Erdos (175mg/5ml) 100ml Suspension

Eplerenone 175mg, when administered as a syrup or suspension, acts as a selective aldosterone receptor antagonist. Its primary mechanism of action involves blocking the binding of aldosterone to its receptors in the distal nephron of the kidneys. By doing so, eplerenone inhibits the effects of aldosterone, which include sodium reabsorption and potassium excretion. This action promotes the excretion of sodium and water, while reducing potassium loss, thereby helping to lower blood pressure and regulate fluid balance in the body. Specifically, eplerenone blocks the genomic effects of aldosterone, such as the upregulation of sodium channels and sodium-potassium pumps, leading to increased sodium and water excretion in the urine.

Erdosteine

Mineralocorticoid receptor antagonist

Suspension

The following are the uses of Eplerenone 175mg Syrup/Suspension:

• Used for treating high blood pressure, especially in patients with heart disease or after a heart attack.
• Used for managing heart failure, helping to improve symptoms and reduce hospital admissions.
• Used to improve heart function and reduce the risk of sudden cardiac death in heart failure patients.
• Used to treat fluid retention and swelling (edema) caused by various conditions.
• Used as an add-on therapy to standard heart failure treatments to enhance effectiveness.
• Used to reduce the risk of cardiovascular events and mortality in certain patient populations.
• Used to improve overall heart health and quality of life in specific cardiac conditions.

In the case of an overdose of Eplerenone 175mg Syrup/Suspension, prompt medical attention is necessary. Symptoms may include dizziness, fainting, and low blood pressure. The severity of the overdose can vary based on the amount ingested and individual factors. Treatment may involve monitoring vital signs, providing supportive care, and potentially administering medications to counteract the effects of the overdose. It is crucial to seek medical assistance immediately if an overdose is suspected.

In the case of a missed dose of Eplerenone 175mg Syrup/Suspension, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Never double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. It is crucial to maintain consistency when taking this medication.

To administer Eplerenone 175mg Syrup/Suspension, shake the bottle well, measure the prescribed dose using an oral syringe or measuring cup, and take it orally once daily, following the dosage instructions provided by your healthcare professional, which may be taken with or without food.

Following are the conditions/situations when Eplerenone 175mg Syrup/Suspension should not be used:

• Should not be used in patients with a known allergy or hypersensitivity to eplerenone or any of its ingredients.
• Contraindicated in individuals with severe kidney disease or those on dialysis.
• Not recommended for patients with high potassium levels (hyperkalemia) in their blood.
• Should not be used in individuals with significant liver impairment.
• Contraindicated during pregnancy as it may cause harm to the developing fetus.
• Not suitable for breastfeeding mothers as it may pass into breast milk.
• Avoid use in patients with uncontrolled diabetes as it may increase the risk of hyperkalemia.
• Should not be used in children and adolescents under 18 years of age due to insufficient data on safety and efficacy.
• Avoid in patients with a history of Addison's disease (adrenal insufficiency).

The side effects of Eplerenone 175mg Syrup/Suspension may include:

• Dizziness
• Fatigue or weakness
• Nausea and vomiting
• Diarrhea
• High potassium levels (hyperkalemia)
• Headache
• Increased urination
• Skin rash or itching

Following are the precautions and warnings for Eplerenone 175mg Syrup/Suspension:

• This medication is contraindicated in patients with a known hypersensitivity or severe allergic reaction to eplerenone or other related compounds.
• Patients with kidney disease or impairment should be closely monitored as dosage adjustments may be necessary.
• Eplerenone can cause an increase in potassium levels, hence regular monitoring of potassium levels is essential, especially in elderly patients and those with diabetes or kidney problems.
• It may cause dizziness or lightheadedness, so patients should be cautious when performing tasks that require alertness, such as driving or operating heavy machinery.
• The syrup/suspension should be taken with food to minimize gastrointestinal side effects.
• Avoid potassium supplements or potassium-rich foods without medical advice as it may lead to a dangerous increase in potassium levels.
• Inform your doctor about all the medications you are taking, especially non-steroidal anti-inflammatory drugs (NSAIDs) and potassium-sparing diuretics, as they can interact with Eplerenone.
• Consult your healthcare provider if you have a history of liver disease or any other medical conditions before taking this medication.

Following are the drug interactions for Eplerenone 175mg Syrup/Suspension:

• Eplerenone may interact with potassium-sparing diuretics, such as spironolactone or triamterene, increasing the risk of hyperkalemia (high potassium levels).
• Concomitant use with angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs) can also lead to hyperkalemia. Close monitoring of potassium levels is necessary.
• Avoid the use of NSAIDs (e.g., ibuprofen, naproxen) as they may reduce the antihypertensive effect of eplerenone and increase the risk of kidney problems.
• The blood pressure-lowering effect of eplerenone may be reduced when used with certain medications like rifampin, which can induce liver enzymes.
• Eplerenone can increase the blood levels of digoxin, requiring careful monitoring of digoxin levels and potential dosage adjustments.
• It may also interact with cyclosporine, increasing the risk of kidney dysfunction and hyperkalemia.
• Caution is advised when combining eplerenone with other medications that affect electrolyte balance, as it may lead to electrolyte disturbances.

Following are the food interactions for Eplerenone 175mg Syrup/Suspension:

• Avoid excessive consumption of potassium-rich foods like bananas, oranges, spinach, and tomatoes, as Eplerenone can increase potassium levels in the body, leading to potential complications.
• Limit the intake of salt substitutes or low-sodium salts that contain potassium chloride, as these can also contribute to elevated potassium levels.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Eplerenone, potentially increasing its blood levels.
• Alcohol may not directly interact with Eplerenone, but it can contribute to dehydration, which can exacerbate the risk of electrolyte imbalances.
• Avoid high-fat meals as they may affect the absorption of Eplerenone, potentially reducing its effectiveness.
• Maintain a balanced diet and stay well-hydrated to support overall health while taking this medication.
• Always consult your healthcare provider for personalized advice regarding dietary restrictions and interactions with Eplerenone.

Eplerenone 175mg Syrup/Suspension should be stored in a secure location, preferably a locked medicine cabinet, at room temperature, avoiding exposure to direct sunlight, heat, or moisture. It is crucial to keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. When disposing of unused or expired syrup, it is recommended to avoid pouring it down the drain or flushing it; instead, consult your pharmacist or healthcare professional for guidance on safe disposal methods to minimize environmental impact. Always ensure that medications are stored away from children's reach to prevent accidental consumption. Regularly check the expiration date, and do not use the medication if it has expired, as its effectiveness and safety may be compromised.

Following are the quick tips for Eplerenone 175mg Syrup/Suspension:

• Consult your doctor before use, especially if you have kidney problems or are pregnant/breastfeeding.
• Take the prescribed dosage; do not adjust it without medical advice.
• Take the syrup as directed by your doctor or pharmacist.
• Measure the dose accurately using the provided measuring device.
• You can take the syrup with or without food, but be consistent with your choice.
• Avoid grapefruit juice and alcohol as they may interact with the medication.
• Store the syrup at room temperature, away from direct sunlight and moisture.