Esilgan (2mg) 20 Tablets

Estazolam is a benzodiazepine that primarily exerts its therapeutic effects by enhancing the activity of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system. It binds to specific benzodiazepine receptors, which are part of the GABA-A receptor complex. When Estazolam binds to these receptors, it increases the frequency of chloride channel opening, allowing more chloride ions to enter the neuron. This influx of chloride ions hyperpolarizes the neuron, making it more resistant to excitation and thus reducing neuronal excitability. This mechanism is responsible for the sedative, anxiolytic, and muscle relaxant properties of Estazolam, as it decreases the overall level of arousal and anxiety by slowing down the communication between neurons in the brain.

Estazolam 2mg

Benzodiazepine sedative.

Oral

The following are the uses of Estazolam 2mg Tablet:

• Used for treating insomnia and improving sleep quality.
• Used to help individuals fall asleep faster and stay asleep longer.
• Used in managing sleep disturbances associated with anxiety or stress.
• Used to provide short-term relief for insomnia symptoms.
• Used to regulate sleep patterns and promote a more restful sleep.
• Used to alleviate sleep difficulties caused by jet lag or shift work adjustments.
• Used for enhancing overall sleep efficiency and reducing nighttime awakenings.
• Used as a sedative-hypnotic medication to support sleep in specific medical conditions.

In the case of an overdose of Estazolam 2mg Tablets, individuals may experience severe drowsiness, confusion, and impaired coordination. It can lead to respiratory depression, requiring immediate medical intervention. Symptoms may include difficulty breathing, extreme sedation, and even loss of consciousness. Prompt medical attention is necessary to manage the overdose, which may involve administering a specific antidote and providing supportive care to ensure the individual's safety and well-being.

In the case of a missed dose of Estazolam 2mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare provider for guidance on how to get back on track with your medication regimen safely. It's crucial to follow your doctor's instructions regarding missed doses to ensure the effectiveness of the treatment.

To take Estazolam 2mg Tablet, swallow the tablet whole with a glass of water, preferably before bedtime, following the dosage instructions provided by your healthcare professional, typically used for short-term treatment of insomnia.

Following are the conditions/situations when Estazolam 2mg Tablet should not be used:

• Should not be taken if you are allergic to Estazolam or other benzodiazepines.
• Contraindicated in patients with severe respiratory problems, as it can worsen breathing difficulties.
• Not recommended for individuals with a history of acute narrow-angle glaucoma.
• Avoid using if you have severe liver impairment, as it may lead to serious complications.
• Do not use if you have a known diagnosis of sleep apnea.
• Should not be taken by individuals with a history of severe depression or suicidal thoughts/attempts.
• Contraindicated in patients who have recently consumed alcohol or other central nervous system depressants.
• Not suitable for those with a history of drug abuse or dependence.
• Avoid using if you have myasthenia gravis, as it can exacerbate muscle weakness.

The side effects of Estazolam 2mg Tablet may include:

• Drowsiness or sedation
• Dizziness
• Confusion or disorientation
• Impaired coordination
• Fatigue or weakness
• Memory problems or amnesia
• Slurred speech
• Difficulty concentrating

Following are the precautions and warnings for Estazolam 2mg Tablet:

• This medication is intended for short-term use only, typically 7-10 days, due to the risk of dependence and withdrawal symptoms.
• Patients with a history of substance abuse or addiction should be closely monitored, as Estazolam has the potential for abuse and misuse.
• It may cause impairment the day after use, so patients should avoid activities requiring mental alertness until they know how the medication affects them.
• Elderly patients are more sensitive to the effects of Estazolam and may experience more severe side effects, including confusion, dizziness, and increased risk of falls.
• Estazolam can cause respiratory depression, and caution should be exercised when prescribing it to patients with respiratory conditions or compromised respiratory function.
• It should be used with caution in individuals with a history of depression or suicidal thoughts, as it may worsen these conditions.
• Do not abruptly stop taking Estazolam, as it may lead to withdrawal symptoms; dosage should be gradually reduced under medical supervision.

Following are the drug interactions for Estazolam 2mg Tablet:

• Alcohol and other central nervous system (CNS) depressants (e.g., opioids, benzodiazepines, barbiturates) can increase the sedative effects and may lead to respiratory depression.
• Strong CYP3A4 inhibitors like ketoconazole and itraconazole can significantly increase Estazolam levels, leading to enhanced effects and potential overdose.
• Estazolam may potentiate the effects of other CNS depressants like antidepressants and antipsychotics, requiring careful monitoring.
• It can interact with certain antibiotics like erythromycin, leading to increased Estazolam levels and potential toxicity.
• Grapefruit juice should be avoided as it can inhibit CYP3A4, resulting in higher Estazolam concentrations.
• Caution is advised with drugs that prolong the QT interval, as Estazolam may also affect cardiac conduction.
• Estazolam may decrease the effectiveness of hormonal contraceptives, requiring alternative birth control methods.

Following are the food interactions to be aware of when taking Estazolam 2mg Tablet:

• Avoid consuming alcohol as it can enhance the sedative effects of Estazolam, leading to increased drowsiness and impaired coordination.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of Estazolam, potentially increasing its concentration in the body and prolonging its effects.
• Fatty or high-fat meals may delay the absorption of Estazolam, possibly reducing its effectiveness and delaying the onset of action.
• Caffeine-rich foods and beverages should be limited as they can counteract the sedative effects of Estazolam, making it less effective for inducing sleep.
• Avoid heavy or spicy meals close to bedtime when taking Estazolam, as they may cause discomfort and potentially disrupt sleep.
• Dairy products like milk or yogurt can be consumed with Estazolam, but be cautious as they might slightly alter the absorption rate.
• Generally, it is advisable to take Estazolam on an empty stomach to ensure optimal absorption and rapid onset of action.
• Always consult your healthcare provider for specific dietary recommendations while taking Estazolam to ensure its effectiveness and minimize potential interactions.

Estazolam 2mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, away from direct sunlight, moisture, and extreme temperatures. It is crucial to keep the tablets in their original packaging or a well-sealed container to maintain their integrity and prevent exposure to external elements. When disposing of Estazolam tablets, it is important to follow local guidelines for medication disposal. Do not flush the tablets down the toilet or discard them with regular household waste. Instead, utilize designated medication disposal programs or contact your pharmacist or local waste management authorities for guidance on safe and environmentally friendly disposal practices. Keep the medication out of the reach of children and pets to prevent accidental ingestion, and always exercise caution when handling and storing prescription medications.

Following are the quick tips for Estazolam 2mg Tablet:

• Take the tablet just before bedtime as directed by your doctor.
• Swallow the tablet whole; do not crush or chew it.
• Ensure you have a full 7-8 hours for sleep after taking the medication.
• Avoid alcohol and other sedatives while using this medication.
• Inform your doctor if you have a history of substance abuse or depression.
• Do not drive or operate machinery until you know how this medication affects you.
• Store the medication at room temperature, away from moisture and light.