart attack.
• Used in the treatment of heart failure, helping to improve symptoms and reduce hospitalization.
• Used to regulate blood pressure and manage fluid retention.
• Used to treat hyperaldosteronism, a condition where the body produces too much aldosterone.
• Used to enhance the effectiveness of other blood pressure medications.
• Used to improve overall cardiovascular health and quality of life in patients with heart-related issues.

In the case of an overdose of Eplerenone 150mg Capsules, prompt medical attention is necessary. Symptoms may include dizziness, fatigue, and gastrointestinal issues. Seek emergency help if you experience severe symptoms such as fainting, irregular heartbeat, or difficulty breathing. Medical professionals can provide appropriate treatment, including monitoring vital signs and administering supportive care to manage the overdose effectively. It is crucial to act quickly and seek assistance.

In the case of a missed dose of Eplerenone 150mg Capsule, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to restart the medication or adjust the dosage accordingly. It is generally recommended to take the missed dose within a 12-hour window from the time it was originally scheduled.

To take Eplerenone 150mg Capsule, swallow the capsule whole with a full glass of water, preferably at the same time each day, as directed by your healthcare professional, and ensure you complete the full course of medication as prescribed.

Following are the conditions or circumstances when Eplerenone 150mg Capsule should not be taken:

• Must not be taken by individuals with a known allergy or hypersensitivity to Eplerenone or other related medications.
• Contraindicated in patients with severe kidney disease or those with a creatinine clearance below a certain level (as determined by the prescribing physician).
• Not suitable for patients with high potassium levels (hyperkalemia) in their blood.
• Should not be used in individuals with a certain type of kidney disease called 'Diabetic Nephropathy' who are not adequately responsive to usual antihypertensive therapy.
• Contraindicated during pregnancy as it may cause harm to the unborn baby.

The side effects of Eplerenone 150mg Capsule may include:

• Increased potassium levels in the blood (hyperkalemia)
• Dizziness
• Fatigue
• Nausea and vomiting
• Diarrhea
• Abdominal pain
• High blood pressure (hypertension)
• Increased urination

Following are the precautions and warnings for Eplerenone 150mg Capsule:

• This medication is not recommended for individuals with severe kidney disease or those with type 2 diabetes and moderate kidney disease. Regular kidney function monitoring is necessary.
• Patients with mild to moderate liver disease should exercise caution and may require dosage adjustments. Eplerenone is not suitable for those with severe liver disease.
• Elderly patients may be more sensitive to the effects of Eplerenone, so caution is advised, especially when starting treatment.
• Potassium levels should be monitored regularly, and caution should be exercised in patients with conditions that may increase potassium levels, such as kidney disease, severe heart failure, or those taking potassium supplements.
• Blood pressure should be monitored regularly during treatment, and any significant changes should be reported to the healthcare provider.
• This medication may cause dizziness or lightheadedness, especially when standing up. Elderly patients should be cautious to avoid falls.
• Patients should not stop taking Eplerenone without consulting their healthcare provider, as sudden discontinuation may lead to a worsening of symptoms.
• Eplerenone may affect blood sugar levels; patients with diabetes should monitor their blood sugar regularly.

Following are the drug interactions for Eplerenone 150mg Capsule:

• Concomitant use with angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs) may increase the risk of hyperkalemia, requiring close monitoring of potassium levels.
• The effect of Eplerenone may be reduced when used with potassium-sparing diuretics, leading to decreased efficacy.
• Potassium supplements or potassium-containing salt substitutes can cause significant increases in serum potassium, requiring careful monitoring.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) may decrease the antihypertensive effect of Eplerenone and increase the risk of renal dysfunction.
• Rifampin, a strong CYP3A4 inducer, can reduce the effectiveness of Eplerenone by increasing its metabolism.
• Ketoconazole, a potent CYP3A4 inhibitor, can lead to increased plasma concentrations of Eplerenone, potentially requiring dose adjustments.
• Fluconazole, another CYP3A4 inhibitor, may also increase Eplerenone levels, necessitating close monitoring and dose modification if needed.
• Grapefruit juice, a known inhibitor of CYP3A4, should be avoided as it can increase the plasma concentrations of Eplerenone.

Following are the food interactions for Eplerenone 150mg Capsule:

• Avoid excessive consumption of potassium-rich foods like bananas, oranges, spinach, and tomatoes. High potassium levels can occur when combined with the medication.
• Grapefruit juice should be used cautiously as it can increase the blood levels of Eplerenone, potentially leading to increased side effects.
• Salt substitutes or low-sodium milk should be checked for potassium content as Eplerenone can increase potassium levels.
• Alcohol may not directly interact, but it's best to avoid excessive drinking as it can affect blood pressure and kidney function.
• A balanced diet is recommended, focusing on low-sodium and moderate potassium intake.
• Avoid licorice as it can decrease the effectiveness of Eplerenone by increasing aldosterone levels.
• Always consult a healthcare professional for personalized advice regarding diet and medication adjustments.

Eplerenone 150mg Capsules should be stored in a cool and dry place, preferably at room temperature, away from direct sunlight and moisture. It is crucial to keep the capsules in their original packaging, ensuring the container is tightly sealed to maintain its integrity. Avoid storing them in bathrooms or kitchens, as heat and humidity can degrade the medication. Always check the expiration date, and never use the capsules past this date. When disposing of unused or expired capsules, do not flush them or throw them into the trash. Instead, consult your local pharmacist or healthcare provider for guidance on proper disposal methods to ensure environmental safety. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Eplerenone 150mg Capsule:

• Always take the medicine as directed by your doctor; do not adjust the dosage without medical advice.
• Swallow the capsule whole with a full glass of water, preferably at the same time each day.
• It can be taken with or without food, but taking it with food can prevent stomach upset.
• Avoid potassium supplements or potassium-rich foods without medical advice.
• Regular blood tests may be required to monitor your potassium levels.
• Inform your doctor about all medications you are taking to avoid potential interactions.
• Store the capsules in a cool, dry place, away from direct sunlight and moisture.