Fernor SR (6mg) 10 Tablets

Tizanidine 6mg tablets primarily exert their therapeutic effects through selective agonist activity at the α2-adrenergic receptors in the brain and spinal cord. This mechanism leads to a reduction in presynaptic calcium influx, ultimately inhibiting the release of excitatory neurotransmitters, such as glutamate and substance P. By selectively targeting these receptors, tizanidine effectively decreases the facilitation of spinal motor neuron activity, resulting in muscle relaxation and alleviation of spasticity. The α2-adrenergic receptor activity of tizanidine is highly selective, with a greater affinity for the α2-adrenergic receptors compared to other α-adrenergic receptor subtypes, thus contributing to its efficacy in managing spasticity without significantly impacting other physiological processes.

Muscle relaxant

Tablet

The following are the uses of Tizanidine 6mg Tablet:

• Used for treating muscle spasms, especially in conditions like multiple sclerosis and spinal cord injuries.
• Used to relieve muscle stiffness and improve muscle movement.
• Used to manage chronic pain associated with muscle spasms.
• Used to reduce muscle tension and improve overall comfort.
• Used to aid in physical therapy and rehabilitation processes.
• Used for short-term relief, providing temporary relaxation of muscles.
• Used to enhance mobility and daily functioning in patients with muscle spasms.

In the case of an overdose of Tizanidine 6mg Tablets, individuals may experience severe symptoms such as extreme drowsiness, confusion, and a significant drop in blood pressure. It is crucial to recognize the signs of an overdose, which can include difficulty breathing, slowed heart rate, and even loss of consciousness. Promptly seek medical assistance if an overdose is suspected, as timely intervention is vital. Healthcare professionals should be informed about the dosage taken and any other medications being used to ensure appropriate treatment and management of potential complications.

In the case of a missed dose of Tizanidine 6mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your dosing schedule and ensure you're taking the medication correctly. It is advisable to set reminders or alarms to help you remember your medication times.

To take Tizanidine 6mg Tablets, swallow the tablet whole with a full glass of water, following the prescribed dosage instructions provided by your healthcare professional, typically taken up to three times a day or as directed.

Following are the conditions when Tizanidine 6mg Tablet should not be used:

• Avoid using this medication if you have a known allergy to Tizanidine or any other similar medications.
• Do not take this medicine if you have severe liver impairment or liver disease.
• Contraindicated in individuals with severe kidney problems or those on dialysis.
• Should not be used in patients with a history of long QT syndrome or other heart-related conditions.
• Not suitable for individuals with low blood pressure or those taking medications that lower blood pressure.
• Avoid using Tizanidine if you have recently had a heart attack or have unstable chest pain.
• Do not use this medication if you are currently taking certain antidepressants or antifungal medications.
• Contraindicated during pregnancy or while breastfeeding without medical advice.
• Should not be used in patients with a history of liver or kidney transplant.
• Avoid using this medicine if you have a history of alcohol abuse or currently consume large amounts of alcohol.

The side effects of Tizanidine 6mg Tablet may include:

• Dry mouth
• Dizziness
• Fatigue and drowsiness
• Constipation
• Nausea and vomiting
• Muscle weakness
• Increased heart rate (tachycardia)
• Hypotension (low blood pressure)

Here are the precautions and warnings for Tizanidine 6mg Tablet:

• Tizanidine should not be used in patients with known hypersensitivity or allergy to tizanidine or any of its excipients.
• This medication can cause liver damage; regular monitoring of liver function is recommended, especially in patients with pre-existing liver conditions.
• Tizanidine may cause dizziness and drowsiness; patients should avoid driving, operating heavy machinery, or performing tasks requiring mental alertness until they know how the medication affects them.
• It should be used with caution in the elderly, as they may be more susceptible to its side effects.
• Tizanidine can lower blood pressure, so patients with existing low blood pressure should be monitored closely.
• This drug may interact with other medications, including certain antidepressants and CYP1A2 inhibitors, so a doctor should be informed about all current medications.
• Tizanidine should be used with caution in patients with kidney disease, as dosage adjustments may be necessary.
• Do not abruptly stop taking Tizanidine, as it may lead to withdrawal symptoms; consult a healthcare professional for proper tapering instructions.

Following are the drug interactions for Tizanidine 6mg Tablet:

• Concomitant use with other central nervous system (CNS) depressants like opioids, benzodiazepines, or alcohol can lead to enhanced sedation, respiratory depression, and potentially serious adverse effects.
• Tizanidine may increase the plasma concentrations of drugs metabolized by the liver's CYP1A2 enzyme, such as caffeine, theophylline, and carbamazepine, resulting in increased side effects.
• It can interact with fluvoxamine, a CYP1A2 inhibitor, leading to increased tizanidine levels and potential toxicity.
• Rifampin, a CYP1A2 inducer, may decrease the effectiveness of tizanidine by increasing its metabolism.
• Medications that affect blood pressure, such as ACE inhibitors or beta-blockers, may have additive effects when used with tizanidine.
• Antacids containing magnesium or aluminum can reduce the absorption of tizanidine, thus decreasing its effectiveness.
• The use of tizanidine with other muscle relaxants or neuromuscular blocking agents may result in enhanced muscle weakness and respiratory depression.
• Caution is advised when combining tizanidine with medications that prolong the QT interval, as it may further increase the risk of cardiac arrhythmias.

Following are the food interactions for Tizanidine 6mg Tablet:

• Avoid consuming grapefruit and grapefruit juice as these can increase the concentration of Tizanidine in the blood, potentially leading to increased side effects, especially drowsiness and dizziness.
• Alcohol consumption should be avoided as it can enhance the sedative effects of Tizanidine, leading to excessive drowsiness and impaired coordination.
• Consuming high-fat meals can slightly delay the absorption of Tizanidine, but it does not significantly affect its overall effectiveness.
• Avoid caffeine-containing beverages as they can reduce the relaxing effects of Tizanidine on muscles.
• Do not consume natural licorice as it can decrease the elimination of Tizanidine, leading to increased side effects.
• Avoid eating large amounts of dark chocolate as it may contain a chemical called tyramine, which can interact with Tizanidine and cause a sudden increase in blood pressure.
• Always follow the advice of your healthcare provider regarding specific dietary restrictions or recommendations while taking this medication.

Tizanidine 6mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, ensuring it remains out of reach of children and pets. Maintain a consistent room temperature, avoiding exposure to direct sunlight, excessive heat, or moisture, as these conditions can degrade the medication's quality. Always keep the tablets in their original container, tightly sealed, to prevent contamination and maintain potency. It is crucial to regularly check the expiration date on the packaging and dispose of any expired or unused tablets promptly. When disposing of the medication, do not flush it down the toilet or pour it into a drain. Instead, consult your pharmacist or local waste management guidelines for safe and environmentally friendly disposal practices to minimize any potential harm to the environment.

Following are the quick tips for Tizanidine 6mg Tablet:

• Consult your doctor before taking this medication, especially if you have liver or kidney issues.
• Take the tablet as directed by your doctor; do not crush or chew it.
• Avoid alcohol consumption while using this medication.
• Do not drive or operate machinery until you know how this medicine affects you.
• Inform your doctor about all medications you're taking to prevent potential interactions.
• Store the tablets at room temperature, away from light and moisture.
• Discontinue use and seek medical attention if you experience severe side effects.