FERCARI 50MG 10ML INJ

Ferric carboxymaltose is an intravenous iron replacement therapy used to treat iron deficiency anemia. Its mechanism of action involves replenishing iron stores in the body. When administered, the carboxymaltose complex dissociates, releasing ferric iron (Fe³⁺) that binds to transferrin, a protein responsible for transporting iron in the bloodstream. The transferrin-iron complex is then taken up by cells, particularly in the bone marrow, where it is utilized for hemoglobin synthesis and red blood cell production. This process helps increase the number of red blood cells and improves oxygen-carrying capacity, thereby alleviating the symptoms of iron deficiency anemia. The compound's structure ensures a controlled and gradual release of iron, minimizing the risk of free iron-related toxicity.

FERRIC CARBOXYMALTOSE 50MG

Iron replacement therapy

Injection

The following are the uses of FERRIC CARBOXYMALTOSE 50MG Injection:

• Used for treating iron deficiency anemia in adults and children when oral iron therapy is ineffective or cannot be used.
• Used to replenish iron stores in patients with chronic kidney disease undergoing hemodialysis.
• Used to rapidly increase hemoglobin levels and reduce the need for blood transfusions in patients with anemia.
• Used for managing iron deficiency in pregnant women when oral iron supplements are not tolerated or insufficient.
• Used to improve iron levels and reduce fatigue in patients with heavy menstrual bleeding.
• Used to enhance athletic performance and energy levels in athletes with iron deficiency.
• Used to correct iron deficiency and improve overall health in patients with gastrointestinal disorders affecting iron absorption.

In the case of an overdose of Ferric Carboxymaltose 50mg Injection, symptoms may include abdominal pain, nausea, vomiting, diarrhea, and discoloration of the skin or eyes. If an overdose is suspected, immediate medical attention is necessary. The treatment involves managing symptoms and providing supportive care. It is crucial to seek medical help promptly, as overdoses can lead to severe health complications, particularly in vulnerable individuals with underlying conditions.

In the case of a missed dose of FERRIC CARBOXYMALTOSE 50MG Injection, it is important to administer the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Avoid taking extra doses to make up for a missed one. If you miss several doses, contact your healthcare provider for guidance on how to safely resume your treatment.

To administer Ferric Carboxymaltose 50mg Injection, inject the prescribed dose slowly into the muscle or intravenous infusion over a period of 15 minutes, following the instructions provided by your healthcare professional for proper administration and dosage.

Here are the situations when FERRIC CARBOXYMALTOSE 50mg Injection should not be used:

• Do not use if you have a known allergy or hypersensitivity to iron compounds or any of the excipients in the injection.
• Contraindicated in patients with iron overload disorders such as hemochromatosis, hemosiderosis, or hematological disorders like porphyria cutanea tarda.
• Not recommended for individuals with acute or chronic anemia that is not due to iron deficiency, as it may not be effective and could potentially cause harm.
• Should not be used in patients with a history of anaphylactic/anaphylactoid reactions to iron products.
• Avoid in patients with a history of multiple allergies or allergic disorders, as they may be more susceptible to allergic reactions.
• Not suitable for patients with a history of allergic reactions to parenteral iron products.
• Do not use if you have a severe infection or an active inflammatory condition, as it may exacerbate these conditions.
• Contraindicated in patients with a history of poor compliance or inability to follow the recommended administration protocol.

The side effects of FERRIC CARBOXYMALTOSE 50MG Injection may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Dizziness
• Headache
• Skin reactions such as rash or itching
• Joint pain
• Increased heart rate

Following are the precautions and warnings for Ferric Carboxymaltose 50mg Injection:

• This medication is intended for intravenous use only and should be administered by trained healthcare professionals.
• Not recommended for patients with a history of allergic reactions to iron compounds or any of the excipients in the injection.
• Caution is advised in patients with known or suspected iron overload disorders, such as hemochromatosis, as this medication can exacerbate these conditions.
• Regular monitoring of serum ferritin and transferrin saturation levels is recommended during treatment to avoid iron overload.
• Patients with underlying cardiovascular diseases should be closely monitored, as iron therapy may transiently affect blood pressure and heart rate.
• In patients with a history of liver disease, liver function tests should be performed before and during treatment.
• Elderly patients may be more susceptible to the adverse effects of iron therapy, so close monitoring is necessary.
• Ferric Carboxymaltose should be used with caution in patients with active infections or inflammatory conditions, as it may mask the symptoms of these conditions.

Following are the drug interactions for Ferric Carboxymaltose 50mg Injection:

• Antacids containing aluminum, magnesium, or calcium can reduce the absorption of ferric carboxymaltose, so they should not be taken together.
• Iron supplements or other iron-containing products may lead to excessive iron intake, causing iron overload and potential organ damage.
• Deferoxamine, an iron chelator, may reduce the effectiveness of ferric carboxymaltose.
• Concomitant use with parenteral iron preparations is not recommended due to increased risk of adverse reactions.
• Oral antibiotics like tetracyclines can form complexes with iron, reducing the absorption of both substances.
• Bisphosphonates, such as alendronate, may have decreased absorption when used with ferric carboxymaltose.
• Some immunosuppressants, like mycophenolate mofetil, can mask the detection of iron deficiency anemia, requiring close monitoring.

Following are the food interactions for Ferric Carboxymaltose Injection:

• Citrus fruits like oranges, lemons, and grapefruits may interfere with iron absorption and should be avoided shortly before and after taking the injection.
• Tea and coffee contain tannins that can bind to iron, reducing its absorption. Avoid consuming them within an hour of the injection.
• Dairy products such as milk, cheese, and yogurt can decrease iron absorption. Separate them from the time of injection.
• Whole grain products and high-fiber foods may impair iron absorption. Consider spacing out these foods from the injection timing.
• Vitamin C-rich foods like oranges, bell peppers, and broccoli can enhance iron absorption. Consider including these in your diet to improve iron uptake.
• Alcohol can interfere with iron metabolism and may exacerbate gastrointestinal side effects. It's best to avoid alcohol consumption during treatment.
• Avoid taking antacids containing calcium or magnesium within 2 hours of the injection, as they can decrease iron absorption.
• Spacing out meals and snacks from the injection time can ensure optimal iron absorption, as food can sometimes impact its effectiveness.

Ferric Carboxymaltose 50mg Injection should be stored in a controlled environment, preferably at room temperature between 15-25°C (59-77°F), away from direct sunlight and moisture. It is crucial to keep the injection in its original packaging, ensuring the seal remains intact to maintain sterility. Avoid freezing or exposing the injection to extreme heat as it may affect its potency. Once opened, the injection should be used promptly and any unused portion discarded. Do not reuse needles or syringes; dispose of them safely in designated sharps containers. Always follow local guidelines for the proper disposal of medical waste to minimize environmental impact. Keep this medication out of the sight and reach of children to prevent accidental exposure.

Following are the quick tips for Ferric Carboxymaltose Injection:

• This medication is typically administered by a healthcare professional in a clinical setting.
• Ensure you inform your doctor about any allergies or medical conditions before receiving the injection.
• During the injection, you may experience a mild warming sensation or slight discomfort.
• After the injection, maintain the site clean and dry, and avoid strenuous activities for a few hours.
• Report any persistent pain, swelling, or redness at the injection site to your healthcare provider.
• Stay well-hydrated before and after the injection to aid in the medication's effectiveness.
• Follow your doctor's instructions regarding any dietary changes or iron supplements.