Exforge HCT (10/320/25mg) 14 Tablets

The combination of Amlodipine, Hydrochlorothiazide, and Valsartan in this tablet exhibits a synergistic effect on blood pressure control. Amlodipine, a calcium channel blocker, inhibits the influx of calcium ions into smooth muscle cells, leading to vasodilation and reduced peripheral resistance. Hydrochlorothiazide, a diuretic, promotes the excretion of sodium and water, which decreases blood volume and reduces blood pressure. Valsartan, an angiotensin II receptor blocker, blocks the binding of angiotensin II to its receptors, resulting in relaxation of blood vessels and decreased vasoconstriction. Together, these mechanisms effectively lower blood pressure by different pathways, providing comprehensive management of hypertension.

Amlodipine 10mg, Hydrochlorothiazide 25mg, Valsartan 320mg

Calcium channel blocker, Diuretic, Angiotensin Receptor Blocker.

Tablet

The following are the uses of Amlodipine 10mg, Hydrochlorothiazide 25mg, valsartan 320mg Tablet:

• Used for treating high blood pressure (hypertension)
• Used to relax blood vessels and improve blood flow
• Used to reduce extra fluid and lower blood pressure
• Used to block the action of certain hormones to lower blood pressure
• Used for angina (chest pain) relief and preventing heart attacks
• Used to improve heart health after a heart attack
• Used for managing hypertension-related kidney disease
• Used to lower the risk of stroke and heart complications

In the case of an overdose of Amlodipine 10mg, Hydrochlorothiazide 25mg, and Valsartan 320mg tablets, individuals may experience symptoms such as dizziness, rapid heartbeat, and a sudden drop in blood pressure. This combination of medications can lead to severe health consequences if taken in excess. It is important to recognize the signs of an overdose, which may include fainting, extreme fatigue, and difficulty breathing. Prompt medical intervention is necessary to manage the potential risks and complications associated with this medication overdose.

In the case of a missed dose of Amlodipine 10mg, it is generally recommended to take the missed dose as soon as you remember, but if it's almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. For Hydrochlorothiazide 25mg, if you miss a dose, take it as soon as you remember, unless it's close to the time for your next dose. Then, skip the missed dose and continue with your regular dosing schedule. In the case of valsartan 320mg, if you miss a dose, take it as soon as you remember, but if it's almost time for your next dose, skip the missed one and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

To take the Amlodipine 10mg, Hydrochlorothiazide 25mg, and Valsartan 320mg tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, as directed by your healthcare provider.

Following are the conditions or situations when Amlodipine 10mg, Hydrochlorothiazide 25mg, and Valsartan 320mg Tablet should not be taken:

• Should not be used if you are allergic to any of the active ingredients (Amlodipine, Hydrochlorothiazide, or Valsartan) or any other similar medications.
• Contraindicated in patients with severe liver disease or impaired liver function.
• Should not be used if you have a history of angioedema (swelling of the face, lips, tongue, or throat) with or without previous ACE inhibitor therapy.
• Not recommended for individuals with severe kidney disease or those with conditions affecting blood electrolytes, such as low potassium or sodium levels.
• Should not be used if you are pregnant or planning to become pregnant, as it can cause harm to the fetus.
• Contraindicated in patients with a history of or current renal artery stenosis (narrowing of the arteries to the kidneys).
• Not suitable for individuals with severe heart failure or aortic stenosis (narrowing of the aortic valve).
• Should not be used if you have a history of diabetic retinopathy (eye disease related to diabetes).

The side effects of Amlodipine 10mg, Hydrochlorothiazide 25mg, and Valsartan 320mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Headache
• Nausea and vomiting
• Increased urination
• Skin rashes or itching
• Swelling of the ankles or feet (peripheral edema)
• Muscle cramps

Following are the precautions and warnings for Amlodipine 10mg, Hydrochlorothiazide 25mg, and Valsartan 320mg Tablet:

• Patients with known allergies to any of the components, including amlodipine, hydrochlorothiazide, or valsartan, should not take this medication.
• It is crucial to monitor blood pressure regularly, especially during the initial stages of treatment, as it may cause a sudden drop in blood pressure.
• Patients with impaired kidney function should exercise caution, as this medication can affect kidney health.
• Electrolyte imbalances may occur, particularly with increased urination; regular monitoring is necessary.
• Diabetic patients should be aware that this medication may alter blood sugar levels.
• Avoid using this medication during pregnancy or breastfeeding without medical advice, as it may have adverse effects on the fetus or infant.
• Inform your doctor if you have any heart, liver, or lung conditions before starting this medication.
• Do not drive or operate heavy machinery if you experience dizziness or fatigue as a side effect.

Following are the potential interactions for Amlodipine 10mg, Hydrochlorothiazide 25mg, and Valsartan 320mg Tablet:

• Concurrent use of Amlodipine and Valsartan may lead to an increased risk of low blood pressure (hypotension). Regular blood pressure monitoring is recommended.
• Hydrochlorothiazide, a diuretic, can increase the risk of electrolyte imbalances, such as low potassium (hypokalemia) or low sodium (hyponatremia). It is important to monitor electrolyte levels during treatment.
• The combination of Valsartan and Hydrochlorothiazide can enhance the antihypertensive effect, which may result in excessive lowering of blood pressure. Caution should be exercised, especially during the initiation of therapy.
• Amlodipine can interact with certain medications, such as strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir), which may increase Amlodipine levels and risk of side effects like swelling or dizziness.
• Combining Hydrochlorothiazide with non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the effectiveness of the diuretic and potentially lead to kidney dysfunction.
• Potassium-sparing diuretics or potassium supplements should be used cautiously with Hydrochlorothiazide due to the increased risk of hyperkalemia (high potassium levels).
• Valsartan, as an angiotensin II receptor blocker (ARB), should not be used concomitantly with other ARBs or angiotensin-converting enzyme (ACE) inhibitors due to the risk of acute kidney injury or hyperkalemia.
• Caution should be used when combining these medications with lithium, as there is an increased risk of lithium toxicity.
• If taken alongside medications that affect the renin-angiotensin-aldosterone system (RAAS), such as aliskiren, the combination could increase the risk of renal impairment, hyperkalemia, and hypotension.
• Alcohol consumption can enhance the blood pressure-lowering effects of these medications and may lead to dizziness or fainting.
• Diuretics like Hydrochlorothiazide can increase blood sugar levels, so blood glucose monitoring is recommended for patients with diabetes.

Following are the food interactions for Amlodipine 10mg, Hydrochlorothiazide 25mg, and Valsartan 320mg Tablet:

• Grapefruit and grapefruit juice should be avoided as they may affect the metabolism of Amlodipine, potentially increasing its blood levels and the risk of side effects.
• Avoid excessive alcohol consumption as it can lower blood pressure further and increase the risk of dizziness and lightheadedness.
• Potassium-rich foods like bananas, oranges, and spinach are beneficial as Hydrochlorothiazide can cause potassium loss.
• Limit sodium (salt) intake to prevent water retention and maintain the effectiveness of the medication.
• Valsartan may cause potassium levels to rise; monitor intake of high-potassium foods like avocados and tomatoes.
• Avoid or limit licorice consumption as it can interfere with the medication's effects on blood pressure.
• Follow a balanced diet as directed by your healthcare provider to manage blood pressure effectively.

Amlodipine 10mg, Hydrochlorothiazide 25mg, and Valsartan 320mg tablets should be stored in a cool, dry place, preferably at room temperature, and protected from light and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to environmental factors. Avoid storing them in bathrooms or near heat sources like ovens or radiators, as temperature fluctuations can impact their effectiveness. Dispose of any unused or expired medication responsibly; do not flush them or throw them into the trash. Consult your pharmacist or healthcare provider for guidance on proper disposal methods. It is crucial to keep these medications out of children's reach to prevent accidental consumption.

Following are the quick tips for Amlodipine 10mg, Hydrochlorothiazide 25mg, and Valsartan 320mg Tablet:

• Always take the medication as directed by your doctor, do not adjust the dosage without medical advice.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Maintain a consistent schedule by taking the tablet at the same time each day.
• It is recommended to take your dose with or after a meal to prevent stomach upset.
• If you miss a dose, take it as soon as you remember, unless it's close to your next dose.
• Avoid drinking alcohol as it may increase side effects.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.