Esso-40 (40mg) 1 Vial Injection

Esomeprazole is a proton pump inhibitor (PPI) that works by inhibiting the proton pump (H+/K+ ATPase) in the parietal cells of the stomach. This pump is responsible for the final step in the secretion of gastric acid. By blocking this pump, esomeprazole significantly reduces the production of stomach acid, leading to increased gastric pH. This action helps in the treatment of acid-related conditions, such as gastroesophageal reflux disease (GERD) and peptic ulcers.

Esomeprazole 40mg

proton pump inhibitors (PPIs).

injection

The following are the uses of Esomeprazole 40mg Injection:

• Treatment of gastroesophageal reflux disease (GERD) and erosive esophagitis.
• Management of Zollinger-Ellison syndrome (a condition characterized by excessive stomach acid production).
• Used as part of combination therapy for the eradication of Helicobacter pylori infection in patients with peptic ulcers.
• Short-term treatment of gastric ulcers, particularly after nonsteroidal anti-inflammatory drug (NSAID)-induced ulcers.
• Prevention of gastric ulcers in high-risk patients receiving NSAID therapy.
• Management of conditions related to excessive stomach acid production, such as dyspepsia.

Following are the doses of Esomeprazole 40mg Injection:

• The usual dose for adults with gastroesophageal reflux disease (GERD) or erosive esophagitis is one 40mg injection daily, typically for 10-14 days.
• For patients with Zollinger-Ellison syndrome, the dose may vary, and it is typically administered as a higher dose based on the patient's condition, as prescribed by a healthcare provider.
• If used for other conditions such as Helicobacter pylori eradication, the dose is typically adjusted and used as part of combination therapy.
• Always follow the healthcare provider’s exact instructions regarding the dose and duration of treatment for the specific condition being treated.

In case of an overdose of Esomeprazole 40mg Injection, immediate medical attention should be sought. Overdose may lead to symptoms such as confusion, agitation, blurred vision, rapid heartbeat, or gastrointestinal disturbances like nausea or vomiting. If an overdose occurs, contact a healthcare provider immediately. It is important not to induce vomiting or take any other actions without medical guidance. Rinse the area of application if necessary, and avoid further use until instructed by your healthcare provider.

If you miss a dose of Esomeprazole 40mg Injection, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not administer two doses at the same time to make up for the missed dose, as this could increase the risk of side effects. Always follow the dosing instructions provided by your healthcare provider, and consult them if you are unsure about how to proceed after missing a dose.

To use Esomeprazole 40mg Injection typically, it is administered by a healthcare professional through an intravenous (IV) infusion. Make sure to receive the medication at the prescribed times, and do not adjust the dose or frequency without consulting your doctor. Adherence to the prescribed regimen is essential for optimal treatment effectiveness.

Following are the situations when Esomeprazole 40mg Injection should not be used:

• Should not be used in individuals with a known allergy to Esomeprazole or any of its components.
• Contraindicated in patients with severe liver impairment or cirrhosis.
• Should not be used in combination with certain medications like rilpivirine (used for HIV treatment), due to potential drug interactions.
• Caution is advised in patients with a history of osteoporosis, as long-term use may increase the risk of fractures.

The side effects of Esomeprazole 40mg Injection may include:

• Headache
• Nausea
• Abdominal pain
• Diarrhea
• Flatulence
• Dizziness
• Rash
• Fatigue
• Risk of Clostridium difficile-associated diarrhea with prolonged use
• Low magnesium levels (with long-term use)

Following are the precautions and warnings for Esomeprazole 40mg Injection:

• Should not be used in individuals with a known allergy to Esomeprazole or any of its ingredients.
• Caution is advised in patients with a history of liver disease, as Esomeprazole may affect liver enzymes and liver function.
• Use with caution in patients with kidney issues, as long-term use may impact renal function.
• Prolonged use of Esomeprazole can lead to low magnesium levels, potentially causing muscle spasms, irregular heartbeat, or seizures.
• It is not recommended for use in combination with certain medications like clopidogrel due to reduced effectiveness.
• Pregnant or breastfeeding women should consult a healthcare provider before use to assess the risk-benefit ratio.

Following are the drug interactions for Esomeprazole 40mg Injection:

• Concomitant use with Clopidogrel (a blood thinner) may reduce the effectiveness of clopidogrel, increasing the risk of heart attack or stroke.
• Strong CYP2C19 inhibitors (e.g., fluvoxamine, ticlopidine) may increase esomeprazole levels in the blood, potentially leading to side effects.
• Concurrent use with certain antifungal medications like ketoconazole or itraconazole may reduce the absorption of these drugs, decreasing their effectiveness.
• Esomeprazole may interfere with the absorption of other medications that require an acidic stomach environment for proper absorption, such as iron supplements and certain antiviral drugs.
• Caution should be taken when using esomeprazole alongside drugs like warfarin, as it may increase the risk of bleeding. Always consult a healthcare provider before combining medications.

Following are the food interactions for Esomeprazole 40mg Injection:

• Food may delay the absorption of esomeprazole, but it does not significantly affect its overall effectiveness.
• It is advisable to take esomeprazole on an empty stomach, at least one hour before a meal, for optimal absorption.
• Avoid large amounts of alcohol, as it can increase stomach acid production and counteract the effects of the medication.
• Grapefruit and grapefruit juice should be avoided while taking esomeprazole, as it may increase the blood levels of the drug, potentially leading to side effects.

Esomeprazole 40mg Injection should be stored in a cool, dry place, away from light and moisture. It is essential to keep the medication in its original packaging until ready for use. The injectable form is typically stored in a healthcare setting under proper conditions until administration. Unused or expired medication should not be disposed of in household trash or down the drain. Instead, ask your healthcare provider or pharmacist for guidance on the proper disposal method to ensure it is disposed of safely and in accordance with local regulations. Always check the medication for any signs of damage or contamination before use.

Following are the quick tips for Esomeprazole 40mg Injection:

• Use Esomeprazole as prescribed by your healthcare provider for optimal results.
• If you are receiving the injection in a healthcare setting, ensure the medication is administered by a trained professional.
• Do not self-administer this medication unless directed by your healthcare provider.
• Notify your healthcare provider if you have a history of liver or kidney problems before receiving the injection.
• Make sure to follow the recommended treatment course, even if you feel better, to prevent the recurrence of symptoms.