Fragmin (10000IU/10ml) 1 Pre-Filled Syringe Injection

Dalteparin, a low-molecular-weight heparin, exerts its effect by inhibiting coagulation factors. It primarily targets factor Xa, disrupting the conversion of prothrombin to thrombin. This action interferes with the common pathway of coagulation, thereby inhibiting both intrinsic and extrinsic clotting cascades. Dalteparin's mechanism involves binding to antithrombin III, which enhances its inhibitory effect on factor Xa, ultimately preventing the formation of fibrin clots. This targeted inhibition of factor Xa plays a crucial role in managing thromboembolic disorders by effectively reducing the risk of blood clot formation without directly affecting platelet aggregation.

Low molecular weight heparin

Syringe

The following are the uses of Dalteparin Syringe:

• Used for preventing deep vein thrombosis (DVT) and blood clots in patients undergoing abdominal surgery, hip replacement, or medical conditions that increase the risk of blood clots.
• Used for treating existing blood clots in the lungs (pulmonary embolism) and in the veins (deep vein thrombosis).
• Used for preventing blood clots in cancer patients who are at high risk.
• Used for maintaining the patency of central venous catheters, reducing the risk of blood clots forming around the catheter.
• Used for treating blood clots during pregnancy, a condition known as venous thromboembolism (VTE).
• Used for reducing the progression of coronary artery disease in patients with unstable angina or non-Q-wave myocardial infarction.
• Used for preventing blood clots in patients with heparin-induced thrombocytopenia (HIT), a rare reaction to heparin.

In the case of an overdose of Dalteparin Syringe, the severity of symptoms can vary. Common signs may include excessive bleeding, such as nosebleeds, bleeding gums, or easy bruising. More severe cases can lead to internal bleeding, which may manifest as blood in vomit, stools, or urine. If an overdose is suspected, prompt medical intervention is necessary. Treatment involves closely monitoring vital signs and providing supportive care to manage bleeding complications.

In the case of a missed dose of Dalteparin Syringe, it is important to administer the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of bleeding. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication. It is crucial to maintain a consistent dosing schedule for the best therapeutic effect.

To administer Dalteparin Syringe, twist the pre-filled syringe's cap to break the seal, then slowly press the plunger to inject the prescribed dose subcutaneously, rotating injection sites as directed by your healthcare professional.

Here are the conditions and situations when Dalteparin Syringe should not be used:

• Do not use if you have a known allergy or hypersensitivity to Dalteparin or other low molecular weight heparins.
• Contraindicated in individuals with active or recent severe bleeding, such as gastrointestinal bleeding or bleeding in the brain.
• Should not be used in patients with a low platelet count (thrombocytopenia) or conditions that increase the risk of bleeding, such as certain blood disorders.
• Not recommended for individuals with severe kidney disease or uncontrolled high blood pressure.
• Avoid using if you have a history of heparin-induced thrombocytopenia (HIT) or heparin-induced skin reactions.
• Do not use if you have an active peptic ulcer or other bleeding lesions in the digestive tract.
• Contraindicated during pregnancy, especially in the first trimester, unless the potential benefits outweigh the risks.
• Not suitable for individuals with severe liver disease or active liver bleeding.

The side effects of Dalteparin Syringe may include:

• Bleeding at injection site
• Easy bruising
• Nosebleeds
• Blood in urine or stool
• Unusual or prolonged bleeding (such as from cuts, gums)
• Vomiting blood or coffee-ground-like material
• Coughing up blood
• Severe stomach pain or pain behind the breastbone
• Headache or dizziness
• Hair loss

Following are the precautions and warnings for Dalteparin Syringe:

• Do not use if you are allergic to Dalteparin or any other similar anticoagulant medications.
• This medication should be used with caution in patients with a history of bleeding disorders, as it may increase the risk of bleeding.
• Regular monitoring of blood clotting parameters is necessary during treatment.
• Not recommended for patients with active major bleeding or uncontrolled high blood pressure.
• Patients with kidney problems should be closely monitored as the dosage may need to be adjusted.
• Elderly patients may be more susceptible to bleeding risks, so caution is advised.
• Always inform your doctor about all the medications you are taking to avoid potential drug interactions.

Following are the drug interactions for Dalteparin Syringe:

• Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of bleeding when used with Dalteparin.
• Platelet aggregation inhibitors like clopidogrel and ticagrelor can further enhance the risk of bleeding.
• Thrombolytic agents such as alteplase and streptokinase may lead to excessive anticoagulation.
• Warfarin and other oral anticoagulants require careful monitoring due to potential additive effects on coagulation.
• The effect of Dalteparin may be reduced by heparin neutralizers like protamine sulfate.
• Drugs affecting hemostasis, including thrombin inhibitors and factor Xa inhibitors, can increase bleeding risk.
• Caution is advised when using Dalterparin with antiplatelet agents like prasugrel, as it may potentiate their effects.

Following are the food interactions for Dalteparin Syringe:

• Grapefruit consumption should be limited as it may interact with Dalteparin, affecting blood clotting and potentially increasing the risk of bleeding.
• Avoid alcohol as it can increase the risk of bleeding when combined with Dalteparin, especially with long-term use.
• High-sodium foods should be consumed in moderation as Dalteparin can increase sodium levels in the body, particularly in patients with kidney issues.
• Foods with high levels of vitamin K, like leafy greens, should be monitored as they can impact blood clotting and may require dosage adjustments.
• Avoid cranberry juice as it may interfere with the effectiveness of Dalteparin, potentially reducing its anticoagulant properties.
• Maintain a balanced diet, as Dalteparin may affect blood sugar levels, and consult a dietician for personalized advice.
• There are no direct food interactions that affect Dalteparin's absorption, but individual responses may vary, so consult your healthcare provider.

Dalteparin Syringe should be stored properly to maintain its effectiveness and safety. Keep the syringe in a cool, dry location, preferably at room temperature, ensuring it is protected from direct sunlight and moisture. It's crucial to store the medication in its original packaging, tightly sealed, to prevent contamination. Avoid placing it in areas like the bathroom or near heat-emitting appliances, as temperature fluctuations can impact the drug's stability. Always adhere to the expiration date, and when disposing of any unused or expired medication, do not flush or pour it down the drain. Consult a pharmacist or healthcare professional for appropriate disposal methods, and keep the medication out of children's reach to prevent accidental ingestion.

Following are the quick tips for Dalteparin Syringe:

• Consult your doctor or pharmacist for specific instructions on how to inject this medication properly.
• Ensure you understand the technique and follow the instructions provided.
• Clean the injection site with an alcohol wipe before administering the injection.
• Rotate injection sites to minimize bruising and irritation.
• Do not inject into areas where the skin is tender, bruised, or has scars.
• Do not reuse syringes or needles; dispose of them properly in a sharps container.
• Inform your doctor if you have any bleeding problems or upcoming surgeries.