Esdom (40/30mg) 14 Capsules

Domperidone, a component of the Esomeprazole Capsule, primarily acts as a dopamine receptor antagonist. It exerts its effects by blocking dopamine receptors in the chemoreceptor trigger zone (CTZ) and the upper gastrointestinal tract. This blockade inhibits dopamine-mediated signaling, leading to increased gastrointestinal motility and reduced nausea and vomiting. Domperidone enhances gastric emptying and promotes the movement of food through the digestive system. In addition, it may increase the tone and amplitude of gastric contractions, further aiding in digestion and reducing symptoms associated with gastrointestinal disorders.

Domperidone, Esomeprazole

Prokinetic, Proton Pump Inhibitor

Capsule

The following are the uses of Domperidone, Esomeprazole Capsule:

• Used for treating gastroesophageal reflux disease (GERD) and associated symptoms like heartburn and acid reflux.
• Used for promoting gastric emptying in people with delayed stomach emptying.
• Used for relieving nausea and vomiting.
• Used for managing gastrointestinal issues related to functional dyspepsia.
• Used for controlling excessive gastric acid secretion.
• Used for providing short-term relief from upper gastrointestinal symptoms.
• Used for supporting digestive health and reducing acid-related discomfort.

In the case of an overdose of Domperidone, symptoms may include confusion, dry mouth, and abnormal heart rhythms. Medical attention should be sought immediately, and treatment may involve supportive care and cardiac monitoring. For Esomeprazole Capsule overdoses, potential effects include blurred vision, dizziness, and a slow heartbeat. Again, seek medical help promptly, as treatment could require hospitalization and close observation. Timely intervention is key to managing these overdose situations effectively.

In the case of a missed dose of Domperidone, it is recommended to take the missed dose as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. For Esomeprazole capsules, if you miss a dose, take it as soon as you remember, but if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing. Do not double the dose to make up for a missed one, and if you frequently miss doses, consider setting reminders to help you stay on track.

To take the Domperidone and Esomeprazole Capsule, swallow the capsule whole with a glass of water, preferably in the morning before food, following the dosage instructions provided by your healthcare professional.

Following are the conditions/situations when Domperidone and Esomeprazole Capsule should not be used:

• Should not be used in individuals with a known allergy to either Domperidone or Esomeprazole or any other similar medications.
• Contraindicated in patients with a history of prolonged QT interval or irregular heart rhythms.
• Not suitable for individuals with severe kidney or liver disease.
• Should be avoided in patients with low levels of magnesium or potassium in their blood.
• Must not be used in patients with gastrointestinal bleeding or obstruction.
• Contraindicated in patients with severe dehydration or those at risk of dehydration.
• Not recommended for individuals with a history of seizures or epilepsy.
• Should not be used in patients with a rare condition known as systemic mastocytosis.
• Contraindicated during breastfeeding as Domperidone can suppress lactation.

The side effects of Domperidone, Esomeprazole Capsule may include:

• Dry mouth
• Headache
• Diarrhea or constipation
• Abdominal pain
• Dizziness
• Skin rashes
• Increased levels of prolactin (a hormone)

Following are the precautions and warnings:

• Domperidone, Esomeprazole Capsule should not be used in patients with a known allergy or hypersensitivity to either domperidone or esomeprazole or any other ingredients in the capsule.
• This medication may cause extrapyramidal symptoms, especially in children and adolescents. It should be used with caution in patients with Parkinson's disease or other conditions affecting the central nervous system.
• Patients with underlying heart conditions, such as a history of heart rhythm problems or heart failure, should use this medication with caution as it may cause QT prolongation.
• Caution is advised in patients with liver or kidney impairment, as dosage adjustments may be necessary.
• Esomeprazole may slightly increase the risk of gastrointestinal infections and bone fractures with prolonged use. Regular monitoring is recommended for long-term users.
• This medication may interfere with the absorption of certain drugs; therefore, it is essential to inform your doctor about all the medications you are currently taking.
• Domperidone may cause prolactin elevation, which can lead to galactorrhea, gynecomastia, and menstrual irregularities. Monitor for these symptoms and consult a healthcare professional if they occur.
• Pregnant and breastfeeding women should consult their doctor before taking this medication as it may affect the unborn child and pass into breast milk.

Following are the drug interactions for Domperidone, Esomeprazole Capsule:

• Concomitant use with other dopamine antagonists (e.g., metoclopramide) may increase the risk of extrapyramidal symptoms.
• Domperidone can prolong the QT interval, so caution is advised when used with other drugs that have this effect, such as certain antiarrhythmics and antipsychotics.
• Esomeprazole may reduce the absorption of drugs that require an acidic environment, such as ketoconazole and atazanavir.
• The absorption of Esomeprazole can be decreased by medications like sucralfate and antacids, so separate administration is recommended.
• It may interact with anticoagulants like warfarin, requiring close monitoring of INR values.
• Drugs metabolized by CYP3A4, such as diazepam and cyclosporine, may have altered levels when used with Esomeprazole.
• Concomitant use with Clopidogrel is not recommended, as Esomeprazole may reduce its antiplatelet effect.

Following are the food interactions for Domperidone, Esomeprazole Capsule:

• Avoid grapefruit and grapefruit juice as they can interfere with the metabolism of Esomeprazole, potentially increasing its levels in the blood and the risk of side effects.
• Limit alcohol consumption as it can increase the risk of gastric issues and reduce the effectiveness of Esomeprazole in treating gastrointestinal conditions.
• High-fat meals can delay the absorption of Esomeprazole, potentially reducing its immediate effectiveness.
• Dairy products, especially milk, may interact with Esomeprazole, forming a complex that reduces its absorption. Consider separating dairy intake from medication by a few hours.
• Foods rich in vitamin K, like leafy greens, can potentially reduce the anticoagulant effect of Esomeprazole when used in combination with such medications.
• Spicy foods should be consumed cautiously as they may exacerbate gastrointestinal symptoms in some individuals taking Esomeprazole.
• No significant food interactions are noted with Domperidone, but it's best to consult a healthcare professional for personalized advice.
• Always adhere to the prescription and consult a healthcare provider for specific dietary recommendations during the medication period.

Domperidone, Esomeprazole Capsules should be stored in a cool, dry place, ideally between 68°F and 77°F (20°C and 25°C), ensuring protection from light and moisture. Keep the capsules in their original container, tightly sealed, to maintain their integrity and effectiveness. It is crucial to avoid exposing the medication to extreme temperatures or storing it in the bathroom, as heat and humidity can degrade the capsules. Always check the expiration date, and never use the capsules past this date. For disposal, do not flush or pour the capsules down the drain; instead, consult a pharmacist or healthcare professional for guidance on safe disposal methods. Keep the medication securely stored, out of the reach of children, to prevent accidental consumption.

Following are the quick tips for Domperidone, Esomeprazole Capsule:

• Take the capsule as directed by your doctor, usually 30 minutes before meals.
• Swallow the capsule whole; do not crush, chew, or open it.
• If you have trouble swallowing, ask your pharmacist about alternative forms.
• Maintain a consistent dosing schedule for best results.
• Store the capsules in a cool, dry place, away from moisture and sunlight.
• Inform your doctor if you experience any unusual movements or muscle stiffness.
• Do not share this medication with others, even with similar symptoms.