Espra (40mg) 1 Vial Infusion

Esomeprazole 40mg infusion works by specifically inhibiting the proton pump in the stomach's parietal cells, which are responsible for acid secretion. It achieves this by binding to and blocking the H+/K+-ATPase enzyme system, effectively shutting down the final step of gastric acid production. This mechanism leads to a significant reduction in gastric acid secretion, creating a more alkaline environment in the stomach, which helps to alleviate symptoms associated with excessive acid production and promotes the healing of acid-related damage in the gastrointestinal tract.

Esomeprazole 40mg

Proton pump inhibitor.

Infusion

The following are the uses of Esomeprazole 40mg Infusion:

• Used for treating severe Gastroesophageal Reflux Disease (GERD) where oral medication is not suitable or effective.
• Used to manage acid-related damage in the esophagus, providing quick relief.
• Used in the treatment of peptic ulcers, especially when there's a risk of them becoming severe.
• Effective in managing Zollinger-Ellison Syndrome, reducing stomach acid production.
• Used to prevent and treat stress-induced ulcers in critical care settings.
• Provides rapid acid suppression during medical emergencies like upper GI bleeding.
• Used to prepare the stomach before endoscopic procedures for better visibility.

In the case of an overdose of Esomeprazole 40mg Infusion, it is important to recognize the potential risks. Overdosing may lead to severe side effects such as blurred vision, dizziness, and confusion. Gastrointestinal symptoms like nausea, vomiting, and abdominal pain may also occur. Prompt medical attention is necessary to manage these symptoms effectively and ensure appropriate treatment is provided to address the overdose.

In the case of a missed dose of Esomeprazole 40mg Infusion, it is important to administer the medication as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare professional for guidance on how to adjust your dosing schedule. Always store the medication properly and consult your pharmacist or doctor if you have any concerns.

To administer Esomeprazole 40mg Infusion, mix the contents with the provided solvent, swirl gently to dissolve, and administer the solution intravenously over a period of 10-30 minutes, as directed by your healthcare professional.

Following are the conditions/situations when Esomeprazole 40mg Infusion should not be administered:

• Must not be used in patients with known hypersensitivity or severe allergic reactions to Esomeprazole or other proton pump inhibitors (PPIs).
• Contraindicated in patients with severe liver impairment or significant liver disease, as the metabolism of the drug may be affected.
• Should not be used if there is a history of low magnesium levels (hypomagnesemia) or conditions that may cause low magnesium levels.
• Not recommended for individuals with an inherited condition causing poor metabolism of certain drugs (poor CYP2C19 metabolizers).
• Avoid in patients with a history of osteoporosis or osteopenia, as long-term use may increase the risk of bone fractures.
• Do not administer if there is a known or suspected stomach (gastric) malignancy, as it may mask symptoms and delay diagnosis.
• Contraindicated in patients with acute porphyria, a rare metabolic disorder.

The side effects of Esomeprazole 40mg Infusion may include:

• Headache
• Diarrhea
• Nausea and vomiting
• Abdominal pain
• Dizziness
• Fatigue and weakness
• Skin rashes or itching
• Allergic reactions (e.g., swelling of the face, lips, or throat)

Following are the precautions and warnings for Esomeprazole 40mg Infusion:

• Avoid use if you are allergic to esomeprazole or other proton pump inhibitors (PPIs). Cross-allergies are common with this class of drugs.
• Inform your doctor if you have liver or kidney problems as dosage adjustments may be necessary.
• Long-term use, especially in high doses, may increase the risk of bone fractures. Vitamin D and calcium supplements might be recommended.
• Esomeprazole can interact with other medications; inform your doctor about all the medicines you are currently taking.
• It may cause magnesium deficiency with prolonged use, leading to serious side effects. Regular monitoring is advised.
• Elderly patients may need closer monitoring due to increased susceptibility to side effects.
• If you have any gastrointestinal symptoms such as weight loss, vomiting, or difficulty swallowing, seek medical attention immediately.
• Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Following are the drug interactions for Esomeprazole 40mg Infusion:

• It may reduce the absorption of drugs that require stomach acidity for optimal absorption, such as ketoconazole, atazanavir, and iron salts.
• Concomitant use with clopidogrel may reduce the antiplatelet effect of clopidogrel.
• Esomeprazole can increase plasma concentrations of diazepam, warfarin, and phenytoin, potentially requiring dose adjustments.
• It may decrease the metabolism of drugs metabolized by CYP2C19 and CYP3A4, such as diazepam and cyclosporine, leading to increased drug levels.
• The anti-platelet effect of ticagrelor can be reduced when used with Esomeprazole.
• Drugs that are dependent on gastric pH for activation, like amphetamine salts, may have altered absorption.
• Caution is advised when using Esomeprazole with digoxin, as it may increase digoxin levels.
• It may interfere with the absorption of drugs that require stomach acid for conversion, such as erlotinib.

Following are the food interactions for Esomeprazole 40mg Infusion:

• Avoid consuming grapefruit or grapefruit juice as it may interfere with the metabolism of Esomeprazole, potentially increasing its levels in the body and leading to an increased risk of side effects.
• Alcohol intake should be limited as it can irritate the stomach and may reduce the effectiveness of Esomeprazole in treating acid-related conditions.
• Avoid high-fat meals as they can delay the absorption of Esomeprazole, possibly affecting its rapid onset of action.
• Caffeine-rich foods and beverages such as coffee, tea, and energy drinks should be consumed in moderation as they may stimulate acid production and potentially reduce the medication's efficacy.
• Spicy foods are best avoided or minimized as they can trigger acid reflux and may counteract the therapeutic effects of Esomeprazole.
• Chocolate contains compounds that can relax the lower esophageal sphincter, potentially causing acid reflux, so it's advisable to consume it sparingly while on Esomeprazole treatment.
• Dairy products, especially those high in fat, may contribute to acid reflux symptoms and could interfere with the medication's effectiveness.
• Avoid excessive consumption of sugary foods and beverages as they can promote acid production and potentially exacerbate gastrointestinal issues.

Esomeprazole 40mg Infusion should be stored in a controlled environment, preferably at room temperature (25°C/77°F) in a dry place, away from direct sunlight and moisture. The infusion should be kept in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. It is crucial to adhere to the recommended storage conditions to ensure the medication's effectiveness. When disposing of Esomeprazole infusion, it should not be flushed or poured down the drain; instead, follow local guidelines for pharmaceutical waste disposal or consult a healthcare professional for appropriate methods to ensure environmental safety. Keep the medication securely stored, out of children's reach, to prevent accidental consumption.

Following are the quick tips for Esomeprazole 40mg Infusion:

• Administer the infusion as directed by your healthcare professional for effective acid suppression.
• Ensure the infusion is prepared and administered by trained medical staff.
• Infuse the medication over the recommended time period for optimal results.
• Monitor vital signs during and after the infusion for safety.
• Report any unusual symptoms or side effects to your doctor promptly.
• Store the infusion vials as directed by the manufacturer until use.
• Do not use if the solution appears discolored or contains particles.