Fluanxol Depot (40mg/2ml) 1 Ampoule Injection

Flupenthixol's mechanism of action primarily involves its interaction with the brain's dopamine receptors. It acts as a potent antagonist at D1 and D2 dopamine receptors, particularly in the mesolimbic and mesocortical pathways. By blocking these receptors, flupenthixol reduces dopamine-mediated neurotransmission, which is believed to contribute to its therapeutic effects. This dopamine receptor blockade is thought to alleviate psychotic symptoms and improve mood in patients with schizophrenia and other psychotic disorders. Additionally, flupenthixol's actions on dopamine receptors may also contribute to its sedative and anxiolytic properties.

Flupenthixol

Antipsychotic (thioxanthene)

injection

The following are the uses of Flupenthixol injection:

• Used for treating schizophrenia and other psychotic disorders, helping to manage symptoms like hallucinations and delusions.
• Used for controlling severe behavior problems, especially in patients with long-term mental health issues.
• Used for reducing anxiety and agitation in patients with dementia or Alzheimer's disease.
• Used for managing symptoms of severe depression when combined with a tri-cyclic antidepressant.
• Used for rapid tranquilization in emergency situations to calm aggressive or violent patients.
• Used for maintaining stability in patients with chronic schizophrenia, preventing relapse.
• Used for treating patients who do not respond well to oral medications.

In the case of an overdose of Flupenthixol injection, it is important to recognize the signs and act promptly. Symptoms may include severe drowsiness, confusion, agitation, muscle stiffness, and difficulty breathing. If an overdose is suspected, seek medical assistance immediately. Quick action is vital as prompt treatment can mitigate the severity of symptoms and reduce potential long-term effects. Always ensure a safe and controlled environment to prevent such incidents, especially when handling medications.

In the case of a missed dose of Flupenthixol injection, it is important to act promptly. If you remember within a few hours of the missed dose, administer the injection as soon as possible. However, if a significant amount of time has passed, it is best to skip the missed dose and continue with the next scheduled injection. Never double the dose to make up for a missed one, as this can lead to an overdose. Consult your healthcare provider if you have any concerns or if you miss multiple doses.

To administer the Flupenthixol injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and slowly inject the prescribed volume of medication, ensuring the entire dose is delivered, then gently remove the needle and apply light pressure with a sterile cotton ball if needed.

Following are the conditions when Flupenthixol injection should be avoided or used with caution:

• Must not be used in patients with a known allergy or hypersensitivity to Flupenthixol or any of its excipients.
• Not recommended for individuals with severe central nervous system (CNS) depression or coma.
• Should not be administered to patients with untreated narrow-angle glaucoma.
• Contraindicated in patients with known or suspected pheochromocytoma.
• Avoid in patients with severe liver impairment or severe kidney disease.
• Do not use in individuals with severe cardiovascular disease or recent myocardial infarction.
• Not suitable for individuals with blood disorders such as agranulocytosis or severe neutropenia.
• Should not be used in patients with a history of seizures or epilepsy.
• Must be used with caution in elderly patients with dementia, as it may increase the risk of stroke or death.
• Avoid in individuals with known gastrointestinal obstruction or severe constipation.

The side effects of Flupenthixol injection may include:

• Restlessness and agitation
• Dry mouth and excessive thirst
• Blurred vision or eye problems
• Muscle stiffness or tremors
• Sleep disturbances, including insomnia or excessive drowsiness
• Skin rashes or itching
• Constipation or diarrhea
• Dizziness or lightheadedness

Following are the precautions and warnings for Flupenthixol injection:

• Not recommended for individuals with known hypersensitivity or allergy to Flupenthixol or related compounds.
• Requires caution in patients with a history of epilepsy or seizures, as it may lower the seizure threshold.
• Should be used with caution in patients with cardiovascular disease, as it can affect heart rate and blood pressure.
• Patients with liver or kidney impairment may require dosage adjustments, and regular monitoring is necessary.
• Elderly patients may be more sensitive to the effects, and lower doses are usually recommended.
• May cause extrapyramidal symptoms, especially in the initial stages of treatment, and patients should be monitored for such reactions.
• Not recommended for use in children and adolescents under 18 years of age.

Following are the drug interactions for Flupenthixol injection:

• It should not be used concurrently with alcohol or other central nervous system depressants like opioids or benzodiazepines, as this can lead to excessive sedation and respiratory depression.
• Flupenthixol may enhance the effects of antihypertensive drugs, resulting in a more pronounced drop in blood pressure.
• When combined with lithium, the risk of neurotoxicity increases, and regular monitoring of lithium levels is advised.
• Anticonvulsant medications may have their effects reduced by Flupenthixol, potentially lowering the seizure threshold.
• The effectiveness of levodopa in treating Parkinson's disease may be diminished by Flupenthixol.
• Drugs that prolong the QT interval, such as certain antiarrhythmics or antipsychotics, should be used cautiously due to the potential for additive effects on the heart.
• The risk of arrhythmias may increase when combined with other medications known to cause electrolyte imbalances, particularly hypokalemia.

Following are the food interactions to be aware of when taking Flupenthixol injection:

• Avoid consuming alcohol during the treatment period as it may increase the risk of side effects and negatively impact your mental alertness.
• Grapefruit and related products should be avoided as they can interfere with the metabolism of the drug, potentially leading to increased levels in the body.
• Caffeine intake should be monitored as it may exacerbate nervousness and insomnia, which are potential side effects of the medication.
• Avoid high-fat meals as they may slow down the absorption of Flupenthixol, affecting its effectiveness.
• Dairy products with high-fat content might also interact with the medication's absorption, so consider reducing their consumption.
• Ensure you stay well-hydrated by drinking adequate water, especially if you are prone to dehydration or have a history of kidney issues.
• Maintain a balanced diet rich in fruits, vegetables, and whole grains to support overall health during the treatment process.
• Always consult your healthcare provider for personalized advice regarding dietary restrictions or recommendations specific to your condition.

Flupenthixol injection should be stored in a secure and controlled environment, preferably in a locked cabinet or a designated medication storage area, away from unauthorized access. The injection should be protected from light and stored at room temperature, avoiding extreme heat or cold. It is crucial to keep the injection in its original packaging, ensuring the label remains intact for easy identification. Once opened, the injection should be used promptly and not stored for later use. Any unused or expired flupenthixol injection should be disposed of properly, following local regulations and guidelines. Do not attempt to dispose of it through household waste or wastewater systems; instead, contact a pharmacist or healthcare professional for guidance on safe disposal methods. Responsible storage and disposal practices are essential to prevent misuse and protect public health.

Following are the quick tips for Flupenthixol injection:

• Administer the injection under medical supervision for accurate dosage and administration.
• Ensure the injection is given into the muscle as directed; do not inject intravenously.
• Follow the prescribed dosage and treatment duration as advised by your doctor.
• Inform your doctor about all medications you are taking to avoid potential interactions.
• Do not miss scheduled appointments for monitoring and dose adjustments.
• Store the injection as directed, away from direct sunlight and moisture.
• Dispose of used needles and syringes safely to prevent injuries and infections.
• Contact your healthcare provider immediately if you experience severe side effects or unusual symptoms.