Esi Dep (20Mg) 14 Tablets

This drug contains Escitalopram; a potent selective serotonin reuptake inhibitor (SSRI), 5-HT (5-hydroxytryptamine, serotonin) transporter (SERT) mediates the reuptake of 5-HT from the synaptic cleft into the neuron, and inhibition of this uptake is the target of selective serotonin reuptake inhibitors (SSRIs) like Escitalopram. Escitalopram is an active isomer of citalopram, binds to the sodium-dependent serotonin transporter protein (SERT) located in the presynaptic neuron. SERT reuptakes serotonin from the synaptic cleft to the presynaptic neuron. Escitalopram Inactivates SERT, as a result amount of serotonin is increased in the synaptic cleft. Serotonin or 5-hydroxytryptamine (5-HT) are involved in modulating a wide range of human behavioral processes, including mood, perception, memory, appetite, fear, anger, aggression, stress response, addiction, and sexuality. So by establishing normal levels of 5-HT; escitalopram treats; major depressive disorder (MDD), generalized anxiety disorder (GAD), and other psychiatric disorders such as obsessive-compulsive disorder. It has superior efficacy and faster onset compared to other SSRIs.

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Tablet

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Escitalopram is utilized for the following therapeutic indications:

• Treatment of major depressive disorder (MDD)
• Management of generalized anxiety disorder (GAD)
• Support for social anxiety disorder
• Treatment of obsessive-compulsive disorder (OCD)
• Alleviation of panic disorder
• Long-term management of depression-related insomnia
• Reducing symptoms of premenstrual dysphoric disorder (PMDD)

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Dose must be taken according to the doctor’s advice only; doses given below are suggested as supportive literature for better understanding in some areas of requirements. Adult dose: For generalized anxiety disorders; Initial dose: 10mg orally one time a day; increase if necessary after at least 1 week of treatment to 20mg one time a day. Maintenance dose: 10 to 20mg orally one time a day. Maximum dose: 20mg orally one time a day. For depression: Initial dose: 10mg orally one time a day; increase if necessary after at least 1 week of treatment to 20mg one time a day. Maintenance dose: 10 to 20mg orally one time a day. Maximum dose: 20mg orally one time a day. Geriatric (65 years above) dose: For Depression; 10mg orally one time a day. Pediatric Dose: For depression; Initial dose: 10mg orally one time a day; increase if necessary after at least 3 weeks of treatment to 20mg one time a day. Maintenance dose: 10 to 20mg orally one time a day. Maximum dose: 20mg orally one time a day.

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Use of Escitalopram in high doses of up to 600 mg has been found to be associated with reversible symptoms like dizziness, sweating, nausea, vomiting, tremor, and somnolence. Rarely confusion, loss of consciousness, convulsions, coma, sinus tachycardia, cyanosis, hyperventilation and rhabdomyolysis might occur. In such cases following measures should be taken: airway maintenance, gastric lavage, use of activated charcoal, cardiac and vital sign monitoring and general symptomatic and supportive measures. There is no specific antidote for Escitalopram.

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In case you missed any dose, take the next dose as soon as you remember, but don't double your next dose to compensate for the missed one.

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Escitalopram can be taken with or without food. Swallow the tablet with water. Do not chew them.

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It is contraindicated in patients with known hypersensitivity to Escitalopram oxalate, citalopram or any ingredient of the product.

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The side effects reported are; Agitation Restlessness Blurred vision Diarrhea Difficulty in sleeping Drowsiness Dry mouth Fever Difficulties urinating Headache indigestion Nausea Increased or decreased appetite Increased sweating Sexual difficulties like decreased sexual ability or libido & ejaculatory delay Change in taste Tremor Weight changes

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Use in Patients with History of Seizure: Like other antidepressants, Escitalopram should be cautiously used in patients with a history of seizure disorder.

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Grapefruit juice could contribute towards unwanted effects.

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Store below 25°C, at a dry place.

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To monitor organs performance before and with the use of this drug, go for the following tests: For brain; CT-scan.

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