Fosomin (250mg/ml) 60ml Suspension

Fosfomycin 250mg Syrup/Suspension primarily works by inhibiting the initial stage of bacterial cell wall synthesis. It specifically targets the enzyme enoyl-acyl carrier protein reductase (ENR), which is crucial for the production of fatty acids and the formation of the cell wall. By binding to and blocking the action of ENR, fosfomycin disrupts the synthesis of peptidoglycan, a major component of the bacterial cell wall. This disruption leads to the weakening and eventual rupture of the cell wall, resulting in bacterial cell death. This mechanism of action makes fosfomycin effective against a range of Gram-positive and Gram-negative bacteria, as it targets a fundamental process required for bacterial survival and growth.

Fosfomycin 250mg

Antibiotic

Suspension

The following are the uses of Fosfomycin 250mg Syrup/Suspension:

• Used for treating uncomplicated lower urinary tract infections caused by susceptible bacteria.
• Used for targeting specific types of bacteria, particularly E. coli, that cause UTIs.
• Used for its unique mechanism of action, disrupting bacterial cell wall synthesis.
• Used for its ability to reach high concentrations in the urine, providing targeted treatment.
• Used for children and adults, offering a convenient dosing option for those who cannot swallow tablets.
• Used for short-term treatment, typically lasting 3-7 days, to effectively eliminate the infection.
• Used for reducing symptoms such as painful urination, urgency, and frequency associated with UTIs.

In the case of an overdose of Fosfomycin 250mg Syrup/Suspension, the severity of symptoms can vary. Common effects may include gastrointestinal issues like nausea, vomiting, and diarrhea. More serious cases could lead to electrolyte imbalances, affecting the heart and nervous system. Immediate medical intervention is necessary to manage symptoms, provide supportive care, and prevent potential complications. Prompt treatment can help mitigate the risks associated with overdosing on this medication.

In the case of a missed dose of Fosfomycin 250mg Syrup/Suspension, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed with your treatment.

To take Fosfomycin 250mg Syrup/Suspension, measure the prescribed dose using a measuring cup or oral syringe, shake the bottle well before each use, and administer the medication by mouth, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Following are the conditions/situations when Fosfomycin 250mg Syrup/Suspension should not be used:

• Do not use in patients with a known allergy or hypersensitivity to fosfomycin or other ingredients in the medication.
• Not suitable for individuals with severe renal impairment or kidney failure.
• Should not be used to treat viral infections such as the common cold or flu.
• Contraindicated in patients with a history of gastrointestinal diseases or conditions that significantly affect the digestive system.
• Not recommended for children under 5 years of age due to potential adverse effects on bone and tooth development.
• Avoid using if you have a history of gastrointestinal disorders such as inflammatory bowel disease or severe constipation.

The side effects of Fosfomycin 250mg Syrup/Suspension may include:

• Diarrhea
• Nausea and vomiting
• Abdominal pain or discomfort
• Headache
• Dizziness
• Skin rashes or itching
• Vaginal itching or discharge
• Yeast infections

Following are the precautions and warnings for Fosfomycin 250mg Syrup/Suspension:

• Do not use if you are allergic to fosfomycin or any other ingredients in the syrup.
• Fosfomycin should be used with caution in patients with kidney disease, as it may require dose adjustments.
• Avoid alcohol consumption while taking this medication, as it may increase the risk of side effects.
• Do not drive or operate heavy machinery if you experience dizziness or drowsiness as a side effect.
• Not recommended for children below 12 years of age without medical supervision.
• Pregnant and breastfeeding women should consult their doctor before taking this medication, as it may pose risks to the fetus or infant.
• Ensure you complete the full course of treatment, even if symptoms improve, to prevent the development of antibiotic resistance.
• Store the medication at room temperature, away from moisture and light, and keep it out of reach of children.

Following are the drug interactions for Fosfomycin 250mg Syrup/Suspension:

• Probenecid can decrease the elimination of fosfomycin, leading to increased levels of the antibiotic in the body.
• Fosfomycin may reduce the absorption of cyclosporine, potentially decreasing its effectiveness.
• Concomitant use with antacids containing aluminum, magnesium, or calcium can decrease the absorption of fosfomycin, reducing its efficacy.
• It may decrease the effectiveness of hormonal contraceptives, including birth control pills, patches, or rings.
• Warfarin interaction can increase the risk of bleeding, and monitoring of INR is recommended.
• When combined with methotrexate, it can increase methotrexate levels, potentially leading to toxicity.
• Fosfomycin may reduce the absorption of levothyroxine, requiring dosage adjustments.

Following are the food interactions for Fosfomycin 250mg Syrup/Suspension:

• Avoid consuming dairy products like milk, cheese, or yogurt within 2 hours before and after taking Fosfomycin as calcium in dairy can bind to the medication and reduce its absorption.
• Avoid high-fiber foods like whole grains, nuts, and seeds, as they may decrease the absorption of Fosfomycin.
• Stay away from iron-rich foods such as red meat, liver, and iron-fortified cereals as iron can interfere with the antibiotic's effectiveness.
• Limit your consumption of acidic foods like citrus fruits and juices, as they can potentially reduce the efficacy of Fosfomycin.
• Alcohol consumption should be avoided as it may increase the risk of side effects and may also reduce the effectiveness of the medication.
• There is no known interaction with caffeine, but it's best to moderate caffeine intake to avoid potential stomach irritation.
• Always take Fosfomycin as directed by your healthcare provider, and ensure you complete the full course of treatment.

Fosfomycin 250mg Syrup/Suspension should be stored at room temperature, between 68°F and 77°F (20°C and 25°C), in a dry and dark place, away from direct sunlight and moisture. Ensure the medication is tightly sealed in its original container to maintain its integrity and prevent contamination. Do not expose it to freezing temperatures or excessive heat, as this can damage the medication. Always check the expiration date, and dispose of any unused or expired syrup responsibly; do not pour it down the drain or flush it, but consult a pharmacist for guidance on proper disposal. Keep the medication away from children to prevent accidental consumption.

Following are the quick tips for Fosfomycin 250mg Syrup/Suspension:

• Ensure you complete the full course of medication as prescribed, even if symptoms improve.
• Administer the syrup with a measuring cup or oral syringe for accurate dosing.
• Store the syrup in a cool, dry place, away from direct sunlight and moisture.
• Avoid freezing the medication; keep it at room temperature.
• Do not mix the syrup with other medications unless advised by your doctor.
• Dispose of any unused or expired medication safely and responsibly.
• Consult your healthcare provider if you have any concerns or experience persistent side effects.