FalciNil DS (40/240mg) 12 Tablets

Artesunate 240mg Tablet primarily acts by interfering with the parasite's mitochondrial metabolism. It selectively targets the Plasmodium falciparum parasite, one of the primary causes of severe malaria. Artesunate rapidly reacts with ferrous iron to form free radicals and reactive oxygen species within the parasite. These reactive species cause oxidative damage to the parasite's proteins, lipids, and DNA, leading to its destruction. The primary mechanism involves the cleavage of the parasite's hemoglobin, resulting in the formation of free heme and reactive oxygen species, which are toxic to the parasite. This process disrupts the parasite's membrane and leads to its rapid destruction, thus preventing the progression of malaria.

Artesunate 240mg

Antimalarial

Tablet

The following are the uses of Artesunate 240mg Tablet:

• Used for severe malaria treatment, especially in cases of drug-resistant strains.
• Used for reducing malaria parasite load quickly in critical cases.
• Used to manage cerebral malaria complications.
• Used for treating severe malaria in regions with high resistance to other antimalarials.
• Used in combination with other drugs for comprehensive malaria therapy.
• Used for its fast-acting properties to alleviate malaria symptoms rapidly.
• Used in emergency malaria treatment protocols.

In the case of an overdose of Artesunate 240mg Tablets, it is important to recognize the signs and symptoms, which may include gastrointestinal distress, increased heart rate, and potential neurological effects. Immediate medical intervention is necessary to manage the overdose effectively. Treatment may involve supportive care, such as fluid therapy and monitoring vital signs, as well as addressing any specific symptoms that arise. Prompt medical attention is crucial to minimize potential complications and ensure the best possible outcome.

In the case of a missed dose of Artesunate 240mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you miss multiple doses, contact your healthcare provider for advice, as they may recommend adjusting your dosing schedule or provide further instructions to ensure the treatment remains effective. It is essential to adhere to the prescribed regimen for optimal therapeutic benefit.

To take Artesunate 240mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Here are the conditions and situations when Artesunate 240mg Tablet should not be used:

• Should not be used in patients with a known allergy to Artesunate or other artemisinin-based compounds.
• Contraindicated in patients with severe liver disease or liver failure.
• Not recommended for individuals with severe kidney disease or those on dialysis.
• Should not be used as a monotherapy; it must be given in combination with other antimalarial drugs.
• Contraindicated in patients with a history of prolonged QT interval or cardiac arrhythmias.
• Not suitable for individuals with a known glucose-6-phosphate dehydrogenase (G6PD) deficiency.
• Should be avoided in patients with a history of severe gastrointestinal disorders or those currently experiencing severe nausea and vomiting.

The side effects of Artesunate 240mg Tablet may include:

• Nausea and vomiting.
• Temporary hair loss.
• Allergic reactions, such as skin rashes, itching, or hives.
• Temporary decrease in white blood cell count (leukopenia).
• Dizziness or lightheadedness.
• Abnormal liver function tests.
• Diarrhea.
• Fatigue.

Following are the precautions and warnings for Artesunate 240mg Tablet:

• This medication is intended for the treatment of severe malaria and should only be used under medical supervision.
• Artesunate should not be used in patients with a known allergy to the drug or its components.
• Patients with severe liver or kidney disease should use this medication with caution and under close medical monitoring.
• It is crucial to ensure the patient is not allergic to artemisinin derivatives before administration.
• Do not exceed the prescribed dosage, as high doses may lead to prolonged QT interval and cardiac arrhythmias.
• Pregnant and breastfeeding women should only use Artesunate if the potential benefits outweigh the risks, and under the guidance of a healthcare professional.
• This medication may cause dizziness or lightheadedness; patients should be cautious when performing tasks that require alertness.
• Regular monitoring of blood glucose levels is necessary for diabetic patients as Artesunate may affect blood sugar control.

Following are the drug interactions for Artesunate 240mg Tablet:

• Artesunate may interact with other antimalarial drugs like chloroquine or mefloquine, increasing the risk of adverse effects and affecting treatment outcomes.
• Concomitant use with certain antibiotics, such as doxycycline or tetracycline, can reduce the effectiveness of Artesunate.
• Artesunate can enhance the effects of anticoagulant medications, including warfarin, leading to increased bleeding risk.
• Caution is advised when combining Artesunate with drugs that affect the heart's electrical activity, as it may increase the risk of cardiac arrhythmias.
• It may interact with immunosuppressant medications, altering their effectiveness and requiring close monitoring.
• Artesunate can affect the metabolism of certain anticonvulsant drugs, potentially requiring dose adjustments.
• Drug interactions with antiretroviral medications used for HIV treatment are possible, necessitating careful monitoring and dosage adjustments if needed.

Following are the food interactions to be aware of when taking Artesunate 240mg Tablets:

• Artesunate may interact with high-fat meals, leading to increased absorption and potential elevation of drug levels in the body.
• Avoid grapefruit and grapefruit juice as they can affect the metabolism of Artesunate, potentially increasing its concentration in the blood.
• Alcohol consumption is generally not recommended during Artesunate therapy as it may cause liver-related complications and increase the risk of side effects.
• Caffeine-rich foods and beverages should be consumed in moderation as they may interact with Artesunate, potentially affecting its efficacy.
• Dairy products with high-fat content might interfere with Artesunate absorption, so consider spacing out their consumption from taking the medication.
• Avoid excessive amounts of Vitamin K-rich foods like leafy greens, as they may counteract the anticoagulant effects of Artesunate.
• Herbal supplements, especially those affecting blood clotting, should be used cautiously and only under medical supervision while on Artesunate treatment.
• Always consult your healthcare provider for personalized advice on diet and drug interactions to ensure the safe and effective use of Artesunate.

Artesunate 240mg Tablets should be stored in a cool, dry, and dark place, preferably in a medicine cabinet or a designated storage area. Keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain its integrity and protect it from moisture and light. Avoid exposing the tablets to direct sunlight or extreme temperatures, as this can degrade the medication. It is crucial not to store them in the bathroom or kitchen, where humidity and heat can affect their potency. Always check the expiration date, and do not use the tablets if they are past their expiry. Dispose of unused or expired medication responsibly; do not throw it in the trash or flush it down the toilet. Contact your local pharmacist or healthcare provider for guidance on proper disposal methods to ensure environmental safety. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Artesunate 240mg Tablet:

• Take the tablet as directed by your doctor, usually once daily or as prescribed.
• Swallow the tablet whole with a glass of water; do not crush or chew it.
• Artesunate is often given in combination with other antimalarial drugs for best results.
• Complete the full course of medication as prescribed, even if you feel better after a few days.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Inform your doctor if you have any allergies or are taking other medications.
• Seek immediate medical attention if you experience severe side effects like dizziness, fainting, or difficulty breathing.