FORSTEO 20/80 MCG MICROLITERS SOL 3ML

Teriparatide, the active ingredient in Teriparatide Liquid, is a synthetic analog of the human parathyroid hormone (PTH). Its mechanism of action primarily involves stimulating specific receptors on the surface of osteoblasts, which are cells responsible for bone formation. When Teriparatide binds to these receptors, it activates intracellular signaling pathways that lead to increased osteoblast activity and bone formation. This results in the stimulation of new bone formation, enhanced bone mineralization, and improved bone microarchitecture. Teriparatide's mechanism of action is distinct from other osteoporosis treatments as it directly promotes bone growth rather than solely inhibiting bone resorption, making it an effective therapeutic option for certain patients with osteoporosis.

Teriparatide, Parathyroid Hormone.

Solution

The following are the uses of Teripratide Liquid:

• Used for treating osteoporosis in postmenopausal women and men at increased risk of fracture.
• Used to promote bone formation and increase bone density, reducing the risk of fractures.
• Used in the management of chronic pain associated with bone injuries or certain bone-related conditions.
• Used to enhance bone healing and regeneration in cases of fractures or bone defects.
• Used to improve mobility and reduce the risk of falls in elderly patients with bone-related issues.
• Used as an alternative to traditional osteoporosis treatments when other therapies are not suitable or effective.

In the case of an overdose of Teriparatide Liquid, it is important to remain calm and take immediate action. Contact a healthcare professional or a poison control center for guidance. They will provide specific instructions based on the amount ingested and the patient's medical history. The primary concern with an overdose is an increased risk of side effects, which may include nausea, dizziness, and bone pain. Prompt medical assessment is essential to manage any potential complications effectively.

In the case of a missed dose of Teriparatide Liquid, it is important to take the prescribed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a medication tracker to help you stay on track with your treatment plan. Consult your healthcare provider if you have any concerns or questions regarding missed doses.

To administer Teripratide Liquid, use the provided syringe to draw the prescribed dose from the vial, inject it subcutaneously into the thigh or abdomen, and gently press the plunger to ensure the entire dose is delivered.

Following are the conditions/situations when Teriparatide Liquid should not be used:

• Should not be used in individuals with a known allergy to Teriparatide or any of its ingredients.
• Contraindicated in patients with a history of bone cancer or any condition that raises the risk of bone cancer.
• Not recommended for individuals with hypercalcemia (high blood calcium levels).
• Should not be used in patients with severe kidney disease or uncontrolled kidney failure.
• Contraindicated during pregnancy or breastfeeding.
• Not suitable for individuals with a history of skeletal or metabolic bone diseases.
• Should not be used in children and adolescents who are still growing.
• Contraindicated in patients with a recent or healing fracture in the thigh bone.
• Avoid use if the patient has had radiation therapy or surgery involving the skeleton.

The side effects of Teripratide Liquid may include:

• Dizziness
• Nausea and vomiting
• Headache
• Diarrhea
• Fatigue or weakness
• Joint pain and muscle stiffness
• High blood pressure
• Skin reactions such as rash or itching.

Following are the precautions and warnings for Teripratide Liquid:

• Teripratide should not be used in patients with a history of hypersensitivity or allergy to any of its components, including teriparatide acetate.
• It is intended for subcutaneous injection only and should not be administered intravenously or intramuscularly.
• Caution is advised in patients with a history of bone disorders, hypercalcemia, or metabolic bone diseases, as monitoring of serum calcium levels may be necessary.
• Patients with a history of kidney stones or hypercalciuria should be monitored for recurrence during treatment.
• Teripratide may cause dizziness or vertigo; patients should be cautious when driving or operating machinery until they know how the medication affects them.
• Not recommended for use in children and adolescents under 18 years of age due to insufficient data on safety and efficacy.
• Teripratide should be used with caution in elderly patients, as they may be more susceptible to its side effects.

Following are the drug interactions for Teripratide Liquid:

• Concurrent use with angiotensin-converting enzyme (ACE) inhibitors may increase the risk of hypotension, especially in volume-depleted patients.
• NSAIDs (nonsteroidal anti-inflammatory drugs) can reduce the effectiveness of Teripratide, as they may counteract its bone-forming properties.
• Thiazide diuretics might lead to increased calcium excretion, which could potentially reduce the bone-building effects of Teripratide.
• Calcium supplements or antacids containing calcium should be taken at least 1 hour apart from Teripratide to avoid interference with absorption.
• Bisphosphonates, a class of drugs used to treat osteoporosis, may have additive effects with Teripratide, but their combination requires careful monitoring due to potential side effects.
• Concomitant use with other parathyroid hormone-related drugs is not recommended, as it may lead to excessive bone resorption and hypercalcemia.
• Teripratide may increase the risk of bleeding when used with anticoagulants, requiring close monitoring of coagulation parameters.
• Drugs affecting the renal system, such as certain antibiotics and diuretics, could potentially influence Teripratide's clearance and efficacy.

Following are the food interactions for Teripratide Liquid:

• Avoid consuming high-sodium foods like processed snacks, canned soups, and fast food as Teriparatide can increase the risk of high blood pressure.
• Limit caffeine intake from coffee, tea, and energy drinks as it may interfere with the medication's bone-building effects.
• Alcohol should be consumed in moderation, as excessive alcohol can impair bone health and potentially interact with the medication's effects.
• Maintain a balanced diet rich in calcium and vitamin D to support the medication's bone-strengthening benefits. Include dairy, leafy greens, and fortified foods.
• Avoid grapefruit and grapefruit juice as they may alter the medication's absorption and increase the risk of side effects.
• Stay hydrated by drinking adequate water to support overall health and kidney function while on Teriparatide treatment.
• Follow a healthy, varied diet, and consider consulting a dietitian for personalized advice to optimize the benefits of Teriparatide.

Teripratide Liquid should be stored in a cool and dry environment, preferably at room temperature between 15-30°C (59-86°F). Protect it from direct sunlight, heat, and freezing temperatures to maintain its stability. Keep the medication in its original packaging, ensuring the container is tightly sealed to prevent contamination. It is crucial not to use the liquid if it changes color or becomes cloudy. When disposing of unused or expired Teripratide Liquid, do not flush it down the toilet or pour it down the drain. Instead, follow local guidelines or consult a pharmacist for safe disposal methods to protect the environment. Always keep medications out of the sight and reach of children to prevent accidental consumption.

Following are the quick tips for Teripratide Liquid:

• Store the liquid in the refrigerator at 2-8°C (36-46°F) and protect it from freezing.
• Do not shake the container vigorously; gentle mixing is recommended.
• Use a sterile syringe to withdraw the prescribed dose, ensuring accuracy.
• Discard any unused portion after opening; do not reuse or save for later use.
• Always use the medication as directed by your healthcare professional.
• Report any side effects or changes in health status to your doctor promptly.
• Regularly monitor your health and follow-up with medical appointments as advised.