Eudemine (50mg) 100 Tablets

Diazoxide, a 50mg tablet, primarily acts as a potassium channel agonist, specifically targeting ATP-sensitive potassium channels in pancreatic beta cells and vascular smooth muscle cells. By opening these channels, diazoxide causes hyperpolarization of the cell membrane, leading to relaxation of vascular smooth muscle and inhibition of insulin release from beta cells. This mechanism is responsible for its therapeutic effects, particularly in the management of hypertension and hypoglycemia. The activation of potassium channels in vascular smooth muscle cells leads to vasodilation, resulting in reduced peripheral vascular resistance and decreased blood pressure. Simultaneously, the inhibition of insulin secretion helps to counteract hypoglycemic episodes by reducing the uptake of glucose by peripheral tissues.

Diazoxide 50mg

Thiazide diuretic.

Tablet

The following are the uses of Diazoxide 50mg Tablet:

• Used for treating high blood pressure in emergencies when immediate reduction is required.
• Used for managing hypoglycemia caused by insulinoma (pancreatic tumors) or certain medications.
• Used to lower blood pressure in patients with severe hypertension.
• Used to control blood sugar levels in people with hyperinsulinism.
• Used to treat persistent high blood pressure in newborns.
• Used to prevent and manage seizures caused by low blood sugar.
• Used to improve blood flow in the heart's arteries during certain procedures.
• Used as a diagnostic tool for insulinoma by triggering hypoglycemia.

In the case of an overdose of Diazoxide 50mg Tablets, individuals may experience symptoms such as severe dizziness, fainting, or lightheadedness. Other potential effects include nausea, vomiting, and an irregular or rapid heartbeat. It is important to seek medical advice promptly if an overdose is suspected. Medical professionals should be contacted immediately for guidance on appropriate treatment and management, which may include supportive care and monitoring of vital signs to ensure the patient's well-being.

In the case of a missed dose of Diazoxide 50mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you've missed multiple doses, contact your healthcare provider for guidance on how to safely resume your medication without affecting your treatment plan. It is crucial to maintain a consistent medication routine for optimal therapeutic benefits.

To take Diazoxide 50mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, ensuring you do not crush or chew the tablet.

Here are the conditions or situations when Diazoxide 50mg Tablet should not be used:

• Should not be used in patients with known hypersensitivity or allergy to diazoxide or any of its excipients.
• Contraindicated in patients with advanced heart failure or myocardial infarction (heart attack).
• Not recommended for individuals with severe renal (kidney) impairment or active renal disease.
• Should not be used in patients with severe liver disease or cirrhosis.
• Contraindicated during pregnancy as it may cause fetal harm.
• Not suitable for breastfeeding mothers as it can be passed into breast milk.
• Should be avoided in patients with severe respiratory distress or pulmonary edema.
• Not recommended for individuals with a history of adrenal gland tumors.
• Should not be used in patients with active peptic ulcer disease.
• Contraindicated in patients with known or suspected pheochromocytoma (a rare adrenal gland tumor).

The side effects of Diazoxide 50mg Tablet may include:

• Excessive hair growth (hirsutism)
• Nausea and vomiting
• Dizziness
• Weakness or fatigue
• Increased heart rate (tachycardia)
• Fluid retention (edema)
• Low blood pressure (hypotension)
• Electrolyte imbalances

Following are the precautions and warnings for Diazoxide 50mg Tablet:

• This medication is not recommended for patients with known hypersensitivity or allergy to Diazoxide or related compounds.
• Diazoxide can cause significant fluid retention and electrolyte imbalances, so regular monitoring of blood pressure, weight, and electrolyte levels is essential.
• Patients with heart conditions, especially congestive heart failure, should be closely monitored as this drug may worsen these conditions.
• It may cause hyperglycemia, so blood glucose levels should be monitored, especially in diabetic patients.
• Caution is advised in patients with a history of kidney or liver disease, as the drug's effects may be altered.
• Elderly patients may be more susceptible to the hypotensive effects of Diazoxide, requiring careful dose adjustment.
• Diazoxide can cause dizziness and lightheadedness; patients should avoid activities that require alertness until they know how the medication affects them.

Following are the drug interactions for Diazoxide 50mg Tablet:

• Concurrent use with other antihypertensive medications can result in additive hypotensive effects, leading to excessive blood pressure drop.
• Taking Diazoxide with beta-blockers may decrease the effectiveness of both drugs in treating hypertension.
• It may interact with diuretics, particularly thiazide diuretics, potentially reducing their diuretic effect.
• The effectiveness of insulin and oral hypoglycemic agents may be reduced when used with Diazoxide, requiring careful blood glucose monitoring.
• Caution is advised when combining Diazoxide with calcium channel blockers, as it can lead to enhanced vasodilation and hypotension.
• Alcohol consumption while taking Diazoxide may result in increased dizziness and lightheadedness.
• Certain medications that are substrates of CYP450 enzymes may have altered metabolism when used with Diazoxide, potentially affecting their effectiveness.

Following are the food interactions to be aware of when taking Diazoxide 50mg Tablet:

• Avoid consuming grapefruit or grapefruit juice as it can interfere with the metabolism of Diazoxide, potentially leading to increased drug levels in the body.
• Alcohol consumption should be limited or avoided as it may enhance the blood pressure-lowering effect of Diazoxide, causing excessive hypotension.
• High-sodium foods should be consumed in moderation as Diazoxide can increase sodium retention, and excessive intake may counteract the medication's effectiveness in controlling blood pressure.
• Potassium-rich foods like bananas, oranges, and spinach are recommended to maintain electrolyte balance since Diazoxide can cause potassium loss.
• Limit caffeine intake from coffee, tea, or energy drinks as it may counteract the blood pressure-lowering effect of Diazoxide.
• Avoid large, heavy meals as Diazoxide can cause gastrointestinal discomfort; instead, opt for smaller, more frequent meals.
• Stay hydrated by drinking enough water, as Diazoxide can cause dehydration due to increased urination.
• Avoid excessive sugar intake, especially from sugary drinks, as Diazoxide may affect blood sugar levels.

Diazoxide 50mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, away from direct sunlight, moisture, and heat. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to air and humidity. It is crucial not to store them in the bathroom or kitchen, as these areas often have fluctuating temperatures and humidity levels. Always check the expiration date before using the medication, and if expired, dispose of it responsibly. Do not flush the tablets or throw them into the trash; instead, consult a pharmacist or healthcare professional for guidance on safe disposal methods. Ensure that the medication is kept out of children's reach to prevent accidental ingestion, as it should be handled with care.

Following are the quick tips for Diazoxide 50mg Tablet:

• Start with a low dose and gradually increase as directed by your doctor.
• Take the tablet with or without food as advised by your doctor.
• Do not crush, chew, or break the tablet; swallow it whole.
• Inform your doctor if you have heart, kidney, or liver problems before taking this medication.
• Regular blood tests may be required to monitor potassium levels during treatment.
• Avoid alcohol consumption as it may increase the risk of side effects.
• Store the medication at room temperature, away from moisture and direct sunlight.