FOROSI 2MG/500MG TAB

Metformin primarily acts by inhibiting hepatic glucose production, reducing gluconeogenesis, and enhancing insulin sensitivity in peripheral tissues. It suppresses glucose output from the liver by inhibiting gluconeogenesis and glycogenolysis. Metformin also increases the uptake of glucose by muscles and adipose tissue, making them more responsive to insulin. On the other hand, Rosiglitazone, a thiazolidinedione, acts by binding to peroxisome proliferator-activated receptor-gamma (PPAR-gamma) in adipose tissue, stimulating insulin action in these cells. This activation enhances insulin sensitivity by improving glucose uptake and utilization, leading to better glycemic control. Together, these mechanisms contribute to the overall effectiveness of the combination therapy in managing type 2 diabetes by targeting both insulin resistance and excessive glucose production.

Biguanide and Thiazolidinedione.

Tablet

The following are the uses of Metformin 500mg, Roziglitazone 2mg Tablet:

• Used for treating type 2 diabetes by lowering blood sugar levels
• Used to increase insulin sensitivity in muscle and fat cells
• Used to reduce insulin resistance, allowing the body to use insulin more effectively
• Used to lower glucose production in the liver
• Used to enhance glucose uptake by cells, helping to regulate blood sugar
• Used for weight management, as it can help reduce appetite and promote weight loss
• Used to improve cardiovascular health by lowering cholesterol and triglyceride levels
• Used to support overall metabolic health and reduce the risk of diabetes-related complications

In the case of an overdose of Metformin 500mg and Rosiglitazone 2mg tablets, individuals may experience symptoms such as nausea, vomiting, dizziness, and rapid breathing. The severity of these symptoms can vary depending on the amount ingested. It is important to seek medical advice promptly and provide information on the estimated dosage taken. Treatment for overdose may involve supportive care, monitoring vital signs, and managing any complications that arise from the excessive medication intake. Timely intervention can help mitigate potential health risks associated with overdosing on these medications.

In the case of a missed dose of Metformin 500mg, take it as soon as you remember, but skip it if it's almost time for your next scheduled dose. Do not double the dose to make up for the missed one. For Roziglitazone 2mg, if you miss a dose, take it as soon as you remember, but if it's close to your next dose, skip the missed dose and resume your regular dosing schedule. It's important not to take extra medication to compensate for a missed dose, as this may lead to potential side effects. Consult your healthcare provider if you have any concerns or questions about missed doses.

To take Metformin 500mg and Roziglitazone 2mg tablets, swallow one tablet with a full glass of water, preferably during a meal or as directed by your healthcare provider, once or twice daily as prescribed.

Following are the conditions when Metformin 500mg and Rosiglitazone 2mg Tablet should not be used:

• Not suitable for individuals with a known allergy to Metformin, Rosiglitazone, or any other thiazolidinedione (TZD) medication.
• Contraindicated in patients with severe kidney disease or kidney failure.
• Should not be used in individuals with diabetic ketoacidosis.
• Not recommended for patients with a history of heart failure or heart-related problems.
• Should be avoided in individuals with severe liver disease or liver failure.
• Not suitable for patients with a history of eye problems, such as macular edema.
• Contraindicated during pregnancy and breastfeeding.
• Should not be used in children below 10 years of age.
• Discontinue use before any radiologic procedure involving intravascular administration of iodinated contrast materials.

The side effects of Metformin 500mg, Rosiglitazone 2mg Tablet may include:

• Nausea and vomiting
• Stomach pain or discomfort
• Diarrhea
• Metallic taste in the mouth
• Weight gain
• Swelling in the hands or feet
• Weakness or fatigue
• Hypoglycemia (low blood sugar) when combined with other diabetes medications

Following are the precautions and warnings for Metformin 500mg, Rosiglitazone 2mg Tablet:

• Not recommended for individuals with a known allergy to Metformin or Rosiglitazone or any other ingredients in the tablet.
• Patients with kidney or liver problems should use with caution and under medical supervision, as dosage adjustments may be necessary.
• May cause lactic acidosis, a serious condition; discontinue use and seek medical attention if symptoms such as weakness, nausea, vomiting, or unusual sleepiness occur.
• Not recommended for patients with heart-related issues, especially heart failure.
• Patients with a history of diabetic ketoacidosis should not use this medication.
• Elderly patients may be more sensitive to the side effects; regular monitoring is recommended.
• Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding before taking this medication.

Following are the drug interactions for Metformin 500mg, and Roziglitazone 2mg Tablet:

• Furosemide and other diuretics may increase the risk of lactic acidosis when used with Metformin, leading to serious health complications.
• The blood-glucose-lowering effect of insulin and sulfonylureas can be enhanced by Metformin, increasing the risk of hypoglycemia.
• The use of Roziglitazone with gemfibrozil, a lipid-lowering drug, may increase the risk of myopathy and rhabdomyolysis.
• Beta-blockers, such as metoprolol, may mask the symptoms of hypoglycemia when used with Roziglitazone.
• The risk of fluid retention and heart failure can be increased when Roziglitazone is combined with insulin or sulfonylureas.
• Corticosteroids may reduce the effectiveness of Roziglitazone in controlling blood glucose levels.
• Certain antihypertensive medications, like ACE inhibitors, may have their effects reduced when combined with Roziglitazone.

Following are the food interactions for Metformin 500mg and Roziglitazone 2mg Tablet:

• Avoid excessive alcohol consumption as it can increase the risk of lactic acidosis, a serious side effect associated with Metformin.
• Grapefruit and grapefruit juice should be consumed cautiously as they may affect the blood glucose-lowering effect of Roziglitazone, potentially requiring dosage adjustments.
• Fatty foods may affect the absorption of Roziglitazone, so it is best to take the medication as directed by your doctor, with or without food.
• Avoid high-fat meals as they can decrease the absorption of Metformin, reducing its effectiveness.
• Maintain a consistent carbohydrate intake to ensure stable blood sugar levels when taking these medications.
• Avoid or limit the consumption of foods with high sugar content to prevent spikes in blood glucose levels.
• Follow a balanced diet as recommended by your healthcare provider to manage blood sugar levels effectively.
• Discuss any dietary changes or concerns with your doctor or dietitian to ensure proper management while taking these medications.

Metformin 500mg and Roziglitazone 2mg tablets should be stored in a cool, dry place, preferably at room temperature, ensuring protection from light and moisture. The original container should be tightly sealed to maintain the integrity of the medication. It is crucial not to expose the tablets to extreme temperatures, so avoid storage in hot or humid environments. Proper disposal of unused or expired medication is essential; do not dispose of them in sinks, toilets, or drains. Contact your local pharmacist or healthcare provider for guidance on safe disposal practices. Keep the medication securely stored away from children to prevent accidental consumption.

Following are the quick tips for Metformin 500mg, Roziglitazone 2mg Tablet:

• Always take the medication as directed by your doctor; do not alter the dosage.
• Swallow the tablets whole with a full glass of water; do not crush or chew.
• Maintain a consistent medication schedule to ensure effectiveness.
• Continue taking the medication even if you feel well; do not stop without consulting your doctor.
• Inform your doctor about all other medications you are taking to avoid interactions.
• Regularly monitor your blood sugar levels as instructed by your healthcare provider.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.