Fericit inj 50mg/10ml

Ferric Citrate 50mg Injection works primarily by binding to phosphate in the gastrointestinal tract, forming insoluble ferric phosphate complexes. This mechanism reduces the absorption of phosphate into the bloodstream, leading to decreased serum phosphate levels. The reduced phosphate levels help control hyperphosphatemia, which is often associated with chronic kidney disease. Additionally, the iron present in ferric citrate is absorbed in the intestine, replenishing iron stores and potentially correcting anemia in patients with chronic kidney disease.

Ferric Citrate 50mg

Iron-based phosphate binder

Injection

The following are the uses of Ferric Citrate 50mg Injection:

• Used for treating iron deficiency anemia in patients with chronic kidney disease (CKD) undergoing hemodialysis.
• Used to replenish iron stores and improve hemoglobin levels in CKD patients.
• Used as an alternative to intravenous iron therapy, providing a more convenient route of administration.
• Used to enhance the effectiveness of erythropoietin-stimulating agents (ESAs) in managing anemia.
• Used to reduce the need for blood transfusions in CKD patients by improving iron levels.
• Used to support red blood cell production and alleviate symptoms like fatigue and weakness.
• Used as part of a comprehensive treatment plan for managing anemia in CKD patients.

In the case of an overdose of Ferric Citrate 50mg Injection, symptoms may include gastrointestinal issues such as nausea, vomiting, and diarrhea. It can also lead to elevated iron levels in the body, potentially causing liver damage and other complications. Prompt medical intervention is necessary to manage these symptoms effectively. Healthcare professionals should be contacted immediately to provide appropriate treatment and monitor the patient's condition to prevent further health risks associated with an overdose.

In the case of a missed dose of Ferric Citrate 50mg Injection, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss several doses, contact your healthcare provider for guidance on how to safely resume your medication regimen. It is recommended to set a reminder or keep a medication schedule to help you remember to take your medication on time.

To administer Ferric Citrate 50mg Injection, carefully draw the prescribed dose into a syringe and inject it intravenously, ensuring proper aseptic technique, and follow the recommended dosage and administration guidelines provided by your healthcare professional.

Here are the circumstances in which Ferric Citrate 50mg Injection should not be administered:

• Must not be used in patients with a known allergy to ferric citrate or any of its ingredients.
• Not indicated for patients with iron overload syndromes (e.g., hemochromatosis).
• Avoid use in patients with acute or chronic bleeding until the bleeding is controlled.
• Not recommended for individuals with severe kidney impairment or those on dialysis who are not able to monitor and control iron levels.
• Contraindicated in patients with a history of iron metabolism disorders or porphyria.

The side effects of Ferric Citrate 50mg Injection may include:

• Darkening of stools
• Abdominal pain or discomfort
• Nausea and vomiting
• Diarrhea or constipation
• Dizziness or lightheadedness
• Fatigue and weakness
• Skin discoloration (e.g., orange or brown discoloration)
• Allergic reactions (e.g., rash, itching, swelling)

Following are the precautions and warnings for Ferric Citrate 50mg Injection:

• Patients with known hypersensitivity or allergies to Ferric Citrate or any of its components should not use this medication.
• It is crucial to monitor iron levels regularly during treatment, as excessive iron can lead to iron overload and organ damage.
• Ferric Citrate should be used with caution in patients with a history of kidney disease, as it may affect kidney function.
• This medication may cause gastrointestinal issues like nausea, vomiting, and diarrhea, especially when starting treatment.
• Patients with a history of gastrointestinal disorders should use it with caution and report any severe or persistent symptoms.
• Ferric Citrate may interact with other medications, particularly those affecting iron absorption, so a healthcare professional should be consulted before combining it with other drugs.
• It is essential to maintain adequate hydration during treatment to minimize the risk of kidney-related side effects.
• Pregnant and breastfeeding women should use Ferric Citrate only under medical supervision, as it may impact fetal and infant iron levels.

Following are the drug interactions for Ferric Citrate 50mg Injection:

• Concomitant use with other iron products or iron-containing multivitamins may lead to excessive iron intake, resulting in iron overload and potential toxicity.
• Ferric Citrate can decrease the absorption of levothyroxine, a thyroid medication, so levothyroxine should be taken at least 4 hours before or 4 hours after Ferric Citrate.
• The absorption of certain antibiotics like ciprofloxacin and levofloxacin may be reduced when taken with Ferric Citrate, potentially decreasing their effectiveness.
• Phosphate binders, such as sevelamer or lanthanum carbonate, may bind to Ferric Citrate, reducing its effectiveness in managing phosphate levels.
• Drugs that affect gastric pH, such as proton pump inhibitors (PPIs) or H2 blockers, may alter the absorption of Ferric Citrate, requiring close monitoring.
• Calcium supplements and calcium-rich foods can decrease the absorption of ferric citrate, so they should be taken at different times.
• Ferric Citrate may decrease the absorption of certain medications like bisphosphonates (e.g., alendronate) and tetracycline antibiotics, requiring a 2-hour separation between doses.

Following are the food interactions for Ferric Citrate 50mg Injection:

• Avoid consuming large amounts of dairy products, calcium supplements, or high-calcium foods within 2 hours before or after taking Ferric Citrate, as calcium can decrease iron absorption.
• Limit or avoid alcohol consumption as it may interfere with iron absorption and can increase the risk of stomach irritation and liver-related side effects.
• Certain foods like eggs, spinach, and whole grains contain phytic acid, which can bind to iron and decrease its absorption. Avoid consuming these foods close to the time of medication intake.
• Coffee, tea, and foods high in polyphenols can also reduce iron absorption. It's best to avoid these beverages/foods for at least an hour before and after taking the injection.
• Vitamin C can enhance iron absorption, so consider consuming citrus fruits, bell peppers, or vitamin C supplements to improve iron uptake.
• Avoid eating raw seafood, especially shellfish, as it may contain bacteria that can lead to serious infections, especially in individuals with weakened immune systems.
• Ensure a balanced diet with sufficient protein, as it aids in the utilization of iron and supports overall health.
• Always follow the advice of your healthcare provider regarding dietary restrictions and recommendations during treatment with Ferric Citrate.

Ferric Citrate 50mg Injection should be stored in a controlled environment, preferably in a cool and dry place at room temperature, away from direct sunlight and moisture. The injection should be kept in its original packaging, tightly sealed to maintain its integrity and prevent contamination. Avoid exposing the injection to extreme temperatures, such as hot or freezing conditions, as it may affect its potency. Always check the expiration date before use, and properly dispose of any unused or expired medication. Do not attempt to dispose of it by flushing or pouring it down the drain; instead, follow local guidelines for pharmaceutical waste disposal or consult a healthcare professional for safe disposal methods. Keep the injection out of children's reach to prevent accidental exposure or ingestion.

Following are the quick tips for Ferric Citrate 50mg Injection:

• Administer the injection as directed by your healthcare professional.
• Ensure proper dosage accuracy by double-checking the medication label before use.
• Ferric Citrate should be injected slowly into the vein as instructed.
• Always use a clean, dry syringe for each injection.
• Dispose of used needles and syringes safely in designated sharps containers.
• If you experience any discomfort or pain during injection, inform your healthcare provider.
• Store the injection as directed on the package, away from direct sunlight and moisture.