FLUIBRON TAB (AMBROXOL)

Ambroxol's primary mechanism of action is as a mucolytic and expectorant. It increases the production of hydrated lung surfactant, reducing the viscosity of the mucus and improving mucociliary clearance. This effect is achieved by stimulating the activity of epithelial chloride channels, leading to increased chloride and water secretion into the airway lumen, thus hydrating the mucus and making it easier to cough up. Additionally, Ambroxol has been shown to possess antioxidant properties, reducing oxidative stress in the respiratory tract and potentially contributing to its therapeutic benefits. It also exhibits anti-inflammatory effects by inhibiting the release of pro-inflammatory mediators, which may further support its role in respiratory conditions.

Ambroxol

Mucolytic expectorant.

Tablet

The following are the uses of Ambroxol Tablet:

• Used for clearing mucus from the airways, making it easier to breathe and helping with respiratory conditions like bronchitis and pneumonia.
• Used to treat chronic obstructive pulmonary disease (COPD) to reduce phlegm production and improve lung function.
• Used for suppressing coughs by thinning and loosening mucus, providing relief from persistent coughing.
• Used in the management of cystic fibrosis to help clear thick mucus from the lungs and improve breathing.
• Used to relieve sore throat and chest congestion caused by the common cold or flu.
• Used as a mucolytic agent to reduce the viscosity of mucus, allowing for better clearance of airway secretions.
• Used for its anti-inflammatory properties, reducing inflammation in the respiratory tract.
• Used to aid in the expectoration of mucus, making it easier to cough up and clear the airways.

In the case of an overdose of Ambroxol Tablets, it is important to remain calm and seek medical advice promptly. Symptoms of an overdose may include nausea, vomiting, and an increased heart rate. Do not induce vomiting unless instructed by a healthcare professional. Prompt medical attention is advised, and the individual should be closely monitored for any signs of toxicity, with appropriate supportive care provided.

In the case of a missed dose of Ambroxol Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, it's best to set reminders or inform your healthcare provider to ensure you receive the full benefits of the medication.

To take the Ambroxol Tablet, swallow the tablet whole with a full glass of water, preferably with or after a meal, following the dosage instructions provided by your healthcare professional, which may vary based on your age and medical condition.

Following are the conditions when Ambroxol Tablet should not be used:

• Avoid use in patients with a known allergy or hypersensitivity to Ambroxol or any of its excipients.
• Not suitable for individuals with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency, or glucose-galactose malabsorption.
• Contraindicated in patients with acute or chronic liver disease.
• Should not be used if you have a history of bronchospasm or bronchial asthma.
• Not recommended for patients with severe renal impairment or end-stage renal disease.
• Avoid use during pregnancy, especially in the first trimester, unless clearly necessary.
• Not suitable for infants and young children under 2 years of age.
• Should not be used if you have a history of gastrointestinal ulceration or bleeding.
• Contraindicated in patients with a history of severe cardiovascular disease.
• Avoid use if you have a history of seizures or epilepsy, as Ambroxol may lower the seizure threshold.

The side effects of Ambroxol Tablet may include:

• Nausea and vomiting.
• Diarrhea.
• Stomach pain.
• Skin rashes or itching.
• Dizziness or lightheadedness.
• Headache.
• Dry mouth.
• Increased coughing (initial phase of treatment).

Following are the precautions and warnings for Ambroxol Tablet:

• Avoid use in patients with a known hypersensitivity or allergy to Ambroxol or any other components of the tablet.
• Patients with a history of kidney or liver disease should use with caution, as these conditions may affect the metabolism and elimination of the drug.
• Ambroxol may cause drowsiness or dizziness, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• This medication should be used with caution in elderly patients as they may be more sensitive to its side effects.
• It is important to maintain adequate fluid intake while taking Ambroxol to prevent dehydration.
• If you have a history of gastrointestinal disorders, use with caution as it may exacerbate these conditions.
• Ambroxol may interact with other medications, so patients should inform their healthcare provider about all the medicines they are taking.
• Pregnant and breastfeeding women should consult their doctor before using Ambroxol, as its safety during these periods is not fully established.

Following are the drug interactions for Ambroxol Tablet:

• Ambroxol may interact with antibiotics like amoxicillin, as it can increase the absorption of amoxicillin, potentially affecting antibiotic efficacy.
• The combination with antitussives like codeine can reduce the effectiveness of Ambroxol in clearing mucus.
• Using Ambroxol with other medications that cause respiratory depression, such as opioids, may enhance this effect and lead to breathing difficulties.
• It may increase the concentration of certain antibiotics like erythromycin, potentially raising the risk of side effects.
• Ambroxol can interact with antihistamines, such as diphenhydramine, and cause increased drowsiness.
• It can affect the metabolism of certain drugs metabolized by the liver, including some antifungal medications, and may require dosage adjustments.
• Caution is advised when using Ambroxol with bronchodilators, as it may influence their effects on airway resistance.

Following are the food interactions for Ambroxol Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as they can decrease the elimination of Ambroxol, potentially leading to increased side effects.
• Alcohol intake is not recommended as it may cause excessive drowsiness, especially when combined with the sedative effects of Ambroxol.
• Avoid excessive caffeine intake as it may counteract the sedative effects of Ambroxol, making it less effective for cough suppression.
• High-fat meals may slightly decrease the absorption of Ambroxol, so it is advisable to take the medication on an empty stomach or with a light meal.
• Dairy products containing calcium may interfere with Ambroxol's absorption, so it is best to separate them by a few hours.
• Avoid consuming large amounts of chocolate, as it contains a compound that can inhibit Ambroxol's effectiveness.
• Certain fruit juices, especially those high in antioxidants, may reduce the bioavailability of Ambroxol, so it is best to take the medication with water.
• Spicy foods may irritate the throat and increase mucus production, potentially reducing the effectiveness of Ambroxol.

Ambroxol Tablets should be stored in a cool, dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Keep the tablets in their original container, tightly sealed, to maintain their integrity and protect them from moisture and light. Avoid storing in the bathroom or kitchen cabinets as heat and humidity can affect the medication. Always check the expiration date and dispose of expired or unused tablets promptly. Proper disposal methods are crucial; do not flush or pour them down the drain. Contact your pharmacist or healthcare provider for guidance on safe disposal practices. Keep the medication away from children and pets to prevent accidental consumption.

Following are the quick tips for Ambroxol Tablet:

• Take the tablet as directed by your doctor, typically 2-3 times a day.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Maintain a consistent dosing schedule to ensure effective mucus clearance.
• It can be taken with or without food, but take it with food if you experience stomach discomfort.
• Avoid consuming alcohol while taking this medication.
• Inform your doctor if you have any lung or kidney conditions before starting this medication.
• Store the tablets in a cool, dry place, away from direct sunlight.