Flixotide (50mcg) Inhaler

Fluticasone, the active ingredient in Fluticasone Inhaler, is a potent synthetic corticosteroid with a high affinity for the glucocorticoid receptor. Its primary mechanism of action is to reduce inflammation in the airways. When inhaled, fluticasone binds to glucocorticoid receptors in the airway cells, leading to the activation of anti-inflammatory genes. This process inhibits the release of inflammatory mediators such as histamine, leukotrienes, and cytokines, which are responsible for causing bronchoconstriction and airway inflammation. By suppressing the immune response and reducing inflammation, fluticasone helps to prevent and control asthma symptoms, decrease airway hyperresponsiveness, and improve lung function. The drug's localized action in the lungs also minimizes systemic side effects, making it a preferred choice for long-term management of asthma and certain chronic obstructive pulmonary diseases (COPD).

Fluticasone

Corticosteroid

Inhaler

The following are the uses of Fluticasone Inhaler:

• Used for preventing and managing asthma symptoms, such as wheezing and shortness of breath.
• Used for controlling inflammation in the airways.
• Used to provide quick relief during an asthma attack.
• Used for long-term asthma management, reducing the frequency and severity of attacks.
• Used to improve lung function and overall breathing.
• Used as a preventative measure before exposure to known triggers.
• Used for treating exercise-induced asthma.

In the case of an overdose of Fluticasone Inhaler, individuals may experience a range of symptoms. These can include an increased heart rate, nervousness, and tremors. Other possible effects are headaches, dizziness, and a feeling of nausea. If you suspect an overdose, it is important to seek medical advice promptly. A healthcare professional will be able to provide guidance and support, ensuring the best course of action is taken to address any potential health risks associated with the overdose.

In the case of a missed dose of Fluticasone Inhaler, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to restart the medication or provide specific instructions for catching up on missed doses. It is crucial to maintain a consistent dosing routine for optimal effectiveness.

To use the Fluticasone Inhaler, shake the inhaler well, exhale completely, then inhale deeply and slowly while pressing down on the inhaler to deliver the medication into your lungs, holding your breath for a few seconds before exhaling.

Here are the conditions and situations when Fluticasone Inhaler should not be used:

• Must not be used in individuals with a known allergy or hypersensitivity to Fluticasone or any of the other ingredients in the inhaler.
• Not suitable for individuals with active or untreated tuberculosis (TB).
• Should not be used in patients with untreated fungal, bacterial, or viral infections in the respiratory tract.
• Contraindicated in individuals with a recent history of heart attack or severe heart disease.
• Should be avoided in patients with untreated glaucoma or cataracts.
• Not recommended for use in individuals with liver disease or severe liver impairment.
• Must not be used to treat acute asthma attacks or status asthmaticus.
• Contraindicated in individuals with a rare genetic problem of galactose intolerance, severe lactase deficiency, or glucose-galactose malabsorption.

The side effects of Fluticasone Inhaler may include:

• Sore throat
• Headache
• Hoarseness or voice changes
• Dry mouth or throat irritation
• Cough
• Bronchitis
• Sinusitis
• Thrush (oral fungal infection)
• Increased heart rate

Following are the precautions and warnings:

• Fluticasone Inhaler should not be used by patients who are allergic to fluticasone or any of the other ingredients in the inhaler.
• It is essential to inform your doctor about any existing medical conditions, especially lung infections like tuberculosis, herpes eye infections, or liver problems.
• Patients with a history of glaucoma or cataracts should use this medication with caution as it may worsen these conditions.
• Fluticasone can weaken the immune system, so be cautious about exposure to infections and inform your doctor if you develop any symptoms of an infection.
• This medication may affect bone mineral density, so long-term use should be monitored by a healthcare professional, especially in children.
• Avoid sudden withdrawal, especially if you have been on high doses for a long time. Gradually reducing the medication is recommended.
• Patients should inform their dentist or doctor about Fluticasone use before any surgery or medical procedure.

Following are the drug interactions for Fluticasone Inhaler:

• Ketoconazole and other strong CYP3A4 inhibitors can increase the risk of systemic corticosteroid effects when used with fluticasone.
• Fluticasone may interact with other inhaled medications, such as salmeterol, requiring careful monitoring for potential adverse effects.
• Erythromycin, a CYP3A4 inhibitor, can increase fluticasone exposure, potentially leading to increased corticosteroid effects.
• Ritonavir and other protease inhibitors can increase fluticasone exposure, necessitating monitoring for systemic corticosteroid effects.
• Itraconazole, a potent CYP3A4 inhibitor, may elevate fluticasone levels, warranting caution and monitoring.
• Clarithromycin, another CYP3A4 inhibitor, can enhance fluticasone's effects, requiring adjustment of dosage if needed.
• HIV protease inhibitors, such as ritonavir, can significantly increase fluticasone concentrations, necessitating close observation.

Following are the food interactions to be aware of when using Fluticasone Inhaler:

• Fluticasone may interact with high-fat meals, leading to increased exposure of the drug in the body. It is advisable to use the inhaler 1-2 hours before or 2 hours after eating a high-fat meal.
• Grapefruit juice should be consumed with caution as it can affect the metabolism of Fluticasone, potentially increasing its levels in the blood and the risk of side effects.
• Alcohol may not directly interact with Fluticasone, but it can worsen respiratory conditions and decrease the effectiveness of the medication. It's best to limit alcohol consumption while using the inhaler.
• Dairy products, especially milk, might cause issues when taken with Fluticasone due to potential protein binding interactions, which may reduce the effectiveness of the medication.
• Avoid black tea and green tea as they contain compounds that can inhibit the metabolism of Fluticasone, leading to higher blood levels and potential side effects.
• Certain fruits like bananas, avocados, and kiwifruit are rich in tyramine, which might interact with Fluticasone, affecting blood pressure. It's best to consume these in moderation.
• Chocolate contains compounds that can interact with Fluticasone, potentially affecting its metabolism and blood levels. Limit consumption to avoid any potential interactions.
• Avoid excessive consumption of spicy foods as they can irritate the airways and potentially worsen respiratory symptoms, reducing the effectiveness of the Fluticasone Inhaler.

Fluticasone Inhaler should be stored in a cool, dry place, preferably at room temperature (around 20-25°C) and away from direct sunlight, moisture, and heat. Keep the inhaler in its original packaging until you are ready to use it, ensuring the mouthpiece remains clean and protected. Do not puncture or incinerate the canister, and avoid exposing it to high temperatures or open flames. Once the inhaler is empty or has passed its expiration date, it should be disposed of properly. To safely dispose of the inhaler, consult your pharmacist or healthcare provider for local guidelines on medication disposal, ensuring it is done in an environmentally friendly manner, and keep it out of the reach of children and pets at all times.

Following are the quick tips for Fluticasone Inhaler:

• Before using the inhaler, ensure you understand the proper technique; ask your healthcare provider for guidance if needed.
• Shake the inhaler well before each use to ensure an even distribution of the medication.
• Breathe out slowly before placing the mouthpiece in your mouth for inhalation.
• Inhale deeply and slowly to ensure the medication reaches your lungs effectively.
• Hold your breath for a few seconds after inhalation to allow maximum absorption.
• Rinse your mouth with water after using the inhaler to minimize side effects.
• Clean the inhaler mouthpiece regularly to maintain hygiene and prevent clogging.
• Store the inhaler at room temperature, away from direct sunlight and moisture.