FOROSI 4MG/500MG TAB

Metformin, at a dosage of 500mg, primarily acts by reducing glucose production in the liver. It inhibits gluconeogenesis and increases insulin sensitivity in peripheral tissues, such as skeletal muscle and adipose tissue, thereby enhancing glucose uptake and utilization. On the other hand, Rosiglitazone, at 4mg, is a thiazolidinedione (TZD) class drug that selectively activates the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) in adipose tissue. This activation enhances insulin sensitivity by regulating the transcription of insulin-responsive genes involved in glucose and lipid metabolism, ultimately improving cellular uptake of glucose.

Biguanide and Thiazolidinedione.

Tablet

The following are the uses of Metformin 500mg, Roziglitazone 4mg Tablet:

• Used for treating Type 2 Diabetes
• Used to lower blood sugar levels
• Used to improve insulin sensitivity
• Used for managing insulin resistance
• Used to enhance glucose uptake by cells
• Used to regulate glucose metabolism
• Used as a long-term treatment for stable blood sugar control
• Used to support overall diabetes management when combined with a healthy lifestyle

In the case of an overdose of Metformin 500mg and Roziglitazone 4mg tablets, individuals may experience a range of symptoms. These can include nausea, vomiting, diarrhea, and abdominal pain. In more severe cases, lactic acidosis may occur, leading to rapid breathing, weakness, and decreased blood pressure. It is essential to seek medical advice promptly if an overdose is suspected, as early intervention can help manage symptoms and prevent potential complications.

In the case of a missed dose of Metformin 500mg, it is generally recommended to take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose. If it is near the time of your next dose, skip the missed dose and continue with your regular dosing schedule. For Roziglitazone 4mg, if a dose is missed, take it as soon as you remember, but if it's close to the time for your next dose, skip the missed dose and continue with your regular dosing. It is important to maintain a consistent medication routine, but if you miss a dose, consult your healthcare provider for specific guidance on how to handle missed doses.

To take Metformin 500mg and Roziglitazone 4mg tablets, swallow one tablet each with a full glass of water, preferably during or after a meal, exactly as prescribed by your healthcare provider, typically twice a day, or as directed on the prescription label.

Following are the conditions or situations when Metformin 500mg and Rosiglitazone 4mg Tablet should not be taken:

• Avoid if you are allergic to any of the components in the tablet, including Metformin or Rosiglitazone.
• Not suitable for patients with a history of diabetic ketoacidosis.
• Should not be used in individuals with severe kidney or liver disease.
• Contraindicated in patients with heart failure or severe heart problems.
• Not recommended for individuals with a history of stroke or transient ischemic attack (TIA).
• Avoid if you have a history of eye problems, such as macular edema or diabetic retinopathy.
• Should not be taken if you are on dialysis treatment.
• Not suitable for individuals with a recent history of heart attack.
• Avoid alcohol consumption while taking this medication.
• Do not take if you have a severe infection or are experiencing a traumatic event, as it may increase the risk of lactic acidosis.

The side effects of Metformin 500mg and Roziglitazone 4mg Tablet may include:

• Nausea and vomiting
• Diarrhea or constipation
• Stomach pain or discomfort
• Metallic taste in the mouth
• Weight gain
• Dizziness or lightheadedness
• Increased risk of respiratory infections
• Swelling of the hands or feet

Following are the precautions and warnings for Metformin 500mg, Rosiglitazone 4mg Tablet:

• This medication should not be initiated in patients with severe renal impairment or kidney disease, and it should be temporarily discontinued if the patient is experiencing a renal-impairing condition.
• Lactic acidosis, a rare but serious complication, is a risk; monitor for symptoms and discontinue if suspected.
• Not recommended for patients with a history of heart failure or at risk of heart failure; close monitoring is necessary.
• Regularly monitor liver function as this medication can cause liver-related side effects.
• May cause fluid retention, leading to or worsening edema; monitor and manage accordingly.
• Use with caution in patients with anemia, as it may exacerbate the condition.
• Patients with a history of heart disease, vitamin B12 deficiency, or heavy alcohol consumption should be closely monitored while on this treatment.
• Not recommended for individuals with diabetic ketoacidosis, and it should be discontinued if ketoacidosis is suspected.

Following are the drug interactions for Metformin 500mg, Roziglitazone 4mg Tablet:

• Alcohol intake may increase the risk of lactic acidosis with metformin. Avoid excessive alcohol consumption.
• Metformin can interact with contrast media used in certain medical imaging procedures, potentially leading to kidney damage. Inform your doctor if you are scheduled for any imaging tests.
• Roziglitazone may enhance the effects of insulin and other antidiabetic medications, increasing the risk of hypoglycemia. Regular blood sugar monitoring is advised.
• The effect of Roziglitazone may be reduced by corticosteroids, making blood sugar control more challenging.
• Drugs that affect liver enzymes, such as rifampicin, can alter the metabolism of Roziglitazone.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) might decrease the effectiveness of Roziglitazone in controlling blood sugar.
• Certain medications like diuretics, beta-blockers, and ACE inhibitors may interact with Metformin and Roziglitazone, affecting kidney function and blood pressure.

Following are the food interactions for Metformin 500mg and Roziglitazone 4mg Tablet:

• Alcohol intake should be limited as it can increase the risk of lactic acidosis, a rare but serious side effect associated with Metformin.
• Avoid excessive consumption of fatty foods as Roziglitazone can increase the risk of fluid retention and heart-related issues.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Roziglitazone, leading to increased drug levels in the body.
• Maintain a balanced diet and monitor blood sugar levels regularly, as Metformin can sometimes cause low blood sugar.
• Avoid high-sugar foods and beverages to prevent blood sugar spikes.
• Stay hydrated, especially when taking Metformin, to reduce the risk of kidney-related side effects.
• Consult a healthcare professional for personalized dietary advice, especially if you have specific dietary restrictions or preferences.
• Follow a healthy meal plan to maximize the effectiveness of these medications in managing blood sugar levels.

Metformin 500mg and Roziglitazone 4mg tablets should be stored in a cool, dry place, preferably at room temperature (around 25°C) in their original, tightly sealed container. Protect the tablets from excessive heat, moisture, and direct sunlight, as these conditions can degrade the medication. Always check the expiration date on the packaging, and do not use the medication if it is past its expiry. When disposing of unused or expired tablets, do not throw them in the trash or flush them down the toilet. Instead, follow local guidelines for pharmaceutical waste disposal or consult your pharmacist for safe disposal options. It is crucial to keep these medications out of the reach of children and pets to prevent accidental consumption.

Following are the quick tips for Metformin 500mg, Rosiglitazone 4mg Tablet:

• Always take the medication as directed by your doctor, typically with meals.
• Swallow the tablets whole without crushing or chewing for proper absorption.
• Maintain a consistent medication schedule to ensure stable blood sugar levels.
• Inform your doctor about all medications you're taking to prevent interactions.
• Regularly monitor your blood sugar levels as advised by your healthcare provider.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.
• Do not share your medication with others, even if they have similar symptoms.