Fortum (250mg) 1 Vial Injection

Ceftazidime is a beta-lactam antibiotic that exerts its bactericidal effect by interfering with bacterial cell wall synthesis. It specifically binds to and inhibits essential enzymes called penicillin-binding proteins (PBPs) that are responsible for cross-linking peptidoglycan strands in the bacterial cell wall. By inhibiting PBPs, ceftazidime disrupts the formation of a strong and stable cell wall, leading to cell lysis and bacterial death. This mechanism of action is highly effective against a wide range of Gram-negative bacteria, including Pseudomonas aeruginosa, which is known for its resistance to many other antibiotics.

Ceftazidime 250mg

Cephalosporin antibiotic.

Injection

The following are the uses of Ceftazidime 250mg injection:

• Used for treating severe bacterial infections like pneumonia, skin and soft tissue infections, and complicated urinary tract infections.
• Used for surgical patients to prevent infections.
• Used for patients with weakened immune systems or those undergoing chemotherapy.
• Used for bone and joint infections caused by bacteria.
• Used for intra-abdominal infections and gynecological infections.
• Used for bloodstream infections (sepsis) and meningitis.
• Used for patients with cystic fibrosis to manage respiratory infections.

To be administered as per instruction of a healthcare practitioner

In the case of an overdose of Ceftazidime 250mg injection, prompt medical attention is necessary. Overdose symptoms may include nausea, vomiting, diarrhea, and seizures. Seek emergency medical care if you suspect an overdose, as immediate treatment can help prevent potential complications. The healthcare provider will likely monitor vital signs and may administer supportive measures to manage the overdose's effects. Quick action is vital to ensure the best possible outcome.

In the case of a missed dose of Ceftazidime 250mg injection, it is important to administer the missed dose as soon as possible. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one. If you have missed multiple doses, contact your healthcare provider for guidance, as they may need to adjust your dosing regimen. It is essential to maintain a consistent medication routine for the best therapeutic outcome.

To administer Ceftazidime 250mg injection, gently swirl the vial to dissolve the powder completely, then withdraw the medication into a syringe and inject it slowly into the muscle or intravenous fluid as directed by your healthcare professional, ensuring the entire dose is delivered.

Here are the conditions or situations when Ceftazidime 250mg injection should not be used:

• Avoid if you have a known allergy to Ceftazidime or any other beta-lactam antibiotics.
• Do not use if you have a history of severe allergic reactions to any type of antibiotics.
• Contraindicated in individuals with a history of severe kidney disease or significantly impaired kidney function.
• Should not be used if you have a known sensitivity to any of the excipients in the injection formulation.
• Not recommended for individuals with a history of seizures or conditions that increase the risk of seizures.
• Avoid using if you have a history of severe gastrointestinal diseases, especially colitis.
• Do not administer if you have a history of severe blood disorders or low white blood cell counts.

The side effects of Ceftazidime 250mg Injection may include:

• Nausea and vomiting
• Diarrhea
• Skin rashes or itching
• Headache
• Dizziness
• Injection site reactions (redness, swelling, or pain)
• Allergic reactions (hives, difficulty breathing, swelling of the face/lips/tongue)
• Changes in liver function tests

Following are the precautions and warnings for Ceftazidime 250mg injection:

• This medication is intended for intravenous or intramuscular use only, and should not be administered orally or through any other route.
• Patients with a history of allergic reactions to penicillin or other beta-lactam antibiotics should inform their healthcare provider before using Ceftazidime, as cross-sensitivity may occur.
• Prolonged use may lead to the overgrowth of non-susceptible organisms, including fungi. Regularly monitor patients for secondary infections.
• Renal function should be monitored during prolonged treatment, especially in patients with pre-existing renal impairment.
• Elderly patients may be more susceptible to adverse reactions; dosage adjustments might be necessary.
• Safety and efficacy in neonates and infants below 2 months of age have not been established.
• Ceftazidime should be used with caution in patients with a history of gastrointestinal diseases, particularly colitis, as it may exacerbate these conditions.
• Discontinue use if signs of anaphylactic reactions or severe cutaneous adverse reactions occur.

Following are the drug interactions for Ceftazidime 250mg injection:

• Aminoglycosides (e.g., gentamicin) and nephrotoxic drugs may increase the risk of kidney damage when used with ceftazidime.
• Probenecid can increase the concentration of ceftazidime by reducing its excretion, potentially enhancing its effects.
• Ceftazidime may reduce the effectiveness of oral contraceptives, requiring alternative birth control methods.
• The risk of bleeding may increase when combined with anticoagulants like warfarin.
• Using ceftazidime with other antibiotics like vancomycin or aminoglycosides can lead to an increased risk of ototoxicity.
• Nephrotoxic agents like furosemide or other diuretics may exacerbate kidney-related side effects.
• Concurrent use with neuromuscular blocking agents may prolong the effects of these agents, requiring close monitoring.

Following are the food interactions for Ceftazidime 250mg Injection:

• Avoid consuming alcohol during the treatment period as it may increase the risk of side effects and affect the effectiveness of the medication.
• Grapefruit and grapefruit juice should be consumed with caution as they may alter the absorption and metabolism of Ceftazidime, potentially leading to increased drug levels in the body.
• High-fat meals can affect the absorption of Ceftazidime, so it is advisable to maintain a consistent diet and avoid significant changes in fat intake during the course of treatment.
• Avoid caffeinated beverages as they may enhance the potential for side effects, particularly in terms of nervous system stimulation.
• Dairy products, especially milk, can potentially decrease the absorption of Ceftazidime. Consider separating milk consumption from medication intake by a few hours.
• Vitamin and mineral supplements, particularly those containing calcium, iron, or zinc, can interact with Ceftazidime. It is best to maintain a consistent supplementation routine and consult a healthcare professional for guidance.
• Avoid consuming large amounts of sugary foods or drinks as they may impact the overall effectiveness of the medication.
• Maintain a balanced diet and stay well-hydrated to support overall health and aid in the recovery process.

Ceftazidime 250mg injection should be stored in a controlled environment, preferably at room temperature between 20-25°C (68-77°F), away from excessive heat, direct sunlight, and moisture. Protect the injection vials from freezing temperatures as they may affect the medication's potency. Always keep the medication in its original packaging, ensuring the vial's integrity is intact. Once opened, unused portions should be discarded properly, never reused, or shared. It is crucial to dispose of any expired or unused injections through a medicine take-back program or by following local guidelines for pharmaceutical waste disposal, ensuring it does not contaminate the environment. Keep this medication out of the reach of children and pets to prevent accidental exposure.

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Following are the quick tips for Ceftazidime 2.5g Injection:

• Administer the injection as directed by your healthcare professional, ensuring the prescribed dosage and frequency.
• Only trained medical personnel should perform the injection procedure.
• Ensure the injection site is clean and disinfected before administration.
• Inject the medication slowly into the vein over the recommended time frame.
• If using an infusion, ensure the solution is fully dissolved and appears clear before administration.
• Do not mix Ceftazidime with other medications unless instructed by your doctor.
• Monitor for any signs of allergic reaction during and after the injection.
• Store the injection as directed on the packaging, away from direct sunlight and moisture.