Exforge (5/80mg) 28 Tablets

Amlodipine is a medication that prevents calcium ions from entering into cardiac and smooth muscle cells which relaxation of vascular smooth muscle and decreases blood pressure. Valsartan is a hormone antagonist that prevents the hormone angiotensin from causing vasoconstriction by blocking its ability to bind to its receptors. When combined, amlodipine and valsartan provide relaxation of the blood vessels and decrease blood pressure.

Calcium Channel Blocker, Angiotensin Receptor Blocker

Unveiling its multifaceted uses and transformative applications as follows:

• Treat high blood pressure (hypertension)
• Amlodipine is a calcium channel blocker that helps relax the muscles of your heart and blood vessels
• Valsartan is an angiotensin II receptor blocker (ARB) that helps blood vessels to relax so your blood pressure goes down
• Helps protect your kidneys & lower your risk of kidney problems
• May protect your kidneys against further damage if you have diabetes and kidney problems, especially if you have proteinuria (protein in your urine)
• Lower your risk of stroke
• Valsartan protects against the damage that high blood pressure can cause to your blood vessels and kidneys
• Amlodipine lowers your chances of angina (chest pain)
• May boost your chance of survival after a heart attack
• May lower your risk of dying if you've already had a heart attack
• Helps protect against kidney problems in diabetics
• Valsartan protects kidney function in people with diabetes mellitus therefore it is recommended to use it in combination with other medications to achieve good blood sugar control

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Amlodipine is a calcium channel blocker used to treat hypertension (elevated blood pressure).
• The recommended starting dose is 5 mg once daily.
• Valsartan is an angiotensin II receptor antagonist (sometimes called an ARB) and is used to treat high blood pressure.
• It is also used to decrease the risk of stroke in people who have had a stroke already.
• For adults, the typical starting dose is 80-160 mg by mouth once a day.

An overdose of Amlodipine 5mg and Valsartan 80mg can be dangerous, and it is imperative to seek emergency medical attention. Your doctor or a healthcare provider will be able to decide on the best course of action, depending on your health history and specific circumstances. The treatment will be personalized to you, but may involve monitoring your vital signs, managing your fluid balance, or treating any cardiovascular complications. There are additional treatments that can counteract the effects of an overdose or address symptoms you may be experiencing. Please seek emergency medical assistance if you have overdosed on these medications or are experiencing any adverse side effects.

If you miss a dose of amlodipine 5mg and valsartan 80mg, it is important to take the missed dose as soon as possible. However, if it is almost time for your next dose, it is recommended to skip the missed dose altogether. Do not take a double dose to make up for the missed one, as maintaining a regular dosing schedule is crucial. It is always a good idea to consult a doctor or pharmacist before taking any extra medicine to see if it is suitable for your condition. Remember, it is important to take your medication as directed and at the prescribed time to achieve the best possible results.

Amlodipine and valsartan are both medications that are typically taken once daily, with or without food, and at the same time each day. These drugs work best as part of a holistic treatment plan that includes diet, exercise, and other lifestyle changes, and it's important to disclose all other medications you are taking, including supplements, to your healthcare provider. Their dosages depend on the patient's condition and response to treatment, so it is important to follow your doctor's instructions carefully and not hesitate to ask questions or voice concerns about your prescription.

Discerning instances where this medication may not be appropriate:

• If you are allergic to either of the active ingredients (amlodipine or valsartan) or any of the inactive tablet ingredients.
• If you have certain heart problems such as aortic stenosis or muscular dystrophy.
• If you have liver problems or decreased liver function or an upcoming surgery or procedure in which you will receive anesthesia.
• If you are pregnant, plan to become pregnant, or are breastfeeding.
• If you have had a serious allergic reaction to similar medications in the past.
• It is important to provide your doctor with accurate and detailed information about your health history and update them on any

Unraveling the side effects lurking behind this medications are as follows:

• Dizziness
• Headache
• Tiredness
• Abdominal pain
• Constipation
• Nausea

Amlodipine Rare side effects

• Allergic reactions such as hives
• Swelling of the lips, face, throat, and tongue
• Itching
• Difficulty breathing

Valsartan Common side effects

• Dizziness
• Fatigue
• Weakness
• Nausea
• Coughing
• Difficulty breathing
• Swelling of the lips, tongue, and face

Valsartan serious side effects requiring immediate medical attention (rare cases)

• Sudden and rapid weight gain
• Severe headaches
• Unexplained abdominal or leg pain
• Valsartan may cause fetal harm when administered to a pregnant woman.

Here are the essential warnings and precautions for the use of the medication:

• Patients with sodium or volume depletion, idiopathic or hereditary angioedema, biliary obstructive disorders, or primary hyperaldosteronism should use this medication with caution. It should also be used carefully in patients with severe obstructive coronary artery disease, severe congestive heart failure (CHF), recent myocardial infarction (MI), mitral or aortic stenosis, hypertrophic cardiomyopathy with outflow tract obstruction, and diabetes mellitus (DM).
• Special attention is needed for patients undergoing surgery or dialysis.
• The medication should be used cautiously in those with renal conditions, such as chronic kidney disease or unilateral/bilateral renal artery stenosis, as well as in patients with mild to moderate hepatic impairment.
• The safety of the medication during lactation has not been well established, so it should only be used if advised by a healthcare provider.

Drug interactions with Amlodipine , Valsartan combination include:

• NSAIDs (may reduce antihypertensive effect)
• Potassium-sparing diuretics (risk of hyperkalemia)
• Lithium (increased risk of lithium toxicity)
• Rifampin (decreases amlodipine levels)
• CYP3A4 inhibitors (e.g., ketoconazole) (increases amlodipine levels)
• ACE inhibitors (additive hypotensive effects)
• Other antihypertensives (additive hypotensive effects)
• Grapefruit juice (increases amlodipine levels)
• Diuretics (may enhance antihypertensive effects)

The food interactions that should be considered while using Amlodipine and Valsartan are:

• High-sodium foods can reduce the effectiveness of the medication. A low-sodium diet is recommended.
• Avoid potassium-rich foods and excessive potassium supplements.
• Grapefruit juice may increase side effects by affecting the calcium channel blocker component. It’s best to avoid or limit grapefruit juice.
• Alcohol can amplify the medication’s effects, leading to dizziness or fainting. Limiting alcohol is advised.
• High-fat meals have no direct interaction, but a balanced diet supports overall health.

Amlodipine and Valsartan are crucial medications that need to be stored in a specific environment to maintain their efficacy. It is essential to understand that these medications should never be stored in moist or hot places, and should be out of children's reach at all times in a secure location. All forms of these medicines, including liquids, capsules, and tablets, need to be stored at a room temperature between 20°C to 25°C (68°F to 77°F). It is crucial to follow these guidelines to ensure that the medication works effectively. If you have any specific questions or concerns about your medication or its storage, it is important to consult a medical professional for further help.