FLUORESCEIN IMP INJ 10'S

Fluorescein is a fluorescent dye used in ophthalmic angiography. When administered intravenously, fluorescein rapidly binds to plasma proteins, and its mechanism of action involves fluorescence and selective absorption by ocular tissues. The dye circulates through the bloodstream, and when it reaches the blood vessels of the eye, it emits a bright green fluorescence upon exposure to blue light. This fluorescence allows for visualization and imaging of the retinal and choroidal vasculature. Fluorescein molecules absorb light in the blue-violet range and emit light in the yellow-green spectrum, providing contrast and enabling detailed examination of the ocular circulation and detection of vascular abnormalities.

FLUORESCEIN

Ophthalmic diagnostic aid

Injection

The following are the uses of FLUORESCEIN Injection:

• Used for angiography, a medical imaging technique to visualize blood vessels and identify cardiovascular conditions.
• Used for assessing blood flow and circulation in the eyes, aiding in the diagnosis of eye diseases.
• Used for locating and evaluating coronary artery disease, ensuring accurate placement of catheters.
• Used for identifying tumors and abnormal blood vessel formations, aiding in cancer diagnosis and treatment planning.
• Used for investigating cerebral blood flow, crucial in understanding brain function and diagnosing neurological disorders.
• Used for evaluating organ perfusion, ensuring adequate blood supply to vital organs during surgeries and critical care.

In the case of an overdose of FLUORESCEIN Injection, it is important to seek medical assistance promptly. Symptoms may include nausea, vomiting, and diarrhea, with more severe cases resulting in kidney damage and failure. Treatment involves managing these symptoms and ensuring proper hydration. Medical professionals should be informed about the overdose to initiate appropriate interventions and prevent potential complications.

In the case of a missed dose of FLUORESCEIN Injection, it is important to consult your healthcare provider for guidance. The course of action may vary depending on the specific treatment plan and timing of the missed dose. Generally, if a dose is missed, it is best to administer it as soon as possible, unless it is close to the time for the next scheduled dose. Never double the dose to make up for a missed one without medical advice, as this may lead to potential side effects.

To administer the FLUORESCEIN Injection, draw the prescribed dose into a syringe, inject it intravenously, and ensure the needle is placed securely in a vein, following the instructions provided by your healthcare professional for proper administration.

Following are the conditions when FLUORESCEIN Injection should not be used:

• Should not be administered to patients with a known allergy or hypersensitivity to fluorescein or any of its components.
• Contraindicated in patients with severe renal impairment or end-stage kidney disease.
• Not recommended for individuals with a history of severe respiratory disorders or asthma, as it may cause bronchospasm.
• Should be avoided in patients with a history of seizures or epilepsy, as it can lower the seizure threshold.
• Not suitable for newborn infants or premature babies due to potential risks associated with immature renal function.
• Should not be used in patients with a known or suspected blood vessel abnormality, such as aneurysms, as it may lead to vessel rupture.
• Contraindicated in individuals with a history of anaphylactic or anaphylactoid reactions to contrast media.
• Should be used with caution and avoided if possible in patients with diabetes, as it may interfere with blood glucose tests.

The side effects of FLUORESCEIN Injection may include:

• Nausea and vomiting
• Mild to moderate pain at the injection site
• Itching or rash
• Dizziness or lightheadedness
• Temporary discoloration of the skin, urine, or sweat (may appear pink or orange)
• Allergic reactions, including hives, itching, or difficulty breathing
• Swelling or inflammation at the injection site
• Rare cases of severe anaphylactic reactions

Following are the precautions and warnings for FLUORESCEIN Injection:

• This medication should not be used in patients with known hypersensitivity or allergy to fluorescein or any of its components.
• It is crucial to test for allergic reactions before administration; perform a skin test to rule out potential allergic responses.
• FLUORESCEIN Injection should be used with caution in patients with compromised renal function, as it is primarily excreted by the kidneys.
• Patients with severe liver disease should be monitored closely as the drug's metabolism may be affected.
• Avoid intravenous injection; only administer the drug as an intraocular injection as directed.
• Do not use if the solution is cloudy or contains any particulate matter.
• Diabetic patients should be aware that FLUORESCEIN may interfere with blood glucose tests, leading to false results.
• Always inform your healthcare provider about all the medications you are currently taking to avoid potential drug interactions.

Following are the drug interactions for FLUORESCEIN Injection:

• Fluorescein is known to interact with povidone-iodine, a common antiseptic, potentially causing false-negative results in diagnostic tests.
• Concomitant use with topical anesthetics like proparacaine or tetracaine may increase the risk of corneal toxicity.
• Avoid using other ophthalmic medications containing fluorescein to prevent excessive staining and inaccurate test results.
• Fluorescein may interfere with some diagnostic tests, including those for blood glucose, urine protein, and certain blood coagulation tests.
• It can also affect the accuracy of tests that rely on fluorescence detection, leading to false readings.
• When used with medications that increase tear production, such as pilocarpine, the clearance of fluorescein may be affected.
• There is a potential interaction with drugs that affect ocular blood flow, like anti-glaucoma medications, which may alter the distribution of fluorescein in the eye.

Following are the food interactions for FLUORESCEIN Injection:

• Avoid citrus fruits and juices, especially grapefruit, as they may interfere with the absorption of FLUORESCEIN.
• Caffeinated beverages should be limited as they can increase blood pressure and interact with the medication's effects.
• Dairy products might reduce the absorption of FLUORESCEIN, so consider spacing out dairy intake and medication.
• High-fat meals can delay the absorption of the injection, so it is advisable to avoid fatty foods before and after administration.
• Alcohol consumption is not recommended as it may enhance the risk of side effects and interfere with the diagnostic process.
• Avoid natural health products like St. John's Wort, as they can reduce the levels of FLUORESCEIN in the body.
• Ensure you stay well-hydrated before and after the injection, but avoid excessive fluid intake to maintain accurate diagnostic results.
• Always inform your healthcare provider about your regular diet to manage any potential food-related interactions effectively.

Fluorescein Injection should be stored in a controlled environment, specifically a cool and dry place, ideally at room temperature between 20-25°C (68-77°F). Protect the injection from direct sunlight, heat, and moisture, as these can degrade the medication. Ensure the vial or ampoule is sealed tightly to maintain sterility and prevent leakage. When disposing of Fluorescein Injection, do not throw it into the regular trash or pour it down the sink or toilet. Instead, follow local guidelines for the safe disposal of medical waste or consult your healthcare provider for appropriate disposal methods. It is crucial to keep this medication away from children and pets to prevent accidental exposure or ingestion.

Following are the quick tips for FLUORESCEIN Injection:

• Ensure the injection is administered by a trained healthcare professional.
• Verify the patient's identity and the medication details before injection.
• Inject the solution slowly as directed, typically into a vein or as prescribed.
• Avoid injecting into damaged or irritated skin areas.
• Rotate injection sites to minimize tissue irritation.
• Report any signs of allergic reaction immediately.
• Store the injection as directed, away from light and moisture.