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Folic acid and vitamin B12, also known as cobalamin, work synergistically in the body. Folic acid primarily functions as a methyl group donor, involved in various biochemical reactions. It is essential for DNA synthesis, particularly during rapid cell division, and aids in the formation of red blood cells. Vitamin B12 plays a crucial role in the metabolism of folic acid, serving as a coenzyme in the conversion of folic acid to its active form, tetrahydrofolate (THF). This active form of folic acid is necessary for the synthesis of DNA, RNA, and certain amino acids, such as methionine. Vitamin B12 also supports the normal functioning of the nervous system and the production of red blood cells in the bone marrow. Together, folic acid and vitamin B12 contribute to the maintenance of healthy blood cells, proper DNA replication, and overall cellular metabolism.

Folic Acid, Vitamin B 12

Vitamin B complex.

Tablet

The following are the uses of Folic Acid, Vitamin B 12 Tablet:

• Used for preventing and treating low blood levels of folic acid and vitamin B12.
• Used for maintaining healthy red blood cells and reducing the risk of neural tube defects during pregnancy.
• Used for supporting overall neurological health and cognitive function.
• Used for managing certain types of anemia.
• Used for promoting healthy cell growth and DNA synthesis.
• Used for boosting energy levels and reducing fatigue.
• Used for supporting cardiovascular health by regulating homocysteine levels.
• Used for enhancing mood and mental well-being.

In the case of an overdose of Folic Acid, Vitamin B12 Tablets, the primary concern is the potential for gastrointestinal symptoms. These may include nausea, stomach discomfort, and diarrhea. In more severe cases, individuals may experience allergic reactions, characterized by skin rashes, itching, or difficulty breathing. It is important to seek medical advice if an overdose is suspected, as the specific response may vary depending on the individual's health status and the amount ingested. Timely intervention can help manage any adverse effects effectively.

In the case of a missed dose of Folic Acid, Vitamin B12 Tablet, it is generally advised to take the missed dose as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare provider for guidance on how to safely resume your medication routine.

To take the Folic Acid, Vitamin B12 Tablet, place the tablet on your tongue and allow it to dissolve, or swallow it whole with a glass of water, preferably at the same time each day as directed by your healthcare professional.

Here are the conditions and situations when Folic Acid, Vitamin B12 Tablet should not be used:

• Do not take if you have a known allergy or sensitivity to folic acid, vitamin B12, or any other ingredients in the tablet.
• Avoid using this medication if you have an untreated or undiagnosed anemia.
• Not recommended for individuals with certain genetic disorders like MTHFR gene mutation, as it may affect folate metabolism.
• Should not be used in place of medical treatment for pernicious anemia, which requires vitamin B12 injections.
• Contraindicated in people with Leber's disease, a rare genetic eye condition.
• Do not take this medication if you have a history of allergic reactions to any vitamin supplements.
• Not suitable for individuals with kidney disease or those undergoing hemodialysis without consulting a doctor.
• Avoid high doses of folic acid if you have a history of seizures or epilepsy.
• Do not use this medication to treat or prevent conditions without medical supervision, especially in cases of vitamin B12 deficiency.

The side effects of Folic Acid, Vitamin B12 Tablet may include:

• Nausea and upset stomach.
• Diarrhea.
• Skin reactions, such as rashes or itching.
• Sleep disturbances, including insomnia.
• Headaches and dizziness.
• Restlessness or irritability.
• Mild allergic reactions like skin itching or rash.
• Temporary increase in blood levels of bilirubin, which can cause jaundice-like symptoms.

Following are the precautions and warnings for Folic Acid, Vitamin B12 Tablet:

• Do not exceed the recommended dosage, as high doses of folic acid may mask a Vitamin B12 deficiency, leading to potential neurological issues.
• Patients with a history of anemia or malabsorption syndromes should be monitored regularly during treatment.
• Individuals with kidney disease or those undergoing dialysis should exercise caution and consult a healthcare professional before use.
• Some individuals may experience allergic reactions to the tablet; seek medical attention if you develop symptoms like rash, itching, or difficulty breathing.
• This medication may cause temporary discoloration of urine, which is usually harmless.
• Pregnant and breastfeeding women should consult their doctor as the dosage may need adjustment during these periods.
• Keep out of reach of children. Store in a cool, dry place, away from direct sunlight.

Following are the drug interactions for Folic Acid, Vitamin B12 Tablet:

• May reduce the effectiveness of methotrexate, a drug used in cancer and autoimmune diseases, by interfering with its action.
• Can interact with antiepileptic drugs like phenytoin, phenobarbital, and primidone, possibly reducing their effectiveness.
• Folic acid supplementation might decrease the plasma levels of levetiracetam, an anticonvulsant, requiring dosage adjustments.
• May decrease the absorption of the thyroid medication levothyroxine when taken together.
• Might decrease the therapeutic effects of 5-fluorouracil, a chemotherapy drug, by inhibiting its activation.
• Vitamin B12 can interact with certain antibiotics like chloramphenicol, which can reduce the absorption of vitamin B12.
• Prolonged use of high-dose proton pump inhibitors (PPIs) might reduce vitamin B12 absorption.

Following are the food interactions for Folic Acid, Vitamin B 12 Tablet:

• Folic acid absorption may be reduced by foods high in oxalic acid (spinach, rhubarb) and phytic acid (grains, legumes). Cooking can reduce these effects.
• Vitamin B12 absorption can be hindered by excessive alcohol consumption, as it can impair the body's ability to absorb the vitamin.
• Dairy products like milk and yogurt can interfere with the absorption of vitamin B12 due to the presence of the protein, intrinsic factor.
• Chloramphenicol, an antibiotic, can decrease the blood levels of vitamin B12 by interfering with its metabolism.
• Metformin, a diabetes medication, may reduce vitamin B12 absorption, requiring monitoring and possible supplementation.
• Proton pump inhibitors (PPIs) used for acid reflux can decrease vitamin B12 absorption over time, requiring monitoring.
• Nitrous oxide, used in anesthesia, can inactivate vitamin B12, requiring supplementation for prolonged use.
• Folic acid may mask a Vitamin B12 deficiency, so ensure a balanced intake of both.

Folic Acid, Vitamin B 12 Tablets should be stored in a cool and dry place, preferably at room temperature, away from direct exposure to sunlight, heat, or moisture. It is crucial to keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain their integrity and effectiveness. Always check the expiration date on the package before using the medication, and never use it if it has expired. When disposing of any unused or expired tablets, do not flush them down the toilet or pour them into drainage systems. Instead, follow local guidelines or consult a pharmacist for safe disposal methods. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Folic Acid, Vitamin B12 Tablet:

• Take the tablet as directed by your doctor or as instructed on the label.
• Swallow the tablet whole with a glass of water, do not crush or chew.
• Take it regularly at the same time each day for best results.
• If you have difficulty swallowing, ask your pharmacist for advice on alternative formulations.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Do not take expired tablets, check the expiry date before use.
• Consult your doctor if you are pregnant, breastfeeding, or have any medical conditions.