Ertuvia-S (5/100mg) 14 Tablets

Diabetes is a condition that affects the metabolism of glucose, or sugar, in the body. There are several medications that are typically prescribed to patients with diabetes, two of those are ertugliflozin and sitagliptin. Ertugliflozin is a member of the SGLT2 inhibitors class of drugs. These drugs work by blocking the enzyme SGLT2, which is responsible for helping your kidneys reabsorb glucose from your urine. By blocking this enzyme, ertugliflozin increases the excretion of glucose through urine, which in turn helps to lower blood sugar levels. It is usually recommended for use in adults with type 2 diabetes, along with diet and exercise, or in combination with other anti-diabetic medications. Sitagliptin falls under the dipeptidyl peptidase-4 (DPP-4) inhibitors class of medications. These drugs work by blocking the enzyme DPP-4, which regulates hormones that influence insulin secretion. One of these hormones is glucagon-like peptide 1 (GLP-1), which stimulates insulin secretion. By inhibiting the DPP-4 enzyme, sitagliptin increases the concentration of GLP-1 hormones, which in turn helps to stimulate insulin secretion only when blood sugar levels are high, thus helping to lower blood sugar levels. This medication is typically recommended for adults with type 2 diabetes who do not achieve their target blood sugar levels through diet and exercise alone, or who are unable to take certain other glucose-lowering medications.

Ertugliflozin:

Unveiling its multifaceted uses and transformative applications as follows:

• Lowering blood sugar levels in adults with type 2 diabetes mellitus
• Used alongside a healthy diet and exercise to improve blood sugar control
• Can be used with other diabetes medications
• May be used with or without insulin
• Reduces the risk of worsening diabetic kidney disease

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• The recommended dose for treatment of type 2 diabetes is Ertugliflozin 5mg and Sitagliptin 100mg
• The dose should be adjusted based on the response and tolerability of the drug under a physician's supervision

Overdose symptoms of Ertugliflozin 5mg and Sitagliptin 100mg may include low blood sugar levels, nausea, vomiting, diarrhea, and abdominal pain. These symptoms require immediate medical intervention. It is recommended to induce vomiting or perform a gastric lavage, followed by the administration of glucose or sugary fluids to restore normal blood sugar levels. Oxygen supply should be facilitated, and vital signs should be monitored until the symptoms subside. If the symptoms are severe or prolonged, it is advised to administer intravenous glucose, analgesics, and antinausea medications. Additionally, educate the patient on safe drug practices and proper storage to prevent future overdose incidents.

If you happen to miss a dose of ertugliflozin 5mg and sitagliptin 100mg, take it as soon as possible. However, if it is almost time for your scheduled dose, skip the missed dose and proceed to take your regular dose as advised. It is imperative not to take a double dose. If you have any doubts or concerns about what to do after missing a dose, contact your doctor or pharmacist for further guidance. It is vital to continue taking this medication as directed, even if you feel well, to prevent any sudden blood sugar rise or adverse symptoms. Maintaining a healthy diet, exercising regularly, and monitoring your blood sugar levels regularly, as per the prescribed method, will ensure effective management of your diabetes and overall well-being.

Before starting your medication regimen of Ertugliflozin and Sitagliptin, ensure that you understand all the instructions regarding the usage of this medication, and follow them accordingly. These instructions are general and may not apply to your specific medical situation. Therefore, it is important to communicate with your doctor extensively about your medical history, any other medications you may be taking, and any other concerns you have before taking Ertugliflozin and Sitagliptin. You should read the Medication Guide offered by your pharmacist or doctor before starting your treatment with Ertugliflozin and Sitagliptin and thereafter each time you get a refill. If you have queries about the guide, consult with your doctor or pharmacist. The medication is to be taken orally, typically once a day, with or without food, as directed by your doctor. The dosage is personalized based on your medical condition, your body's response to the treatment, and use of certain interacting medications, therefore, it is important to provide your doctor and pharmacist with complete and detailed information about all the medications you are taking. To minimize the risk of hypoglycemia, which is low blood sugar, your doctor will advise that you take a short-acting insulin or a different diabetes medication along with Ertugliflozin and Sitagliptin. Follow the directions carefully, and do not change the dosing schedule or the timing of when you take your insulin or other diabetes medication without the express approval of your doctor. If you are taking any medication to help with nausea, take it as directed by your doctor. This is usually recommended to be taken on the day you start taking Ertugliflozin and Sitagliptin and for 1 to 2 days afterward. If you have any questions or uncertainties about how to take this medication, consult with your doctor or pharmacist. Remember, the steps you need to take before you

Discerning instances where this medication may not be appropriate:

• If you miss a dose, it is important to take it as soon as possible
• If you remember it close to the next scheduled dose, it is recommended to skip the missed dose and resume the regular schedule to avoid doubling up
• It is advised to not take this medication if you have any gastrointestinal diseases or hypoglycemia at times of stress or trauma
• Sitagliptin 100mg is also an anti-diabetic drug that is typically taken once a day, with or without food
• There are no specific times when you should or should not take this medication
• If you miss a dose, take it as soon as possible
• If it is close to the next scheduled dose, skip the missed dose and resume the regular schedule to avoid doubling up
• This medication should not be taken if you have a history of pancreatitis or kidney problems

Unraveling the side effects lurking behind this medications are as follows:

• Stomach pain
• Diarrhoea
• Vomiting
• Headache
• Low blood sugar (hypoglycaemia)
• Upper respiratory tract infection
• Nasopharyngitis (inflammation of the nose and throat)

The warnings and precautions for Sitagliptin and Ertugliflozin are:

• Acute pancreatitis, including severe forms, has been reported with Sitagliptin; if suspected, treatment should be discontinued immediately
• Both drugs may cause hypotension, particularly in individuals with renal impairment, the elderly, or those on diuretics; assess and correct volume status before initiating therapy and monitor patients throughout
• Patients presenting with signs of metabolic acidosis should be evaluated for ketoacidosis; if suspected, therapy should be discontinued and promptly treated
• Acute kidney injury is a risk; monitoring renal function is essential
• Urosepsis and pyelonephritis should be evaluated and treated if symptoms arise
• Risk of lower limb amputation should be considered before starting treatment; monitor for infections or ulcers
• Heart failure has been noted with other DPP-4 inhibitors; weigh risks for patients with heart failure risk factors and monitor for symptoms
• To prevent hypoglycemia, a reduction in insulin or insulin secretagogue doses may be necessary
• Monitor for genital mycotic infections and treat if needed
• Serious hypersensitivity reactions, including anaphylaxis and Stevens-Johnson syndrome, have been reported; discontinue and treat appropriately
• Monitor and manage increased LDL-C levels
• Severe and disabling arthralgia has been reported; consider as a possible cause of joint pain
• Bullous pemphigoid, which may require hospitalization, has been associated; report any development of blisters or erosions and discontinue treatment if suspected

The drug interactions with sitagliptin and ertugliflozin include:

• Other Antidiabetics – Can have additive hypoglycemic effects.
• CYP3A4 Inhibitors (e.g., ketoconazole) – Can increase sitagliptin levels.

For Sitagliptin and Ertugliflozin, food interactions that should be considered are:

• Taking with food may help reduce gastrointestinal discomfort.
• No significant interactions with food.

Ertugliflozin and Sitagliptin are two medications that a doctor can prescribe to patients with type 2 diabetes. It is vital to follow the advice of your physician or pharmacist on how to handle your medication. Always contact them directly if you have any inquiries. In general, it is recommended to store these medications in a cool, dry place away from direct sunlight and sources of heat and moisture. Ensure that the medications are kept in an airtight container. Avoid exposing them to moisture or humidity to prevent them from spoiling or diminishing in effectiveness. Additionally, keep these medications out of the reach of children, pets, or anybody else and never share your medication with others. If you have specific questions or concerns about storing your medication, always consult your healthcare provider, pharmacist, or the manufacturer's instructions for the specific storage requirements of the medication.