FELDENE 10MG TAB

Piroxicam, a nonsteroidal anti-inflammatory drug (NSAID), exerts its mechanism of action by inhibiting cyclooxygenase (COX) enzymes, primarily COX-1 and COX-2. These enzymes play a crucial role in the synthesis of prostaglandins, which are involved in inflammation, pain, and fever. By blocking the action of COX enzymes, piroxicam reduces the production of prostaglandins, leading to decreased inflammation, pain relief, and reduction of fever. Specifically, piroxicam inhibits the conversion of arachidonic acid to prostaglandin H2, a key step in the prostaglandin synthesis pathway, thereby interrupting the inflammatory cascade and providing therapeutic effects in various conditions where inflammation and pain are present.

Nonsteroidal anti-inflammatory drug (NSAID).

Tablet

The following are the uses of Piroxicam 10mg Tablet:

• Used for reducing inflammation and pain associated with rheumatoid arthritis and osteoarthritis.
• Used for managing acute pain and swelling after surgery or injury.
• Used for treating ankylosing spondylitis, a type of arthritis affecting the spine.
• Used for relieving menstrual pain and discomfort.
• Used for alleviating migraine headaches and reducing their frequency.
• Used for reducing fever and discomfort in conditions like gout.
• Used for providing short-term relief in various musculoskeletal conditions.
• Used for controlling pain and inflammation in certain soft tissue disorders.

Dose may be determined by the doctor. Adjustment may be required for people with renal and hepatic insufficiency

In the case of an overdose of Piroxicam 10mg Tablets, it is important to seek medical assistance promptly. Symptoms of an overdose may include severe stomach pain, nausea, vomiting, and in extreme cases, seizures. Immediate treatment should focus on gastric lavage to remove any unabsorbed medication, and supportive care to manage symptoms. Medical professionals may also administer activated charcoal to help absorb any remaining drug in the gastrointestinal tract. Quick action is crucial to prevent potential complications.

In the case of a missed dose of Piroxicam 10mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication. It is best to establish a routine to help you remember to take your medication at the same time each day.

To take Piroxicam 10mg Tablet, swallow the tablet whole with a full glass of water, preferably with or after a meal, once daily or as directed by your healthcare professional, ensuring you follow the prescribed dosage and duration of treatment.

Following are the conditions/situations when Piroxicam 10mg Tablet should not be taken:

• Avoid if you have a known allergy or hypersensitivity to Piroxicam or other non-steroidal anti-inflammatory drugs (NSAIDs).
• Do not take if you have a history of severe asthma attacks or allergic reactions triggered by aspirin or other NSAIDs.
• Contraindicated in individuals with active or recent gastrointestinal bleeding or perforation.
• Should not be used in patients with severe heart failure or heart disease.
• Not suitable for individuals with severe kidney disease or those at risk of kidney failure.
• Avoid if you have a history of severe liver impairment or liver disease.
• Do not use if you have recently undergone coronary artery bypass graft (CABG) surgery.
• Contraindicated in individuals with a history of stroke, mini-stroke (transient ischemic attack), or blood clots.

The side effects of Piroxicam 10mg Tablet may include:

• Stomach pain or discomfort
• Nausea and vomiting
• Diarrhea or constipation
• Dizziness or lightheadedness
• Headache
• Skin rash or itching
• Increased blood pressure
• Fluid retention and swelling

Following are the precautions and warnings for Piroxicam 10mg Tablet:

• Not recommended for individuals with known allergies to Piroxicam or other NSAIDs.
• Patients with a history of gastrointestinal bleeding, ulcers, or other gastrointestinal disorders should use with caution, as it may increase the risk of gastrointestinal complications.
• Kidney function should be monitored regularly during long-term treatment, as Piroxicam may affect renal function.
• Not recommended for patients with severe heart failure or uncontrolled hypertension.
• May increase the risk of cardiovascular events like heart attack or stroke, especially with long-term use.
• Elderly patients may be more susceptible to side effects; dosage adjustment might be necessary.
• Not recommended during the last trimester of pregnancy and should be used with caution in breastfeeding mothers.

Following are the drug interactions for Piroxicam 10mg Tablet:

• Aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of gastrointestinal bleeding or kidney problems when taken with Piroxicam.
• Lithium levels can be increased by Piroxicam, leading to potential lithium toxicity.
• Piroxicam may reduce the effectiveness of diuretics, particularly loop diuretics, potentially decreasing their diuretic and antihypertensive effects.
• ACE inhibitors, when used with Piroxicam, may have decreased effectiveness in controlling blood pressure.
• Piroxicam can increase the risk of bleeding when taken with anticoagulants like warfarin or heparin.
• When combined with antidiabetic medications, Piroxicam may affect blood sugar control, requiring monitoring and dose adjustments.
• The risk of seizures may increase when Piroxicam is used with certain medications, such as antipsychotics or antidepressants.

Following are the food interactions for Piroxicam 10mg Tablet:

• Alcohol consumption should be avoided as it can increase the risk of gastrointestinal bleeding and liver toxicity.
• Avoid grapefruit and grapefruit juice as they may interfere with the metabolism of Piroxicam, leading to increased drug levels in the body.
• Foods rich in vitamin K, like leafy green vegetables, broccoli, and Brussels sprouts, should be consumed with caution as Piroxicam can reduce the body's ability to clot blood.
• Limit the intake of high-sodium foods, especially if you have high blood pressure, as Piroxicam can cause sodium retention.
• Avoid caffeine or limit its intake, as it may increase the risk of gastrointestinal side effects.
• Consuming fatty or oily meals while taking Piroxicam may delay its absorption, but it does not significantly affect its overall effectiveness.
• There is no specific food restriction, but maintaining a balanced diet is recommended to support overall health during treatment.
• Always follow the advice of your healthcare provider regarding dietary considerations while taking Piroxicam.

Piroxicam 10mg Tablets should be stored in a secure and dry location, preferably in their original container, at room temperature away from direct sunlight, moisture, and heat sources. It is crucial to maintain the medication's integrity by ensuring the container is tightly sealed. Regularly check the expiration date, and if the medication is no longer needed or has expired, proper disposal is essential. Avoid flushing or pouring the medication down the drain; instead, consult a pharmacist or healthcare professional for guidance on safe disposal methods. Keep the tablets out of children's reach to prevent accidental consumption, and always exercise caution when handling and storing medication. This ensures the safety and effectiveness of the treatment.

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Following are the quick tips for Piroxicam 10mg Tablet:

• Take the tablet as directed by your doctor, typically once or twice daily.
• Consume the tablet with a full glass of water to aid in swallowing.
• It can be taken with or without food, but taking it with food may reduce stomach irritation.
• Avoid lying down for at least 10 minutes after taking the tablet to prevent irritation of the esophagus.
• Do not crush or chew the tablet; swallow it whole for proper absorption.
• Inform your doctor if you have any medical conditions or allergies before starting this medication.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.