Farmorubicin CS (50mg/25ml) 1 Vial Injection

Epirubicin HCl, a potent anthracycline antibiotic, exerts its cytotoxic effects primarily through DNA intercalation. Upon entering the cell, epirubicin binds to DNA strands, inserting itself between the base pairs, which interferes with DNA replication and RNA synthesis. This intercalation triggers DNA damage response pathways, leading to cell cycle arrest and apoptosis. Moreover, epirubicin generates reactive oxygen species (ROS) that further contribute to DNA damage, enhancing its cytotoxicity. By targeting rapidly dividing cells and disrupting vital DNA-related processes, epirubicin plays a crucial role in inhibiting tumor growth and proliferation, making it a valuable component of cancer chemotherapy regimens.

Epirubicin HCl 50mg

Anthracycline antibiotic

Injection

The following are the uses of Epirubicin HCl 50mg injection:

• Used for treating breast cancer, often as part of a combination chemotherapy regimen.
• Used for early-stage breast cancer to reduce the risk of recurrence.
• Used for adjuvant therapy after surgery to eliminate any remaining cancer cells.
• Used for neoadjuvant therapy to shrink tumors before surgery, making them operable.
• Used for advanced or metastatic breast cancer to control tumor growth and spread.
• Used for treating soft tissue sarcomas, improving survival rates.
• Used for combination chemotherapy for advanced stomach or gastric cancers.
• Used for improving overall survival and response rates in various cancer types.

In the case of an overdose of Epirubicin HCl 50mg injection, immediate medical intervention is necessary. Symptoms may include severe nausea, vomiting, and a rapid decrease in white blood cell count, leading to an increased risk of infection. Prompt treatment can help manage these symptoms and reduce the potential long-term effects of the overdose. Seek medical care without delay to ensure the best possible outcome.

In the case of a missed dose of Epirubicin HCl 50mg injection, it is important to contact your healthcare provider or pharmacist for guidance. They will provide instructions on whether to administer the missed dose or skip it and continue with the next scheduled dose. It is crucial not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you anticipate a missed dose, it is best to inform your healthcare team in advance to discuss the appropriate course of action.

To administer Epirubicin HCl 50mg injection, reconstitute the vial with the provided diluent, gently swirl to dissolve, and then inject the entire contents intravenously over a period of 3-5 minutes, ensuring proper aseptic technique and following the instructions provided by your healthcare professional.

Following are the conditions when Epirubicin HCl 50mg injection should not be administered:

• Must not be used in patients with a known allergy or hypersensitivity to Epirubicin or any other anthracycline medications.
• Contraindicated in patients with severe liver impairment or those with a high risk of liver toxicity.
• Not suitable for individuals with severe heart disease, recent heart attacks, or those with a low ejection fraction.
• Should be avoided in patients with severe infections or low white blood cell counts, as it can further suppress the bone marrow.
• Not recommended for pregnant women, as it can cause harm to the fetus.
• Contraindicated in breastfeeding mothers, as it can pass into breast milk and harm the baby.
• Should not be used in patients with a known history of severe bleeding disorders.
• Must be used with caution and may be contraindicated in patients with a history of radiation therapy to the chest.

The potential side effects of Epirubicin HCl 50mg injection may include:

• Nausea and vomiting
• Hair loss (alopecia)
• Mouth sores
• Diarrhea
• Fatigue and weakness
• Skin reactions, such as rash or itching
• Decreased appetite
• Increased risk of infection due to low white blood cell counts

Following are the precautions and warnings for Epirubicin HCl 50mg injection:

• This medication is a potent cancer chemotherapy drug and should be handled with extreme care by healthcare professionals only.
• Epirubicin HCl can cause severe myelosuppression; regular blood cell count monitoring is essential during treatment.
• Patients with a history of heart disease, previous chemotherapy, or radiation therapy should be closely monitored for cardiac toxicity.
• It may cause severe skin reactions; immediate medical attention is required if any signs of severe skin reactions occur.
• Avoid contact with the skin and eyes, and ensure proper waste disposal of all materials that come into contact with the drug.
• Epirubicin HCl can cause severe nausea and vomiting; antiemetic medication may be prescribed to manage these side effects.
• It is crucial to avoid pregnancy during and after treatment; effective contraception is advised for both men and women.
• Breastfeeding is not recommended while using this medication as it may pass into breast milk and harm the baby.

Following are the drug interactions for Epirubicin HCl 50mg injection:

• Epirubicin may increase the risk of bleeding when taken with anticoagulants, antiplatelet drugs, and nonsteroidal anti-inflammatory drugs (NSAIDs).
• It can enhance the effects of other cardiotoxic medications, leading to increased cardiotoxicity.
• Concomitant use with other myelosuppressive agents may result in severe myelosuppression.
• Avoid use with live vaccines as Epirubicin may reduce the efficacy of the vaccine.
• Interactions with certain antineoplastic agents can alter the effectiveness and toxicity of Epirubicin.
• Drugs that inhibit or induce CYP3A4 and CYP2D6 enzymes can potentially affect Epirubicin metabolism.
• The risk of cardiac arrhythmias may increase when combined with medications that prolong the QT interval.

Following are the food interactions to consider with Epirubicin HCl 50mg injection:

• Avoid consuming grapefruit and grapefruit juice as they can interfere with the metabolism of the drug, potentially increasing its levels in the blood and leading to higher risks of side effects.
• Alcohol consumption should be minimized or avoided as it can enhance the risk of stomach irritation and increase the chances of liver problems.
• Limit the intake of foods high in salt (sodium) as this medication may cause sodium retention, affecting fluid balance.
• Avoid high-fat meals as they may slow down the absorption of Epirubicin, leading to reduced effectiveness.
• Ensure adequate fluid intake to prevent dehydration, especially if nausea, vomiting, or diarrhea occur as side effects.
• Maintain a balanced diet rich in fruits, vegetables, and whole grains to support overall health during treatment.
• Consult a dietitian or healthcare provider for personalized dietary advice, especially if you have pre-existing dietary restrictions or medical conditions.
• There are no specific food interactions that directly impact the absorption of Epirubicin, but it is crucial to follow the administration guidelines provided by your healthcare team.

Epirubicin HCl 50mg injection should be stored in a secure and controlled environment, specifically in a cool and dry place at room temperature, ensuring protection from light and moisture. It is crucial to keep the injection in its original packaging, tightly sealed to maintain its integrity and prevent contamination. Extreme temperatures should be avoided, so steer clear of storing it in the refrigerator, freezer, or near heat sources. Always adhere to local regulations and guidelines for the safe disposal of unused or expired medication. Do not attempt to dispose of it by flushing or pouring it down the drain; instead, consult your healthcare provider or pharmacist for appropriate disposal methods to ensure environmental safety. Keep the injection out of children's reach to prevent accidental exposure.

Following are the quick tips for Epirubicin HCl 50mg injection:

• Ensure the injection is administered by a trained healthcare professional.
• Confirm your identity and medication details before each injection.
• Inform your doctor about any allergies or medical conditions.
• Report any side effects or unusual symptoms immediately.
• Avoid missing doses; discuss options if you miss a scheduled injection.
• Do not reuse needles or syringes; dispose of them safely.
• Store the medication as directed, away from children and pets.
• Stay hydrated and follow any dietary recommendations provided.