Etosil (25mg) 2ml, 10 Ampoule Injections

Promethazine HCl 25mg, when administered as an injection, primarily acts as a potent first-generation antihistamine. It competitively blocks H1-receptor sites, alleviating allergic responses. Additionally, it exhibits strong anticholinergic properties, sedative effects, and some local anesthetic action. By antagonizing specific neurotransmitters, it suppresses the chemoreceptor trigger zone and diminishes vestibular stimulation, effectively managing symptoms such as nausea, vomiting, and motion sickness. This mechanism makes Promethazine HCl a valuable medication for various conditions requiring antihistamine and antiemetic intervention.

Antihistamine

injection

The following are the uses of Promethazine HCl 25mg injection:

• Used for controlling severe allergic reactions and anaphylaxis.
• Used for treating motion sickness and preventing nausea/vomiting.
• Used for sedation and as a pre-operative medication.
• Used for short-term treatment of insomnia.
• Used for relieving symptoms of the common cold and upper respiratory tract infections.
• Used for managing post-operative pain and providing sedation in intensive care.
• Used for managing severe morning sickness during pregnancy under medical supervision.
• Used for managing certain symptoms in palliative care, ensuring patient comfort.

In the case of an overdose of Promethazine HCl 25mg injection, it is crucial to act promptly. Symptoms may include severe drowsiness, confusion, rapid heartbeat, and seizures. If you suspect an overdose, seek emergency medical help immediately. Do not delay treatment as prompt intervention can prevent serious complications. It is important to have the medication and its packaging available for reference during medical assessment.

In the case of a missed dose of Promethazine HCl 25mg injection, it is important to administer the medication as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. However, do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is advisable to contact your healthcare provider for specific guidance if you frequently miss doses or are unsure about how to manage missed doses.

To administer the Promethazine HCl 25mg injection, clean the injection site, insert the needle at a 90-degree angle, and slowly inject the prescribed dose, ensuring the entire amount is delivered, then gently remove the needle and apply pressure to the site if needed.

Here are the conditions and situations when Promethazine HCl 25mg injection should not be used:

• Avoid use in patients with known hypersensitivity or severe allergic reactions to promethazine or other phenothiazine derivatives.
• Do not administer if the patient has a history of severe asthma attacks or lower respiratory tract infections.
• Contraindicated in children under 2 years of age due to potential for fatal respiratory depression.
• Should not be used in patients with coma or depressed levels of consciousness.
• Avoid use in patients with bone marrow depression or those receiving medications that suppress the bone marrow.
• Not recommended for patients with severe cardiovascular conditions, such as heart block or severe coronary artery disease.
• Do not use in patients with a history of seizures or conditions that lower the seizure threshold.
• Contraindicated during the last trimester of pregnancy due to potential fetal risk.
• Should not be used in patients with known or suspected pheochromocytoma.
• Avoid use in patients with narrow-angle glaucoma.

The side effects of Promethazine HCl 25mg injection may include:

• Drowsiness or sedation
• Dizziness
• Blurred vision or temporary vision changes
• Dry mouth
• Nausea and vomiting
• Confusion or disorientation
• Skin rashes or itching
• Difficulty urinating

Following are the precautions and warnings:

• Promethazine HCl injection should not be used in patients with known hypersensitivity or severe reactions to promethazine or other phenothiazines.
• Caution is advised for patients with liver or kidney impairment, as dosage adjustments may be necessary.
• Promethazine can cause severe respiratory depression, especially in children and elderly patients; it should be used with extreme caution in these populations.
• This medication may impair mental alertness and physical coordination; patients should avoid driving or operating machinery until the full effects are known.
• Avoid alcohol consumption while using Promethazine HCl as it may enhance the sedative effects.
• Promethazine HCl injection should be used with caution in patients with epilepsy or other seizure disorders as it may lower the seizure threshold.
• Patients with cardiovascular conditions should be closely monitored as Promethazine can cause hypotension and cardiac arrhythmias.
• Not recommended for use in children under 2 years of age due to the potential for fatal respiratory depression.

Following are the drug interactions for Promethazine HCl 25mg injection:

• Alcohol and other central nervous system depressants (e.g., opioids, benzodiazepines) can enhance the sedative effects of Promethazine, leading to increased drowsiness and impaired breathing.
• Monoamine oxidase inhibitors (MAOIs) should be avoided within 14 days of stopping Promethazine to prevent a potentially fatal condition called serotonin syndrome.
• Promethazine may reduce the effectiveness of anticholinergic medications, such as those used in Parkinson's disease treatment.
• It can increase the effects of certain antipsychotics and antihistamines, leading to increased sedation and hypotension.
• Anticonvulsant medications may have their metabolism altered by Promethazine, potentially requiring dosage adjustments.
• The effects of anticoagulants like warfarin may be increased, raising the risk of bleeding.
• Promethazine may lower the seizure threshold, so caution is advised when used with other medications that lower this threshold.

Following are the food interactions for Promethazine HCl 25mg injection:

• Avoid alcohol consumption as it can increase the sedative effects of Promethazine, leading to enhanced drowsiness and dizziness.
• Grapefruit and grapefruit juice should be consumed with caution as they may inhibit the metabolism of Promethazine, potentially increasing its levels in the blood and the risk of side effects.
• Avoid high-fat meals as they can delay the absorption of Promethazine, affecting the onset of its therapeutic effects.
• Caffeine-rich foods and beverages may interact with Promethazine, potentially increasing anxiety and restlessness.
• Promethazine may cause dry mouth, so staying well-hydrated and eating soft, moist foods can help alleviate this side effect.
• Avoid foods with tyramine (aged cheeses, cured meats) as they may interact with Promethazine, leading to increased blood pressure.
• Be cautious with salt intake as Promethazine can cause sodium retention, which may be problematic for those on a low-sodium diet.
• Inform your healthcare provider about your diet to ensure it doesn't interfere with the medication's effectiveness.

Promethazine HCl 25mg Injection should be stored in a controlled environment, preferably between 68°F and 77°F (20°C and 25°C), away from excessive heat and moisture. Protect the injection vials from direct sunlight and store them in their original packaging to maintain sterility. Ensure the vials are sealed tightly to prevent contamination. It is crucial not to freeze the injection as it may affect the medication's potency. When disposing of unused or expired injections, do not throw them into the trash or pour them down the drain. Contact your healthcare provider or pharmacist for guidance on safe disposal practices to protect the environment and prevent misuse. Keep the medication out of children's reach to avoid accidental exposure.

Following are the quick tips for Promethazine HCl 25mg injection:

• Administer the injection under medical supervision and as prescribed.
• Ensure the injection is given intramuscularly or intravenously as directed.
• Do not inject into veins or arteries; follow the prescribed route.
• Check the solution for any discoloration or particles before use.
• Avoid rapid intravenous injection to prevent adverse effects.
• Store the injection at room temperature, away from light.
• Dispose of any unused or expired medication properly.
• Consult your healthcare provider if you have any concerns or experience side effects.