Ertuvia (7.5/500mg) 14 Tablets

Metformin 500mg and Ertugliflozin 500mg combination therapy works synergistically to manage blood sugar levels. Metformin primarily acts by suppressing glucose production in the liver, enhancing insulin sensitivity in peripheral tissues, and inhibiting glucose absorption in the intestines. On the other hand, Ertugliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, blocks the reabsorption of glucose in the kidneys, promoting the excretion of glucose in urine, thereby lowering blood glucose levels. This dual mechanism effectively reduces hyperglycemia and improves glycemic control in patients with type 2 diabetes.

SGLT2 inhibitor, Biguanide.

Tablet

The following are the uses of Metformin 500mg, Ertugliflozin 500mg Tablet:

• Used for controlling blood sugar levels in type 2 diabetes.
• Used to improve insulin sensitivity and reduce glucose production in the liver.
• Used to lower the risk of cardiovascular events in diabetic patients.
• Used to manage weight and promote weight loss.
• Used to enhance glycemic control and reduce A1C levels.
• Used to treat insulin resistance and support pancreatic function.
• Used to lower blood pressure and improve cardiovascular health.
• Used for long-term management of diabetes and associated complications.

In the case of an overdose of Metformin 500mg and Ertugliflozin 500mg Tablets, the patient may experience symptoms such as nausea, vomiting, abdominal pain, and dizziness. In more severe cases, lactic acidosis, a serious condition, can occur. It is important to seek medical advice promptly, as treatment may involve managing symptoms and providing supportive care. Timely intervention can help prevent potential complications, and medical professionals should be contacted for guidance and monitoring.

In the case of a missed dose of Metformin 500mg, take it as soon as you remember, but skip it if it's almost time for your next dose. You can resume your regular dosing schedule with the next dose. For Ertugliflozin 500mg Tablet, if you miss a dose, take it as soon as you remember, but avoid taking two doses close together. You may take the missed dose if there is enough time left before your next scheduled dose. It is important to maintain a consistent dosing schedule for both medications.

To take the Metformin 500mg and Ertugliflozin 500mg Tablet, swallow one tablet whole with a full glass of water, preferably during a meal or as directed by your healthcare professional, once daily at the same time each day.

Following are the conditions or situations when Metformin 500mg and Ertugliflozin 500mg Tablet should not be taken:

• Avoid if you have a history of severe kidney problems or are currently undergoing dialysis treatment.
• Not suitable for individuals with a known allergy to Metformin, Ertugliflozin, or any other sulfonylurea or sulfonamide-based medications.
• Should not be used if you have diabetic ketoacidosis, a serious condition caused by high blood sugar levels.
• Contraindicated during pregnancy or if you are planning to become pregnant, as it may cause harm to the unborn baby.
• Avoid if you have a history of severe liver problems or active liver disease.
• Not recommended for individuals with a history of a serious allergic reaction to any other SGLT2 inhibitor medications.
• Should not be used if you are breastfeeding, as it may pass into breast milk and harm the baby.
• Avoid if you have a history of a type of diabetic eye problem called diabetic macular edema.

The side effects of Metformin 500mg, Ertugliflozin 500mg Tablet may include:

• Nausea and vomiting
• Diarrhea
• Stomach pain or discomfort
• Metallic taste in the mouth
• Increased urination
• Dizziness or lightheadedness
• Genital fungal infections
• Hypoglycemia (low blood sugar) when combined with insulin or other antidiabetic medications

Following are the precautions and warnings for Metformin 500mg, Ertugliflozin 500mg Tablet:

• This medication should not be initiated in patients with type 1 diabetes or diabetic ketoacidosis, and should be discontinued if these conditions occur.
• Patients with renal impairment or a history of kidney problems should be closely monitored, as dosage adjustments may be necessary.
• Liver function should be assessed before starting treatment and monitored regularly, especially in patients with a history of liver disease.
• Patients should be advised to discontinue the medication and seek medical attention if they experience any signs of lactic acidosis, such as unusual fatigue, dizziness, or severe gastrointestinal symptoms.
• Metformin may cause vitamin B12 deficiency with long-term use, so regular monitoring is recommended.
• Elderly patients may be more susceptible to the hypoglycemic effects of this medication, and dosage adjustments might be required.
• It is important to maintain adequate fluid intake while taking this medication to reduce the risk of dehydration and kidney-related adverse effects.
• Patients should be educated about the risk of hypoglycemia, and advised to carry glucose tablets or a sugary snack in case of low blood sugar.

Following are the drug interactions for Metformin 500mg and Ertugliflozin 500mg Tablet:

• Metformin may interact with contrast dyes used in certain medical imaging procedures, increasing the risk of kidney damage. Temporary discontinuation of Metformin may be recommended before such procedures.
• Alcohol consumption can increase the risk of lactic acidosis when taking Metformin. It is advisable to limit or avoid alcohol while on this medication.
• Ertugliflozin may interact with diuretics (water pills), leading to increased diuretic effects and potential dehydration.
• Drugs that affect kidney function can alter the elimination of Ertugliflozin, potentially requiring dose adjustments.
• Certain medications like rifampin, which induce liver enzymes, may reduce the effectiveness of Ertugliflozin.
• Ertugliflozin may increase the risk of hypoglycemia when used with insulin or other antidiabetic medications. Blood sugar monitoring is essential.
• NSAIDs (e.g., ibuprofen) may reduce the blood pressure-lowering effect of Ertugliflozin.

Following are the food interactions for Metformin 500mg, Ertugliflozin 500mg Tablet:

• Alcohol intake should be limited or avoided as it can increase the risk of lactic acidosis, a rare but serious side effect of Metformin.
• Grapefruit and grapefruit juice should be avoided as they may increase the blood levels of Ertugliflozin, potentially leading to increased side effects.
• Avoid high-sugar foods and beverages as Ertugliflozin can cause a decrease in blood sugar levels, and excessive sugar intake may counteract its effects.
• A balanced diet with consistent carbohydrate intake is recommended to maintain stable blood sugar levels while on this medication.
• Avoid high-potassium foods like bananas, oranges, and tomatoes in excess, as Ertugliflozin can increase potassium levels in the blood.
• Consuming a high-fiber diet can help reduce the gastrointestinal side effects associated with Metformin.
• Avoid high-fat meals as they can delay the absorption of Ertugliflozin, affecting its effectiveness.

Metformin 500mg, Ertugliflozin 500mg tablets should be stored in a cool and dry place, preferably at room temperature, away from direct exposure to sunlight and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial to keep this medication out of children's reach to prevent accidental ingestion. When disposing of unused or expired tablets, do not flush them or pour them down the drain. Instead, consult your pharmacist or local waste management guidelines for safe disposal practices to minimize environmental impact. Regularly check the expiration date on the packaging, and never use the medication past its expiry.

Following are the quick tips for Metformin 500mg and Ertugliflozin 500mg Tablet:

• Always take the medication as directed by your doctor; do not adjust the dosage without medical advice.
• Take the tablet with a full glass of water, preferably with a meal or as advised by your doctor.
• Maintain a consistent schedule for taking the medication to ensure its effectiveness.
• Do not break, crush, or chew the tablet; swallow it whole for proper absorption.
• Inform your doctor if you have any kidney or liver problems before taking these medications.
• Regularly monitor your blood sugar levels as instructed by your healthcare provider.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.