Esoval (40mg) 14 Tablets

Esomeprazole 40mg tablets work by inhibiting the gastric proton pump, which is responsible for the production of stomach acid. The active ingredient, esomeprazole, specifically targets the H+/K+-ATPase enzyme system, also known as the proton pump, in the parietal cells of the stomach. By binding to this pump, esomeprazole blocks the final step in gastric acid secretion, leading to a significant reduction in the production of stomach acid. This mechanism of action helps to suppress excessive acid secretion, providing relief from conditions such as gastroesophageal reflux disease (GERD) and promoting the healing of erosive esophagitis.

Esomeprazole 40mg

Proton pump inhibitor.

Tablet

The following are the uses of Esomeprazole 40mg Tablet:

• Used for treating Gastroesophageal Reflux Disease (GERD)
• Used to relieve symptoms of heartburn and acid reflux
• Used to heal and prevent stomach and intestinal ulcers
• Used for managing conditions like Zollinger-Ellison Syndrome
• Used to reduce stomach acid production
• Used as a maintenance therapy for healed erosive esophagitis
• Used to improve symptoms of indigestion and persistent cough

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Heartburn and gastroesophageal reflux disease (GERD)- Dosage - 20-40 mg once daily for 4-8 weeks, Duration - 4-8 weeks
• Duodenal Ulcer- Dosage - 40 mg once daily for 4 weeks, or 8 weeks if the ulcer has lasted for over a year, Duration - 4 weeks
• Stomach Ulcer- Dosage • 8 weeks, or 12 weeks if associated with NSAID or COX-2 inhibitor, Duration - 8 weeks
• Zollinger-Ellison Syndrome- Initial Dosage - 60 mg once daily, Recommended Increases - May be increased to 120 mg once daily if needed

In the case of an overdose of Esomeprazole 40mg Tablets, it is important to recognize the signs and symptoms, which may include severe drowsiness, confusion, blurred vision, and an irregular heartbeat. Promptly seek medical assistance and provide healthcare professionals with information about the medication, the number of tablets consumed, and the time of ingestion. Quick action can ensure the best possible outcome and help manage any potential complications from the overdose.

In the case of a missed dose of Esomeprazole 40mg Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to restart the medication or provide specific instructions for catching up on missed doses. It's important to maintain a consistent dosing routine for the medication's effectiveness.

To take Esomeprazole 40mg Tablet, swallow the tablet whole with a glass of water, preferably in the morning before a meal, as directed by your healthcare provider, ensuring you follow the prescribed dosage and duration for optimal effectiveness.

Following are the conditions/situations when Esomeprazole 40mg Tablet should not be used:

• Should not be used in individuals with a known allergy to Esomeprazole or other proton pump inhibitors (PPIs).
• Not recommended for individuals with severe liver impairment, as dosage adjustments may be necessary.
• Contraindicated in patients with a history of hypersensitivity reactions to other PPIs.
• Avoid use if you have low magnesium levels or conditions that may worsen with low magnesium, as long-term use may reduce magnesium levels.
• Not suitable for the treatment of immediate heartburn relief.
• Should not be used in combination with certain medications without medical supervision, as Esomeprazole may interact with them.

The side effects of Esomeprazole 40mg Tablet may include:

• Headache
• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Dizziness
• Skin rash or itching
• Fatigue and weakness
• Dry mouth

Following are the precautions and warnings for Esomeprazole 40mg Tablet:

• Esomeprazole should be used with caution in patients with liver problems as it is primarily metabolized by the liver, and dosage adjustments may be necessary.
• It may cause a decrease in bone mineral density with long-term use, so regular monitoring is recommended, especially in patients with osteoporosis or those at risk.
• This medication can interact with other drugs; patients should inform their doctor about all medications they are taking, especially anticoagulants, diazepam, and phenytoin.
• Patients with poor general health or those taking multiple medications may have an increased risk of developing pneumonia.
• Esomeprazole may cause hypomagnesemia (low magnesium levels); prolonged use may lead to severe health issues. Regular monitoring of magnesium levels is recommended.
• It may interfere with the absorption of certain nutrients and medications, such as Vitamin B12 and iron.
• This medication should be used with caution in elderly patients, as they may be more susceptible to side effects, including hip, wrist, and spine fractures.
• Patients should seek immediate medical attention if they experience symptoms such as rash, throat swelling, or difficulty breathing, as these may indicate a severe allergic reaction.

Following are the drug interactions for Esomeprazole 40mg Tablet:

• Concomitant use with Clopidogrel may reduce the antiplatelet effect of Clopidogrel, potentially affecting its efficacy in preventing cardiovascular events.
• Esomeprazole can decrease the absorption of Ketoconazole, Itraconazole, and Erlotinib, reducing their effectiveness.
• The effectiveness of medications like Atazanavir, Nelfinavir, and Saquinavir may be decreased when taken with Esomeprazole.
• May reduce blood levels of Warfarin, potentially altering its anticoagulant effect, requiring monitoring of INR.
• When used with Digoxin, Esomeprazole may slightly increase Digoxin levels.
• The absorption of certain antibiotics like Ampicillin and Erythromycin may be affected, reducing their effectiveness.
• May interact with Diazepam, potentially affecting its metabolism and increasing sedation.

Following are the food interactions for Esomeprazole 40mg Tablet:

• Avoid consuming grapefruit or grapefruit juice as it can significantly increase the concentration of Esomeprazole in the blood, leading to potential toxicity.
• Alcohol intake is not advised with this medication as it can increase the risk of liver damage and may reduce the effectiveness of the drug.
• Esomeprazole can reduce the absorption of Vitamin B12; long-term use may lead to Vitamin B12 deficiency.
• Foods containing high levels of tyramine, such as aged cheeses, cured meats, and certain types of beer, should be avoided as Esomeprazole can interfere with the breakdown of tyramine, potentially leading to high blood pressure.
• Avoid excessive consumption of caffeine as Esomeprazole may prolong the clearance of caffeine from the body, increasing the risk of caffeine-related side effects.
• High-fat meals can delay the absorption of Esomeprazole, potentially reducing its effectiveness.
• Ensure adequate hydration and maintain a balanced diet, as prolonged use of Esomeprazole may lead to nutritional deficiencies.
• Consult your healthcare provider for specific dietary recommendations based on your medical condition and medication regimen.

Esomeprazole 40mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or similar storage area, at room temperature (below 25°C or 77°F). Protect the tablets from light and moisture by keeping them in their original container with the cap tightly closed. It is crucial to maintain a consistent temperature and avoid exposing the medication to direct sunlight or extreme heat. Always check the expiration date on the packaging, and never use the tablets beyond this date. When disposing of unused or expired tablets, do not flush them down the toilet or throw them into the trash. Instead, consult your pharmacist or local waste management guidelines for safe disposal methods to minimize environmental impact. Keep the medication out of the reach of children and pets to prevent accidental consumption.

Following are the quick tips for Esomeprazole 40mg Tablet:

• Consult your doctor for personalized dosage instructions.
• Swallow the tablet whole, do not crush or chew.
• Take the medication as directed, usually once daily before a meal.
• Ensure a consistent routine by taking it at the same time each day.
• Avoid missing doses; if you miss one, take it as soon as you remember.
• Store the tablets in a cool, dry place, away from sunlight.
• Inform your doctor about all medications you are taking.
• Seek medical advice if symptoms persist or worsen.

Esomeprazole is a proton pump inhibitor (PPI) that is used to treat stomach and duodenal ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome. Proton pump inhibitors work by blocking the pumps in the wall of the stomach that produce acid, thus reducing the amount of acid your stomach makes. It is typically prescribed for short-term use, with 8 weeks being the maximum amount of time a person should take Esomeprazole. While routine lab tests are not normally required for monitoring when taking this drug, it is noted that in some instances, certain tests may be recommended for some patients. Esomeprazole is one of the most widely used PPIs, and while it is generally safe when taken for short periods, there are potential side effects that have been noted. These include vitamin B12 deficiency, magnesium deficiency, and kidney failure. To monitor for these potential side effects, vitamin B12 levels, magnesium levels, and kidney function, respectively, are tested. Vitamin B12 Level: