Ezetrol (10mg) 28 Tablets

Ezetrol (10mg) 28 Tablets

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  • Manufacturer MSD Pharmaceuticals (Pvt.) Ltd.
  • Generic Name

    Ezetimibe 10mg

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Ezetimibe, the active ingredient in the 10mg tablet, primarily acts by inhibiting the absorption of cholesterol in the small intestine. Its mechanism of action targets the Niemann-Pick C1-Like 1 (NPC1L1) protein, which plays a crucial role in the intestinal absorption of cholesterol. By binding to NPC1L1, ezetimibe blocks the uptake of cholesterol from the digestive tract, thereby reducing the amount of cholesterol that enters the bloodstream. This inhibition occurs at the brush border of the intestinal epithelium, preventing the transport of cholesterol from the intestinal lumen into the enterocytes. As a result, less cholesterol is available for incorporation into lipoproteins and subsequent transport to the liver, leading to a decrease in circulating low-density lipoprotein cholesterol (LDL-C) levels. This selective mechanism makes ezetimibe an effective adjunctive therapy for managing high cholesterol levels, particularly when used in combination with other lipid-lowering agents.

  • Ingredients

    Ezetimibe 10mg

  • Drug Class

    Statin-adjunct cholesterol absorption inhibitor.

  • Dosage Form

    Tablet

  • Uses

    The following are the uses of Ezetimibe 10mg Tablet:

    • Used for lowering high cholesterol levels in the blood, especially in patients who have difficulty controlling cholesterol through diet and exercise alone.
    • Used for treating heterozygous familial hypercholesterolemia, a genetic disorder causing high cholesterol.
    • Used to reduce the risk of heart disease and stroke by managing cholesterol levels.
    • Used in combination with statins to enhance cholesterol-lowering effects.
    • Used as an alternative for patients who cannot tolerate statins.
    • Used to improve overall lipid profile by reducing total cholesterol and LDL (bad) cholesterol.
    • Used to increase HDL (good) cholesterol levels.
  • In case of Overdose

    In the case of an overdose of Ezetimibe 10mg Tablets, it is important to recognize the signs and symptoms, which may include abdominal pain, diarrhea, and increased liver enzymes. If an overdose is suspected, seek medical advice promptly. Treatment involves supportive care, and healthcare professionals may recommend monitoring liver function and providing appropriate symptomatic relief. It is crucial to take immediate action and not delay seeking professional help to ensure the best possible outcome.

  • Missed Dose

    In the case of a missed dose of Ezetimibe 10mg Tablet, it is generally advised to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is important to maintain consistency with your medication regimen, so try to take the medication at the same time each day to ensure maximum effectiveness. Consult your healthcare provider if you frequently miss doses or have concerns about the timing of your medication.

  • How To Use

    To take Ezetimibe 10mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, as directed by your healthcare provider, typically once daily with or without food.

  • When Not to Use

    Following are the conditions or situations when Ezetimibe 10mg Tablet should not be used:

    • Must not be taken by individuals with a known allergy or hypersensitivity to Ezetimibe or any of its inactive ingredients.
    • Not suitable for patients with moderate to severe liver disease as it may lead to worsening of liver function.
    • Should be avoided in pregnant women unless clearly necessary, as there is limited data on its safety during pregnancy.
    • Should not be used in breastfeeding mothers as Ezetimibe may pass into breast milk and its effects on infants are not well established.
    • Contraindicated in patients with sitosterolemia, a rare inherited lipid disorder, as Ezetimibe can increase the absorption of plant sterols, potentially worsening the condition.
    • Not recommended for individuals with a history of gastrointestinal malabsorption syndromes, as the absorption of Ezetimibe may be affected.
  • Side Effects

    The side effects of Ezetimibe 10mg Tablet may include:

    • Muscle pain
    • Diarrhea
    • Fatigue
    • Joint pain
    • Abdominal pain
    • Allergic reactions (e.g., rash, itching)
    • Elevated liver enzymes
    • In rare cases, it may cause muscle breakdown (rhabdomyolysis) when used with certain other medications.
  • Precautions & Warnings

    Following are the precautions and warnings for Ezetimibe 10mg Tablet:

    • Individuals with a known allergy to Ezetimibe or any of its ingredients should not take this medication.
    • Regular monitoring of liver function is recommended, especially in patients with pre-existing liver conditions.
    • Ezetimibe may increase the risk of gallstones, so patients with a history of gallbladder disease should be closely monitored.
    • Caution is advised when taking this medication with other cholesterol-lowering drugs, as it may increase the risk of muscle-related side effects.
    • Patients with a history of diabetes should have their blood sugar levels monitored regularly, as Ezetimibe may affect glucose control.
    • This medication may not be suitable for individuals with a history of gastrointestinal problems, as it can cause digestive issues.
    • Pregnant and breastfeeding women should consult their doctor before taking Ezetimibe, as its effects during pregnancy and lactation are not fully established.
    • Patients experiencing unexplained muscle pain, weakness, or dark urine should seek immediate medical attention, as these could be signs of rare but serious side effects.
  • Drug Interactions

    Following are the drug interactions for Ezetimibe 10mg Tablet:

    • When taken with statins (e.g., simvastatin, atorvastatin), it can increase the risk of muscle-related side effects, including myopathy and rhabdomyolysis.
    • May interact with cyclosporine, increasing the risk of myopathy and affecting liver function.
    • The absorption of Ezetimibe can be reduced by bile acid sequestrants, such as cholestyramine.
    • Taking Ezetimibe with fibrates (e.g., fenofibrate) may increase the risk of muscle toxicity.
    • It can affect the absorption of fat-soluble vitamins (A, D, E, and K) when used with vitamin supplements containing these vitamins.
    • Rifampin, a strong CYP3A4 inducer, may decrease Ezetimibe plasma concentrations.
    • Antacids containing aluminum or magnesium can reduce the absorption of Ezetimibe, so they should be taken at least 2 hours apart.
    • Some antifungal medications (e.g., ketoconazole) may increase Ezetimibe plasma levels, requiring dose adjustments.
  • Food Interactions

    Following are the food interactions for Ezetimibe 10mg Tablet:

    • Ezetimibe can be taken with or without food, but it is generally recommended to take it at a consistent time each day, preferably during a meal or shortly after.
    • Grapefruit juice should be avoided as it may increase the concentration of Ezetimibe in the blood, potentially leading to an increased risk of side effects.
    • Consuming high-fat meals while taking Ezetimibe can be beneficial as it can enhance the absorption of the medication, ensuring better effectiveness in lowering cholesterol levels.
    • Avoid excessive alcohol consumption as it may increase the risk of liver-related side effects and negatively impact cholesterol levels.
    • There is no significant interaction with dairy products, but a balanced diet is recommended to support overall cardiovascular health.
    • Some herbal supplements, like red yeast rice, may interact with Ezetimibe, so consult your doctor before taking any herbal remedies.
    • Maintain a healthy diet low in saturated fats and cholesterol to support the medication's effectiveness in managing cholesterol levels.
    • Always follow the advice of your healthcare provider regarding dietary recommendations while taking Ezetimibe.
  • Storage/Disposal

    Ezetimibe 10mg tablets should be stored in a cool, dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Keep the tablets in their original container, tightly sealed, to protect them from moisture and light. It is important to store this medication away from heat and direct sunlight as it may affect its potency. Do not store it in the bathroom or kitchen to prevent exposure to moisture and heat. Always check the expiration date, and dispose of any unused or expired tablets by following local guidelines or consulting a pharmacist for advice on safe disposal methods. Keep the medication out of reach of children and pets to prevent accidental ingestion.

  • Quick Tips, if any

    Following are the quick tips for Ezetimibe 10mg Tablet:

    • Consult your doctor before starting the medication for personalized advice.
    • Take the tablet as directed, usually once daily with or without food.
    • Ensure you swallow the tablet whole without crushing or chewing.
    • Maintain consistency by taking your dose at the same time each day.
    • Do not increase or decrease the dosage without medical guidance.
    • Inform your doctor about all medications you are taking to prevent potential interactions.
    • Store the tablets in a cool, dry place, away from direct sunlight and moisture.

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