Fluderm (50mg) 10 Capsules

Fluconazole 50mg capsules primarily work by inhibiting the enzyme lanosterol 14-alpha-demethylase, which is crucial for the synthesis of ergosterol, a major component of fungal cell membranes. This inhibition disrupts the structure and function of the fungal cell membrane, leading to impaired membrane integrity and function. Fluconazole selectively targets fungal cells because ergosterol is specific to fungi, while having minimal effect on mammalian cells that contain cholesterol instead. This selective action contributes to its antifungal activity, making it effective against a range of fungal infections.

Fluconazole 50mg

Antifungal, Azole Derivative.

Capsule

The following are the uses of Fluconazole 50mg Capsule:

• Used for treating vaginal yeast infections, offering quick relief from itching and discomfort.
• Used for managing cryptococcal meningitis, an infection of the brain and spinal cord.
• Used to combat fungal infections, particularly in patients with weak immune systems.
• Effective for treating fungal infections of the mouth, throat, and esophagus.
• Used for preventing fungal infections in high-risk patients, ensuring protection.
• Used for managing fungal infections in various body parts, including the lungs and skin.
• Provides relief from persistent fungal infections that may resist other treatments.

To be used as per doctor's instructions

In the case of an overdose of Fluconazole 50mg Capsules, several symptoms may occur. These can include hallucinations, confusion, seizures, and an irregular heartbeat. If you suspect an overdose, seek medical advice promptly. Symptoms may vary depending on the individual's health and the amount ingested. Prompt action and medical guidance are essential to ensure appropriate treatment and manage any potential complications effectively.

In the case of a missed dose of Fluconazole 50mg Capsule, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, consult your healthcare professional for advice on how to safely resume your medication and maintain its effectiveness. It is generally recommended to take the missed dose within 12 hours of the scheduled time.

To take Fluconazole 50mg Capsule, swallow the capsule whole with a full glass of water, preferably at the same time each day, following the instructions provided by your healthcare professional, who will determine the duration of treatment based on your medical condition.

Here are the conditions or situations when Fluconazole 50mg Capsule should not be taken:

• Avoid using if you have a known allergy to Fluconazole or other azole antifungal medications.
• Not recommended for individuals with a history of liver disease or impaired liver function.
• Do not take if you are pregnant or breastfeeding, as it can cause harm to the developing fetus or infant.
• Contraindicated in patients with a rare hereditary condition known as porphyria.
• Should not be used in patients with a history of QT prolongation or heart rhythm disorders.
• Avoid using if you have a severe kidney impairment or are on dialysis.
• Not suitable for individuals with a history of serious skin reactions to antifungal medications.
• Do not use if you are taking certain medications that interact with Fluconazole, such as warfarin, phenytoin, or cyclosporine.
• Fluconazole is not recommended for individuals with a compromised immune system, such as those with HIV/AIDS or undergoing cancer treatment.
• Should not be used to treat fungal infections that are not proven or suspected to be caused by susceptible fungi.

The side effects of Fluconazole 50mg Capsule may include:

• Nausea and vomiting
• Diarrhea or constipation
• Abdominal pain
• Headache
• Dizziness or feeling lightheaded
• Skin rash or itching
• Increased liver enzymes (detected in blood tests)
• Fatigue or weakness

Following are the precautions and warnings:

• Fluconazole 50mg Capsule should not be used in patients with known hypersensitivity or allergy to azole antifungal medications.
• Patients with liver disease or impairment should use Fluconazole with caution, as it is primarily metabolized in the liver. Regular monitoring of liver function is advised.
• This medication may cause QT prolongation, a heart rhythm condition. Patients with existing heart problems or those taking other medications that prolong the QT interval should be closely monitored.
• Fluconazole can interact with other drugs; caution is advised when used with warfarin, phenytoin, rifampin, and other medications. Always inform your doctor about all medications you are taking.
• Not recommended for use during pregnancy unless the potential benefits outweigh the risks. It should be used during pregnancy only if clearly needed.
• Breastfeeding women should exercise caution, as Fluconazole is excreted in breast milk and may cause adverse effects in nursing infants.
• Patients with rare hereditary problems of galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption should not take this medication.
• Store Fluconazole capsules at room temperature, away from moisture and direct light, to maintain their potency.

Following are the drug interactions for Fluconazole 50mg Capsule:

• Concurrent use with warfarin may increase the risk of bleeding, as Fluconazole can enhance the anticoagulant effects of warfarin by inhibiting its metabolism.
• Fluconazole can increase the levels of medications metabolized by the liver, such as phenytoin, cyclosporine, tacrolimus, and rifabutin, leading to an increased risk of side effects.
• Combining Fluconazole with certain antiarrhythmic drugs (e.g., quinidine, amiodarone) may increase the risk of arrhythmias.
• Fluconazole may interact with some antidepressants, especially tricyclics and SSRIs, increasing the risk of serotonin syndrome, a potentially life-threatening condition.
• Using Fluconazole with benzodiazepines (e.g., diazepam, midazolam) may enhance their sedative effects, increasing the risk of excessive drowsiness or respiratory depression.
• Fluconazole may reduce the effectiveness of oral contraceptives, so alternative contraception methods should be considered while taking it.
• Fluconazole may interact with drugs that prolong the QT interval (e.g., certain antipsychotics, antibiotics), increasing the risk of serious heart rhythm disturbances, including torsades de pointes.
• Caution should be exercised when using Fluconazole with certain antivirals (e.g., ritonavir), as it can increase Fluconazole blood concentrations and increase the risk of side effects.
• When combined with certain medications for diabetes (e.g., sulfonylureas), Fluconazole may increase the risk of hypoglycemia (low blood sugar).

Following are the food interactions to be aware of when taking Fluconazole 50mg Capsules:

• Grapefruit and grapefruit juice consumption should be avoided as they can significantly increase the concentration of Fluconazole in the blood, potentially leading to an increased risk of side effects.
• Alcohol intake is not recommended, as it can increase the chances of liver problems and may also cause dizziness or drowsiness.
• Avoid high-fat meals, as they can slow down the absorption of Fluconazole, delaying its effectiveness.
• Cranberry juice and products containing cranberry may decrease the effectiveness of Fluconazole, so it's best to avoid them.
• Caffeine intake should be monitored as it can increase the side effects of Fluconazole, including nervousness and rapid heartbeat.
• Limit the consumption of foods high in salt and potassium, as Fluconazole can cause an increase in these levels.
• Inform your doctor if you have a history of low blood sugar levels, as Fluconazole can affect glucose levels.
• Always follow the dosage instructions provided by your healthcare professional to ensure the medication's effectiveness.

Fluconazole 50mg Capsules should be stored in a cool and dry place, preferably at room temperature, ensuring it stays below 25°C (77°F). Keep the capsules in their original container, tightly sealed, to maintain their integrity and protect them from light and moisture. It is crucial to avoid storing them in the bathroom or any areas exposed to direct sunlight or excessive heat. Always check the expiration date before using the medication, and if it has expired, do not use it and dispose of it carefully. Proper disposal methods should be followed, such as returning unused or expired capsules to a pharmacy or a designated medication disposal facility to prevent environmental contamination. Keep Fluconazole 50mg Capsules out of children's reach to prevent accidental ingestion.

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Following are the quick tips for Fluconazole 50mg Capsule:

• Take the capsule with a full glass of water, swallowing it whole without crushing or chewing.
• Fluconazole can be taken with or without food, but taking it with food may reduce the risk of stomach upset.
• Complete the full course of medication as prescribed, even if you start feeling better.
• Maintain good hydration by drinking plenty of fluids while taking this medication.
• Avoid alcohol consumption during the treatment period as it may cause adverse effects.
• Store the capsules in a cool, dry place away from direct sunlight and moisture.
• Regularly monitor your liver function if you are on long-term treatment with Fluconazole.
• Inform your doctor about all medications you are taking to prevent potential drug interactions.