Esilgan (1mg) 20 Tablets

Esilgan (1mg) 20 Tablets

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  • Manufacturer HELIX PHARMACEUTICALS (PVT.) LTD.
  • Generic Name

    Estazolam 1mg

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Estazolam, a medication belonging to the class of benzodiazepines, exerts its therapeutic effects primarily by enhancing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter in the brain. It specifically binds to GABA-A receptors, which are ligand-gated chloride channels. Upon binding, Estazolam modulates the opening frequency of these channels, leading to an increase in chloride ion conductance. This heightened chloride influx hyperpolarizes the neuron, making it more resistant to excitation. As a result, Estazolam induces sedative, hypnotic, anxiolytic, and muscle relaxant effects by reducing the overall excitability of the central nervous system. This mechanism of action is pivotal in its use for the short-term treatment of insomnia, offering patients a more restful and uninterrupted sleep.

  • Ingredients

    Estazolam 1mg

  • Drug Class

    Benzodiazepine sedative.

  • Dosage Form

    Tablet

  • Uses

    The following are the uses of Estazolam 1mg Tablet:

    • Used for treating insomnia, helping individuals fall asleep quickly and improve sleep quality.
    • Used for managing anxiety disorders, providing short-term relief from excessive worry and tension.
    • Used for pre-operative sedation, calming patients and reducing anxiety before surgery.
    • Used for treating sleep disturbances caused by jet lag or shift work.
    • Used for aiding relaxation during medical procedures, ensuring patient comfort.
    • Used for managing acute stress reactions, offering temporary relief from intense stress symptoms.
    • Used for supporting sleep in patients with mental health disorders, promoting rest and recovery.
  • In case of Overdose

    In the case of an overdose of Estazolam 1mg Tablets, individuals may experience symptoms such as severe drowsiness, confusion, impaired coordination, and difficulty in breathing. It is important to seek medical assistance promptly if an overdose is suspected. The severity of the effects can vary depending on the individual's tolerance, with older adults and children being more susceptible to adverse reactions. Quick response and medical intervention are vital to ensure the well-being of the individual and prevent potential complications.

  • Missed Dose

    In the case of a missed dose of Estazolam 1mg Tablet, it is generally advised to skip the missed dose and continue with the next scheduled dose. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss a dose and remember it before bedtime, take the missed dose if there is still enough time for the medication to work effectively. However, if it's already close to the time for your next scheduled dose, it's best to simply wait and take the next dose as planned.

  • How To Use

    To take Estazolam 1mg Tablet, swallow the tablet whole with a glass of water, preferably before bedtime, as directed by your healthcare professional, ensuring you follow the prescribed dosage and duration for optimal effectiveness.

  • When Not to Use

    Following are the conditions or circumstances when Estazolam 1mg Tablet should not be taken:

    • Should not be used in individuals with a known allergy or hypersensitivity to Estazolam or any other benzodiazepines.
    • Contraindicated in patients with severe respiratory issues, such as sleep apnea or acute respiratory failure.
    • Not recommended for individuals with acute narrow-angle glaucoma.
    • Should be avoided in patients with severe liver impairment, as it may lead to prolonged drug effects.
    • Not suitable for individuals with a history of severe depression or suicidal thoughts or actions.
    • Contraindicated during pregnancy, especially in the first and third trimesters, due to potential harm to the fetus.
    • Should not be used in breastfeeding mothers, as it can pass into breast milk and may cause adverse effects in the nursing infant.
    • Not recommended for individuals with a history of drug or substance abuse, as it may lead to dependence and withdrawal symptoms.
    • Should be used with extreme caution in elderly patients, as they may be more sensitive to the side effects and are at higher risk of falls.
  • Side Effects

    The side effects of Estazolam 1mg Tablet may include:

    • Drowsiness or sedation
    • Dizziness
    • Confusion or disorientation
    • Impaired coordination
    • Fatigue or weakness
    • Memory problems or amnesia
    • Slurred speech
    • Difficulty concentrating
  • Precautions & Warnings

    Following are the precautions and warnings for Estazolam 1mg Tablet:

    • Estazolam is a potent medication and should be used with caution in elderly patients, as they may be more sensitive to its effects and are at higher risk of experiencing side effects.
    • This medication can cause dizziness and impaired coordination; patients should avoid driving, operating heavy machinery, or engaging in activities that require mental alertness until they know how the medication affects them.
    • Alcohol consumption should be avoided as it can enhance the sedative effects of Estazolam, leading to increased drowsiness and impaired motor skills.
    • Patients with a history of substance abuse or addiction should be closely monitored, as Estazolam has the potential for dependence and abuse.
    • Estazolam may cause respiratory depression, and caution is advised in patients with pre-existing respiratory diseases or conditions that affect breathing.
    • It should be used with caution in patients with liver or kidney impairment, as dosage adjustments may be necessary.
    • Patients should inform their healthcare provider about all medications they are currently taking to avoid potential drug interactions.
    • Estazolam may cause withdrawal symptoms, especially if abruptly discontinued; dosage reduction should be gradual under medical supervision.
  • Drug Interactions

    Following are the drug interactions for Estazolam 1mg Tablet:

    • Alcohol and other CNS depressants like opioids, antipsychotics, or certain antihistamines can enhance the sedative effects, leading to increased drowsiness and impaired breathing.
    • Estazolam may increase the concentration of other drugs metabolized by the liver's cytochrome P450 enzymes, including some antibiotics and antifungals.
    • Drugs that inhibit the metabolism of estazolam, such as ketoconazole and itraconazole, can lead to increased blood levels of estazolam.
    • Rifampicin and other enzyme inducers may decrease the effectiveness of estazolam by increasing its metabolism.
    • Anticonvulsants like phenytoin and carbamazepine may reduce the therapeutic effects of estazolam.
    • Grapefruit juice can inhibit the metabolism of estazolam, resulting in higher drug levels in the body.
    • Caution is advised when combining estazolam with herbal supplements like St. John's Wort, as it may decrease estazolam's effectiveness.
  • Food Interactions

    Following are the food interactions to be aware of when taking Estazolam 1mg Tablet:

    • Grapefruit and grapefruit juice should be avoided as they may alter the metabolism of Estazolam, potentially leading to increased drug levels in the body and heightened side effects.
    • Alcohol consumption should be minimized or avoided as it can enhance the sedative effects of Estazolam, increasing the risk of dizziness, drowsiness, and impaired coordination.
    • Avoid high-fat meals as they may slow down the absorption of Estazolam, affecting its onset and duration of action.
    • Caffeine-rich foods and beverages like coffee, tea, or energy drinks should be limited as they can counteract the sedative effects of Estazolam, making it less effective.
    • Avoid consuming large amounts of dairy products close to taking Estazolam, as calcium can potentially interact with the medication's absorption.
    • Herbal supplements like St. John's Wort should be used cautiously as they may affect the metabolism of Estazolam, potentially reducing its effectiveness.
    • Always follow the dosing instructions provided by your healthcare professional, and inform them about any dietary habits or supplements you are taking.
  • Storage/Disposal

    Estazolam 1mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or designated storage area, away from direct sunlight, moisture, and heat sources. Keep the tablets in their original container, tightly sealed, to maintain their integrity and effectiveness. It is crucial not to store them in the bathroom due to the potential for humidity and temperature fluctuations. Always check the expiration date, and if the tablets have passed their expiry, do not use them and dispose of them appropriately. Proper disposal is essential; do not flush or pour the medication down the drain. Contact your local pharmacist or healthcare provider for guidance on safe disposal methods to ensure environmental responsibility and prevent unauthorized access. Keep the medication out of children's reach to prevent accidental consumption.

  • Quick Tips, if any

    Following are the quick tips for Estazolam 1mg Tablet:

    • Take the tablet as directed by your doctor, typically before bedtime for sleep disorders.
    • Swallow the tablet whole with a glass of water, do not crush or chew.
    • Avoid alcohol consumption while taking this medication.
    • Inform your doctor if you have any pre-existing medical conditions or allergies.
    • Do not drive or operate heavy machinery until you know how this medication affects you.
    • Store the medication at room temperature, away from moisture and light.
    • Discontinue the medication gradually as directed by your doctor to minimize withdrawal symptoms.

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