Evorox (250mg) 10 Tablets

Cefuroxime tablets, a second-generation cephalosporin antibiotic, exert their bactericidal effect by inhibiting cell wall synthesis in susceptible bacteria. The drug specifically targets penicillin-binding proteins (PBPs), which are essential for cross-linking peptidoglycan chains during cell wall formation. By binding to these PBPs, cefuroxime interferes with the final stages of cell wall synthesis, leading to the weakening and eventual rupture of the bacterial cell wall. This disruption ultimately results in bacterial cell lysis and death. The mechanism of action is similar to other beta-lactam antibiotics, where the beta-lactam ring within the cefuroxime molecule plays a crucial role in its antibacterial activity.

Cefuroxime

Cephalosporin antibiotic.

Tablet

The following are the uses of Cefuroxime Tablet:

• Used for treating bacterial infections such as pneumonia, bronchitis, and tonsillitis.
• Used for managing skin and soft tissue infections like cellulitis and impetigo.
• Used for addressing urinary tract infections, including bladder and kidney infections.
• Used for combating respiratory tract infections, especially in the early stages.
• Used for preventing and treating bacterial infections before and after surgery.
• Used for alleviating acute bacterial exacerbations in patients with chronic bronchitis.
• Used for managing certain types of ear and sinus infections.
• Used for treating severe bacterial infections when other antibiotics are not suitable.

In the case of an overdose of Cefuroxime Tablets, it is important to recognize the signs and act promptly. Symptoms may include nausea, vomiting, diarrhea, and abdominal pain. If you suspect an overdose, seek medical advice immediately. Quick action can help prevent potential complications, such as severe gastrointestinal issues or allergic reactions. Prompt medical intervention is key to managing any adverse effects and ensuring the patient's well-being.

In the case of a missed dose of Cefuroxime Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance, as they may recommend adjusting your dosage or provide specific instructions to ensure you receive the full benefits of the medication.

To take Cefuroxime Tablet, swallow the tablet whole with a full glass of water, ensuring you follow the prescribed dosage and timing provided by your healthcare professional, typically taken once or twice a day as directed.

Here are the conditions and situations when Cefuroxime Tablet should not be used:

• Avoid if you have a known allergy to Cefuroxime or any other cephalosporin antibiotics.
• Do not use if you have a history of severe allergic reactions to penicillin, as cross-reactivity may occur.
• Contraindicated in patients with a history of cholestatic jaundice/liver problems associated with Cefuroxime use.
• Should not be used if you have severe kidney disease or are on dialysis, without adjusting the dose.
• Not recommended for individuals with a history of gastrointestinal diseases, especially colitis.
• Avoid in patients with a history of seizures or conditions that increase the risk of seizures.
• Not suitable for neonates, especially premature babies, due to the risk of bilirubin encephalopathy.
• Use with caution and avoid in patients with a history of nutritional disorders, particularly vitamin K deficiency.

The side effects of Cefuroxime Tablet may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Skin rash or itching
• Headache
• Dizziness
• Vaginal yeast infection
• Fatigue

Following are the precautions and warnings for Cefuroxime Tablet:

• Do not use if you are allergic to Cefuroxime or any similar antibiotics, and inform your doctor about any previous allergic reactions.
• Inform your doctor about your medical history, especially if you have kidney or liver disease, as dose adjustments may be necessary.
• This medication may cause dizziness or drowsiness; avoid driving or operating heavy machinery until you know how it affects you.
• Cefuroxime may reduce the effectiveness of hormonal birth control methods, so consider alternative contraception during treatment.
• Alcohol consumption is not recommended while taking Cefuroxime as it may increase the risk of side effects.
• If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking this medication.
• Cefuroxime should be used with caution in elderly patients as they may be more susceptible to side effects.

Following are the drug interactions for Cefuroxime Tablet:

• Probenecid can decrease the renal excretion of cefuroxime, potentially increasing its blood levels and risk of side effects.
• Concurrent use with nephrotoxic drugs (e.g., aminoglycosides, diuretics) may increase the risk of kidney damage.
• Cefuroxime may reduce the effectiveness of oral contraceptives, requiring alternative birth control methods.
• Antacids containing aluminum, magnesium, or calcium can decrease the absorption of cefuroxime, so they should be taken at least 2 hours apart.
• Alcohol may increase the risk of gastrointestinal side effects when taken with cefuroxime.
• Drugs that affect kidney function (e.g., diuretics, ACE inhibitors) may alter the elimination of cefuroxime, requiring dosage adjustments.
• Methotrexate levels may be increased when used with cefuroxime, potentially increasing the risk of methotrexate toxicity.

Following are the food interactions for Cefuroxime Tablet:

• Avoid consuming alcohol during the medication period, as it may increase the risk of stomach irritation and liver-related side effects.
• Cefuroxime can be taken with or without food, but taking it with food may help reduce gastrointestinal side effects like nausea and stomach upset.
• Avoid consuming high-fat meals as they may delay the absorption of Cefuroxime, potentially reducing its effectiveness.
• Grapefruit and grapefruit juice should be avoided as they may interfere with the breakdown of Cefuroxime, leading to higher levels of the drug in the body and increasing the risk of side effects.
• Avoid dairy products like milk, cheese, and yogurt, especially if you have a history of lactose intolerance or milk protein allergy, as they may cause digestive discomfort.
• Caffeinated beverages like coffee and tea may increase stomach acid production, potentially reducing the absorption of Cefuroxime, so it's best to limit their intake.
• Ensure adequate fluid intake, especially water, to maintain hydration and promote the elimination of Cefuroxime and its metabolites from the body.
• Certain foods like cruciferous vegetables (broccoli, cauliflower) and high-fiber foods can affect the absorption of Cefuroxime, so it's best to maintain a balanced diet.

Cefuroxime Tablets should be stored in a cool, dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Keep the tablets in their original container, tightly sealed, to maintain their integrity and protect them from moisture. Avoid exposure to direct sunlight, as it can degrade the medication. It is crucial not to store the tablets in the bathroom or near sinks, as humidity can affect their quality. Always check the expiration date, and do not use the medication if it is expired. For disposal, do not flush the tablets down the toilet or pour them into a drain. Contact your pharmacist or healthcare provider for guidance on safe disposal methods to minimize environmental impact. Keep the medication away from children and pets to prevent accidental consumption.

Following are the quick tips for Cefuroxime Tablet:

• Take the tablet as directed by your doctor, typically twice a day.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Cefuroxime can be taken with or without food, but taking it with food may reduce stomach upset.
• Complete the full prescribed course, even if you feel better, to ensure the infection is completely treated.
• Store the tablets at room temperature, away from moisture and direct sunlight.
• Do not share your medication with others, even if they have similar symptoms.
• Inform your doctor if you have any allergies or medical conditions before starting this medication.