FOLLITROPE INJ 75MG

Follitropin injection, a synthetic form of the follicle-stimulating hormone (FSH), works by stimulating the growth and maturation of ovarian follicles in the ovaries. Its primary mechanism of action involves binding to FSH receptors on the granulosa cells within the ovary. This binding triggers a cascade of intracellular events, leading to increased levels of cyclic adenosine monophosphate (cAMP). Elevated cAMP levels stimulate the production of enzymes and steroids, particularly estrogen, which are crucial for follicular development and ovulation. By mimicking the natural FSH, this injection supports multiple follicular growth, promoting the release of multiple eggs during ovulation.

Follitropin

Gonadotropin

Injection

The following are the uses of Follitropin Injection:

• Used for stimulating the development of multiple follicles in the ovaries, aiding in fertility treatments.
• Used for treating women with anovulation and polycystic ovary syndrome to induce ovulation.
• Used for enhancing sperm production in men with hypogonadotropic hypogonadism.
• Used for improving success rates in assisted reproductive technologies like IVF.
• Used for patients undergoing controlled ovarian stimulation for egg retrieval.
• Used for addressing hormonal imbalances related to pituitary gland disorders.
• Used for supporting fertility preservation procedures.
• Used for helping couples with certain infertility issues conceive.

In the case of an overdose of Follitropin Injection, symptoms may include abdominal pain, ovarian enlargement, and fluid retention. These symptoms can lead to severe health complications such as ovarian hyperstimulation syndrome (OHSS), which requires prompt medical intervention. Immediate medical care should be sought if an overdose is suspected, as healthcare professionals can provide the necessary treatment and monitoring to manage the adverse effects and prevent further complications.

In the case of a missed dose of Follitropin Injection, it is important to consult your healthcare provider or fertility specialist as soon as possible. They will provide guidance on how to adjust your dosing schedule and may advise you to administer the missed dose as soon as you remember, provided it is still within a certain time frame. If the missed dose is discovered too late, they might recommend skipping the missed dose and continuing with the next scheduled dose. Do not double the dose to make up for a missed one without medical advice.

To administer the Follitropin injection, clean the injection site with an alcohol wipe, insert the needle subcutaneously or intramuscularly as directed by your healthcare provider, inject the prescribed dose slowly, and then gently remove the needle while applying pressure with a sterile cotton ball if needed.

Following are the conditions/situations when Follitropin Injection should not be used:

• Should not be used in individuals with a known allergy to Follitropin or any gonadotropin medications.
• Contraindicated in women with ovarian enlargement or cysts unrelated to polycystic ovary syndrome (PCOS).
• Not suitable for individuals with untreated thyroid or adrenal disorders.
• Should not be used in patients with pituitary gland disorders, such as pituitary adenoma or hypopituitarism.
• Contraindicated in women with unexplained vaginal bleeding or endometrial hyperplasia.
• Not recommended for individuals with ovarian, breast, or other hormone-sensitive tumors or cancer.
• Should not be used in patients with severe liver or kidney disease.
• Contraindicated in women who are already pregnant or breastfeeding.
• Should not be used in individuals with epilepsy that is not well-controlled.

The side effects of Follitropin Injection may include:

• Injection site reactions such as redness, swelling, or pain
• Abdominal pain or bloating
• Nausea and vomiting
• Headaches
• Fatigue and weakness
• Mood changes, including irritability and depression
• Ovarian hyperstimulation syndrome (OHSS)
• Increased risk of multiple pregnancies

Here are the precautions and warnings for Follitropin Injection:

• This medication should be used under strict medical supervision due to its potential side effects and risks.
• Not recommended for individuals with known hypersensitivity or allergies to Follitropin or any of its excipients.
• Patients with a history of ovarian cysts, ovarian/pelvic/abdominal disorders, or ovarian/breast/uterine cancer should exercise caution and inform their doctor before use.
• Care is required in patients with conditions like polycystic ovary syndrome (PCOS), endometriosis, or thyroid/adrenal dysfunction, as dosage adjustments may be necessary.
• Those with a history of ovarian hyperstimulation syndrome (OHSS) should be closely monitored as they are at higher risk of developing this condition again.
• Elderly patients may be more susceptible to adverse effects, so caution and regular monitoring are essential.
• Pregnant and breastfeeding women should consult their doctor before using this medication as it may pose risks to the fetus or infant.

Following are the drug interactions for Follitropin Injection:

• Concomitant use with GnRH agonists or antagonists can enhance the ovarian response, requiring careful monitoring to prevent ovarian hyperstimulation syndrome.
• Hormonal contraceptives may interfere with the effectiveness of Follitropin, as they suppress endogenous gonadotropin release.
• Androgens or anabolic steroids can counteract the effects of Follitropin, leading to reduced ovarian response.
• Medications that affect pituitary function, such as dopamine agonists or glucocorticoids, may influence the response to Follitropin treatment.
• Insulin sensitivity may be altered during Follitropin therapy, potentially requiring adjustments in antidiabetic medications.
• Certain herbal supplements like St. John's Wort may impact the efficacy of Follitropin by influencing its metabolism.
• Caution is advised when using Follitropin with other drugs that affect ovarian function, as it may increase the risk of multiple pregnancies or ovarian complications.

Following are the food interactions for Follitropin Injection:

• Avoid consuming high-fat meals as they can delay the absorption of Follitropin, potentially affecting its efficacy.
• Grapefruit and grapefruit juice should be consumed cautiously as they may influence hormone levels and interact with Follitropin, leading to unpredictable hormone fluctuations.
• Alcohol intake should be minimized as it can interfere with hormone balance and potentially exacerbate side effects associated with Follitropin.
• Caffeinated beverages may impact hormone levels and should be consumed in moderation to prevent any potential interaction with the medication.
• Maintain a balanced diet rich in nutrients to support overall health during Follitropin treatment.
• Avoid excessive consumption of cruciferous vegetables like broccoli and cauliflower, as they contain compounds that can affect hormone metabolism.
• Always follow dietary recommendations provided by your healthcare professional while undergoing Follitropin therapy.
• Stay hydrated by drinking adequate water to support overall health and medication effectiveness.

Follitropin Injection should be stored in a controlled environment, preferably in a refrigerator between 2°C to 8°C (36°F to 46°F). Protect it from direct sunlight and freezing temperatures as it may affect the potency of the medication. Always keep the injection in its original packaging to maintain its sterility and integrity. When disposing of unused or expired injections, do not throw them in the regular trash or pour them down the drain. Contact your healthcare provider or pharmacist for guidance on proper disposal methods to ensure environmental safety. It is crucial to keep the medication out of the reach of children and pets to prevent accidental exposure or ingestion. Follow local regulations and guidelines for the safe handling and disposal of pharmaceutical waste.

Following are the quick tips for Follitropin Injection:

• Store the injection as directed by your pharmacist, usually in the refrigerator.
• Allow the injection to reach room temperature before administering for a more comfortable experience.
• Ensure the injection is not frozen, as it may lose its effectiveness.
• Clean the injection site with an antiseptic wipe before administration to reduce the risk of infection.
• Inject the medication under the skin as instructed by your healthcare provider.
• Dispose of used needles and syringes safely in a puncture-proof container.
• Do not reuse needles or syringes to prevent contamination and infection.